Is sleep apnea a risk factor for stroke? A critical analysis

Minerva Medica

Volumn 95, Issue 4, 2004, Pages 291-305

  Mohsenin, V ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

Apnea; Cerebarvascular accidents; Cerebrovascular circulation; Hypertension; Sleep

Indexed keywords

CAUSE OF DEATH; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DISABILITY; DISEASE ASSOCIATION; DYSLIPIDEMIA; HEART DISEASE; HEMODYNAMICS; HUMAN; HYPERTENSION; MORBIDITY; MORTALITY; OBESITY; PATHOGENESIS; PREVALENCE; REVIEW; RISK FACTOR; SLEEP APNEA SYNDROME; SMOKING; STROKE; UNITED STATES;

ARRHYTHMIA; ARTERIOSCLEROSIS; BIOLOGICAL MARKERS; BLOOD COAGULATION; CEREBROVASCULAR ACCIDENT; HEART SEPTAL DEFECTS, ATRIAL; HUMANS; RISK FACTORS; SLEEP APNEA, OBSTRUCTIVE; SNORING;

EID: 6344280150     PISSN: 00264806     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (84)

1. Special Report from National Institute of Neurological Diseases and Stroke. Classification of cerebrovascular disease III. Stroke 1990;21:637-76.
2. Sacco R. Risk factors and outcomes for ischemic stroke. Neurology 1995;45 Suppl:S10-4.
3. American Heart Association. 2002 Heart and Stroke Statistical Update. Dallas, Texas: American Heart Association 2002.
4. Bronner L, Kanter D, Manson J. Primary prevention of stroke. N Engl J Med 1995;333:1392-400.
5. Broderick J, Brott T, Kothari R, Miller R, Khoury J, Pancioli A et al. The Greater Cincinnati/Northern Kentucky Stroke Study: preliminary first-ever and total incidence rates of stroke among blacks. Stroke 1998;29:415-21.
6. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993;328:1230-5.
7. Mohsenin V. Sleep-related breathing disorders and risk of stroke. Stroke 2001;32:1271-8.
8. He J, Kryger M, Zorick F, Conway W, Roth T. Mortality and apnea index in obstructive sleep apnea. Experience in 385 male patients. Chest 1988;94:9-14.
9. Marti S, Sampol G, Munoz X, Torres F, Roca A, Lloberes P et al. Mortality in severe sleep apnoea/hypopnoea syndrome patients: impact of treatment. Eur Respir J 2002;20:1511-8.
10. Young T, Peppard P, Gottlieb D. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 2002;165:1217-39.
11. Mokdad A, Ford E, Bowman B, Dietz WH, Vinicor F, Bales VS et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 2003;289:76-9.
12. Must A, Spadano J, Coakley E, Field A, Colditz G, Dietz W. The disease burden associated with overweight and obesity. JAMA 1999;282:1523-9.
13. Telakivi T, Partinen M, Koskenvuo M, Salmi T, Kaprio J. Periodic breathing and hypoxia in snorers and controls: validation of snoring history and association with blood pressure and obesity. Acta Neurol Scand 1987;76:69-75.
14. Partinen M, Palomaki H. Snoring and cerebral infarction. Lancet 1985;2:1325-6.
15. Koskenvuo M, Kaprio J, Telakivi T, Partinen M, Heikkila K, Sarna S. Snoring as a risk factor for ischaemic heart disease and stroke in men. Br Med J (Clin Res Ed) 1987;294:16-9.
16. Spriggs D, French J, Murdy J, Curless R, Bates D, James O. Snoring increases the risk of stroke and adversely affects prognosis. Q J Med 1992;83:555-62.
17. Palomaki H. Snoring and the risk of ischemic brain infarction. Stroke 1991;22:1021-5.
18. Smirne S, Palazzi S, Zucconi M, Chierchia S, Ferini-Strambi L. Habitual snoring as a risk factor for acute vascular disease. Eur Respir J 1993;6:1357-61.
19. Jennum P, Schultz-Larsen K, Davidsen M, Christensen N. Snoring and risk of stroke and ischaemic heart disease in a 70 year old population. A 6-year follow-up study. Int J Epidemiol 1994;23:1159-64.
20. Neau J, Meurice J, Paquereau J, Chavagnat J, Ingrand P, Gil R. Habitual snoring as a risk factor for brain infarction. Acta Neurol Scand 1995;92:63-8.
