Enhancing transdermal drug transport with low-frequency ultrasound

Drug Discovery Today

Volumn 9, Issue 21, 2004, Pages 913-

  Ng, Ka Yun ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Drug Discovery; Mannitol; Non thermal mechanisms; Peptides; Pharmaceutical Science; Stratum corneum; Techniques Methods; Thermal mechanisms

Indexed keywords

PEPTIDE DERIVATIVE; POLYNUCLEOTIDE;

DRUG DELIVERY SYSTEM; DRUG TRANSPORT; ENERGY TRANSFER; ENZYME DEGRADATION; FREQUENCY MODULATION; HUMAN; MOLECULAR WEIGHT; SHORT SURVEY; SKIN PERMEABILITY; SUSTAINED DRUG RELEASE; TEMPERATURE DEPENDENCE; ULTRASOUND;

EID: 6344280605     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(04)03233-7     Document Type: Note

References (8)

1. Scheuplein R.J., Blank I.H. Permeability of the skin. Physiol. Rev. 51:1971;702-747
2. Prausnitz M.R., et al. Current status and future potential of transdermal drug delivery. Nat. Rev. Drug Discov. 3:2004;115-124
3. Lavon I., Kost J. Ultrasound and transdermal drug delivery. Drug Discov. Today. 9:2004;670-676
4. Barnett S.B., et al. The sensitivity of biological tissue to ultrasound. Ultrasound Med. Biol. 23:1977;805-812
5. Nyborg W.L. Biological effects of ultrasound: development of safety guidelines. Part II: general review. Ultrasound Med. Biol. 27:2001;301-333
6. Mitragotri S., et al. A mechanistic study of ultrasonically enhanced transdermal drug delivery. J. Pharm. Sci. 84:1995;697-706
7. Tezel A., et al. A theoretical analysis of low-frequency sonophoresis: dependence of transdermal transport pathways on frequency and energy density. Pharm. Res. 19:2002;1841-1846
8. Merino G., et al. Frequency and thermal effects on the enhancement of transdermal transport by sonophoresis. J. Control Release. 88:2003;85-94