Coupled multiphysics and chemistry simulations of PCR microreactors with active control

2001 International Conference on Modeling and Simulation of Microsystems - MSM 2001

Volumn , Issue , 2001, Pages 574-577

  Athavale, M M ^a   Chen, Z J ^a   Furmanczyk, M ^a   Przekwas, A J ^a  

^a CFD RESEARCH CORPORATION   (United States)

Author keywords

DNA amplification; Multiphysics Numerical methods; PCR microreactors; PCR thermal control

Indexed keywords

AMPLIFICATION; COMPUTATIONAL FLUID DYNAMICS; COMPUTER SIMULATION; COMPUTER SOFTWARE; CONTROL EQUIPMENT; DNA; HEAT TRANSFER; MATHEMATICAL MODELS; MICROELECTROMECHANICAL DEVICES; NUMERICAL METHODS; STRUCTURAL DESIGN;

DNA AMPLIFICATION; MULTIPHYSICS NUMERICAL METHODS; PCR MICROREACTORS; PCR THERMAL CONTROL;

QUANTUM THEORY;

EID: 6344289597     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (6)

1. CFD-ACE+ Users' Manual, CED Research Corp., 2000.
2. MAST Reference Manual, Release 5.0, Analogy Inc., Beaverton, OR, 1999.
3. Hunicke-Smith, S.P., "PCR and Cycle Sequencng Reactions: A New Device and Engineering Model," Ph.D. Thesis, Stanford University, May 1997.
4. Yu, H. et.al., "A Miniaturized and Integrated Plastic Thermal Chemical Reactor for Genetic Analysis," Micro Total Analysis System (μ-TAS) 2000, pp.545-548.
5. Kopp, M.U., de Mello, A.J., and Manz, A., "Chemical Amplification: Continuous-flow PCR on a Chip," Science, vol. 280, pp. 1046, 1998.
6. Przekwas, A.J., Makhijani, V.B., Athavale, M.M., Klein, A. and Bartsch, P., "Computational Simulation of Bio-Microfluidic Processes in Integrated DNA Biochips," Micro Total Analysis System 2000, pp.561-564.