21. Hu F, Willet W, Manson J, Colditz GA, Rimm EB, Speizer FE et al. Snoring and the risk of cardiovascular disease in women. J Am Coll Cardiol 2000;35:308-13.
22. Waller P, Bhopal R. Is snoring a cause of vascular disease? An epidemiological review. Lancet 1989;1:143-6.
23. Partinen M, Guilleminault C. Daytime sleepiness and vascular morbidity at seven-year follow-up in obstructive sleep apnea patients. Chest 1990;97:27-32.
24. Mohsenin V, Valor R. Sleep apnea in patients with hemispheric stroke. Arch Phys Med Rehabil 1995;76:71-6.
25. Good D, Henkle J, Gelber D, Welsh J, Verhulst S. Sleep-disordered breathing and poor functional outcome after stroke. Stroke 1996;27:252-9.
26. Dyken M, Somers V, Yamada T, Ren Z, Zimmerman M. Investigating the relationship between stroke and obstructive sleep apnea. Stroke 1996;27:401-7.
27. Bassetti C, Aldrich M. Sleep apnea in acute cerebrovascular diseases: final report on 128 patients. Sleep 1999;22:217-23.
28. Parra O, Arboix A, Bechich S, Garcia-Eroles L, Montserrat JM, Lopez JA et al. Time course of sleep-related breathing disorders in first-ever stroke or transient ischemic attack. Am J Respir Crit Care Med 2000;161:375-80.
29. Shahar E, Whitney C, Redline S, Lee ET, Newman AB, Nieto FJ et al. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med 2001;163:19-25.
30. Whisnant J, Busford J, Bernstein E, Cooper E, Dyken M, Eastone D. National Institute of Neurologic Diseases and Stroke special report: classification of cerebrovascular disease. Stroke 1990;21:637-76.
31. Sandberg O, Franklin KA, Bucht G, Gustafson Y. Sleep apnea, delirium, depressed mood, cognition, and ADL ability after stroke. J Am Geriatr Soc 2001;49:391-7.
32. Iranzo A, Santamaria J, Berenguer J, Sanchez M, Chamorro A. Prevalence and clinical importance of sleep apnea in the first night after cerebral infarction. Neurology 2002;58:911-6.
33. Kaneko Y, Hajek V, Zivanovic V, Raboud J, Bradley T. Relationship of sleep apnea to functional capacity and length of hospitalization following stroke. Sleep 2003;26:293-7.
34. Cherkassky T, Oksenberg A, Froom P, Ring H. Sleep-related breathing disorders and rehabilitation outcome of stroke patients: a prospective study. Am J Phys Med Rehabil 2003;82:452-5.
35. D'Ambrosio C, Bowman T, Mohsenin V. Quality of life in patients with obstructive sleep apnea. Effect of nasal continuous positive airway pressure: a prospective study. Chest 1999;115:123-9.
36. Kaneko Y, Floras J, Usui K, Plante J, Tkacova R, Kubo T et al. Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea. N Engl J Med 2003;348:1233-41.
37. Pepperell J, Ramdassingh-Dow S, Crosthwaite N, Mullins R, Jenkinson C, Stradling JR et al. Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised parallel trial. Lancet 2002;359:204-10.
38. Findley L, Smith C, Hooper J, Dineen M, Suratt P. Treatment with nasal CPAP decreases automobile accidents in patients with sleep apnea. Am J Respir Crit Care Med 2000;161:857-9.
39. Sandberg O, Franklin KA, Bucht G, Eriksson S, Gustafson Y. Nasal continuous positive airway pressure in stroke patients with sleep, apnoea: a randomized treatment study. Eur Respir J 2001;18:630-4.
40. Wessendorf T, Wang Y, Thilmann A, Sorgenfrei U, Konietzko N, Teschler H. Treatment of obstructive sleep apnoea with nasal continuous positive airway pressure in stroke. Eur Respir J 2001;18:623-9.
41. Balfors E, Franklin K. Impairment in cerebral perfusion during obstructive sleep apneas. Am J Respir Crit Care Med 1994;150:1587-91.
42. Leung R, Bradley T. Sleep apnea and cardiovascular disease. Am J Respir Crit Care Med 2001;164:2147-65.
43. Nieto F, Young T, Lind B, Shahar E, Samet JM, Redline S et al. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community based study. JAMA 2000;283:1829-36.
44. Peppard P, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 2000;342:1378-84.
45. Somers V, Dyken M, Clary M, Abboud F. Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 1995;96:1897-904.
46. Becker H, Jerrentrup A, Ploch T, Grote L, Penzel T, Sullivan CE et al. Effect of nasal continuous positive airway pressure treatment on blood pressure in patients with obstructive sleep apnea. Circulation 2003;107:68-73.
47. Klingelhofer J, Hajak G, Matzander G, Schulz-Varszegi M, Sander D, Ruther E et al. Dynamics of cerebral blood flow velocities during normal human sleep. Clin Neurol Neurosurg 1995;97:142-8.
48. Madsen P, Schmidt J, Holm S, Vorstrup S, Lassen N, Wilschiodtz G. Cerebral oxygen metabolism and cerebral blood flow in man during light sleep (stage 2). Brain Res 1991;557:217-20.
49. Diomedi M, Placidi F, Cupini L, Bernardi G, Silvestrini M. Cerebral hemodynamic changes in sleep apnea syndrome and effect of continuous positive airway pressure treatment. Neurology 1998;51:1051-6.
50. Droste D, Berger W, Schuler E, Krauss J. Middle cerebral artery blood flow velocity in healthy persons during wakefulness and sleep: a transcranial Doppler study. Sleep 1993;16:603-9.
51. Fischer A, Chaudry B, Taormina M, Akhtar B. Intracranial hemodynamics in sleep apnea. Chest 1992;102:1402-6.
52. Hoshi Y, Mizukami S, Tamura M. Dynamic features of hemodynamic and metabolic changes in human brain during all-night sleep as revealed by near-infrared spectroscopy. Brain Res 1994;652:257-62.
53. Lenzi P, Zoccoli G, Walker A, Franzini C. Cerebral blood flow regulation in REM sleep: a model for flow metabolism coupling. Arch Ital Biol 1999;137:165-79.
54. Sakai F, Meyer J, Karacan I, Derman S, Yamamoto M. Normal human sleep: regional cerebral hemodynamics. Ann Neurol 1980:471-8.
55. Shiomi T, Guilleminault C, Stoohs R, Schnittger I. Leftward shift of the intraventricular septum and pulsus paradoxus in obstructive sleep apnea syndrome. Chest 1991;100:894-902.
56. Siebler M, Nachtmann A. Cerebral hemodynamics in obstructive sleep apnea. Chest 1993;103:1118-9.
57. Netzer N, Werner P, Jochums I, Lehmann M, Strohl K. Blood flow of the middle cerebral artery with sleep-disordered breathing: correlation with obstructive hypopneas. Stroke 1998;29:87-93.
58. Franklin K. Cerebral haemodynamics in obstructive sleep apnoea and Cheyne-Stokes respiration. Sleep Med Rev 2002;6:429-41.
59. Zwillich C, Devlin T, White D, Douglas N, Weil J, Martin R. Bradycardia during sleep apnea. Characteristics and mechanism. J Clin Invest 1982;69:1286-92.
60. Fichter J, Bauer D, Arampatzis S, Fries R, Heisel A, Sybrecht G. Sleep-related breathing disorders are associated with ventricular arrhythmias in patients with an implantable cardioverter defibrillator. Chest 2002;122:558-61.
61. Javaheri S, Parker T, Liming J, Corbett BS, Nishiyama H, Wexler L et al. Sleep apnea in 81 ambulatory male patients with stable heart failure: types and their prevalences, consequences, and presentations. Circulation 1998;97:2154-9.
62. Kanagala R, Murali N, Friedman P, Ammash NM, Gersh BJ, Ballman KV et al. Obstructive sleep apnea and the recurrence of atrial fibrillation. Circulation 2003;107:2589-94.
63. Lechat P, Mas J, Lascault G, Loron P, Theard M, Klimczac M et al. Prevalence of patent foramen ovale in patients with stroke. N Engl J Med 1988;318:1148-52.
64. Shanoudy H, Soliman A, Raggi P, Liu J, Russell D, Jarmukli N. Prevalence of patent foramen ovale and its contribution to hypoxemia in patients with obstructive sleep apnea. Chest 1998;113:91-6.
65. Beelke M, Angeli S, Del Sette M, De Carli F, Canovaro P, Nobili L et al. Obstructive sleep apnea can be provocative for right-to-left shunting through a patent foramen ovale. Sleep 2002;25:856-62.
66. Wilhelmsen L, Svardsudd K, Kristoffer K, Larsson B, Wellin L, Tiblin G. Fibrinogen as a risk factor stroke and myocardial infarction. N Engl J Med 1984;311:501-5.
67. Resch K, Ernst E, Matrai A, Paulsen H. Fibrinogen and viscosity as risk factors for subsequent cardiovascular events in stroke survivors. Ann Intern Med 1992:117:371-5.
68. Toss H, Lindhaul B, Siegbahn A, Wallentin L. Prognostic influence of increased fibrinogen and C-reactive protein levels in unstable coronary artery disease. Frisc Study Group. Fragmin during instability in coronary artery disease. Circulation 1997;96:4204-10.
69. Eber B, Schumacher M. Fibrinogen: its role in the hemostatic in atherosclerosis. Semin Thromb Hemost 1993;19:104-7.
70. Chin K, Ohi M, Kita H, Noguchi T, Otsuka N, Tsuboi T et al. Effects of NCPAP therapy on fibrinogen levels in obstructive sleep apnea syndrome. Am J Respir Crit Care Med 1996;153:1972-6.
71. Wessendorf T, Thilmann A, Wang Y, Schreiber A, Konietzko N, Teschler H. Fibrinogen levels and obstructive sleep apnea in ischemic stroke. Am J Respir Crit Care Med 2000;162:2039-42.
72. Elwood P, Renaud S, Sharp D, Beswick A, O'Brien J, Yarnell J. Ischemic heart disease and platelet aggregation. The Caerphilly Collaborative Heart Disease Study. Circulation 1991;83:38-44.
73. Thaulow E, Erikssen J, Sandvik L. Blood platelet count and function are related to total and cardiovascular death in apparently healthy men. Circulation 1991;84:613-7.
74. Toffler G, Brezinski D, Shafer A, Czeisler CA, Rutherford JD, Willich SN et al. Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death. N Engl J Med 1987;316:1514-8.
75. Bokinsky G, Miller M, Ault K, Husband P, Mitchell M. Spontaneous platelet activation and aggregation during obstructive sleep apnea and its response to therapy with nasal continuous positive airway pressure: a preliminary investigation. Chest 1995;108:625-30.
76. Dimsdale J, Coy T, Ziegler M, Ancoli-Israel S, Clausen J. The effect of sleep apnea on plasma and urinary catecholamines. Sleep 1995;18:377-81.
77. Fletcher E, Miller J, Schaaf J. Urinary catecholamines before and after tracheostomy in patients with obstructive sleep apnea and hypertension. Sleep 1987;10:35-44.
78. Wedzicha J, Syndercombe-Court D, Tan K. Increased platelet aggregate formation in patients with chronic airflow obstruction and hypoxemia. Thorax 1991;46:504-7.
79. Newman A, Nieto J, Guidry U, Lind BK, Redline S, Shahar E et al. Relation of sleep-disordered breathing to cardiovascular disease risk factors. AmJ Epidemiol 2001;154:50-9.
80. Young, Peppard P, Palta M, Hla KM, Finn L, Morgan B et al. Population-based study of sleep-disordered breathing as a risk factor for hypertension. Arch Intern Med 1997;157:1746-52.
81. Lavie L. Obstructive sleep apnoea syndrome: an oxidative stress disorder. Sleep Med Rev 2003;7:35-51.
82. Naughton M, Benard D, Liu P, Rutherford R, Rankin F, Bradley T. Effects of nasal CPAP on sympathetic activity in patients with heart failure and central sleep apnea. AmJ Respir Crit Care Med 1995;152:473-9.
83. Yokoe T, Minoguchi K, Matsuo H, Oda N, Minoguchi H, Yoshino G et al. Elevated levels of C-reactive protein and interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway pressure. Circulation 2003;107:1129-34.
84. Turkington P, Bamford J, Wanklyn P, Elliott M. Prevalence and predictors of upper airway obstruction in the first 24 hours after acute stroke. Stroke 2002;33:2037-42.