Pharmacokinetics of articaine hydrochloride in tumescent local anesthesia for liposuction

Journal of Clinical Pharmacology

Volumn 44, Issue 11, 2004, Pages 1282-1289

  Grossmann, Matthias ^a   Sattler, Gerhard ^b   Pistner, Hans ^c   Oertel, Reinhard ^d   Richter, Klaus ^d   Schinzel, Stefan ^e   Jacobs, Laurent Didier ^e  

^a Inst fur Klin Pharmakol Bobenheim   (Germany)

^b Rosenparkklinik   (Germany)

^c HELIOS KLINIKUM ERFURT   (Germany)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^e SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

Articaine; Liposuction; Local anesthetics; Pharmacokinetics; Tumescent anesthesia

Indexed keywords

ANTIBIOTIC AGENT; ANTICOAGULANT AGENT; ARTICAINE; ARTICAINIC ACID; DRUG METABOLITE; HEPARIN; LOCAL ANESTHETIC AGENT; PARACETAMOL; REMIFENTANIL;

ABDOMEN; ADULT; ANESTHESIOLOGICAL TECHNIQUES; ARTICLE; BLOOD SAMPLING; CANNULA; CHIN; CLINICAL ARTICLE; CLINICAL TRIAL; DEEP VEIN THROMBOSIS; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG METABOLISM; DRUG SAFETY; FEMALE; FEVER; HEADACHE; HEMATOMA; HIP; HUMAN; LIPOSUCTION; LIQUID CHROMATOGRAPHY; LOCAL ANESTHESIA; MALE; MASS SPECTROMETRY; MULTICENTER STUDY; OPEN STUDY; PATIENT SATISFACTION; PHASE 2 CLINICAL TRIAL; POSTOPERATIVE COMPLICATION; POSTOPERATIVE INFECTION; POSTOPERATIVE PAIN; SIDE EFFECT; SURGICAL PATIENT; TREATMENT OUTCOME; VISUAL ANALOG SCALE;

ADULT; ANESTHETICS, LOCAL; CARTICAINE; FEMALE; HUMANS; LIPECTOMY; MALE; MIDDLE AGED;

EID: 6344278051     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/0091270004269014     Document Type: Article

References (18)

1. Sommer B, Sattler G. Tumeszenz-Lokalanästhesie Weiterentwicklung der Lokalanästhesieverfahren für die operative Dermatologie. Hautarzt. 1990;49:351-360.
2. Beck-Schimmer B, Pasch T. Tumescent technique for local anesthesia. Anasthesiol Intensivmed Notfallmed Schmerzther. Feb 2002; 37:84-88.
3. Sattler G, Rapprich S, Hagedorm M. Tumeszenz-Lokalanästhesie- Untersuchung zur Pharmakokinetik von Prilocain. Zeitschrift für Hautkrankheiten. 1997;72:522-525.
4. Sagoo KS, Inoue K, Winker W, Salfeld K. Pharmakokinetische Untersuchungen bei der Tumeszenz-Lokalanästhesie mit Prilocain in der Varizenchirurgie. Phlebologie. 2000;29:154-162.
5. Klein JA. Tumescent technique for regional anesthesia permits lidocaine doses of 35 mg/kg for liposuction. J Dermatol Surg Oncol. Mar 1990;16:248-263.
6. Klein JA. Tumescent technique for local anesthesia improves safety in large-volume liposuction. Plast Reconstr Surg. 1993;92:1085-1098; discussion 1099-1100.
7. Klein JA. The tumescent technique: anesthesia and modified liposuction technique. Dermatol Clin. 1990;8:425-437.
8. Coleman WP III, Glogau RG, Klein JA, et al. American Academy of Dermatology Guidelines/Outcomes Committee: guidelines of care for liposuction. J Am Acad Dermatol. 2001;45:438-447.
9. Grazer FM, de Jong RH. Fatal outcomes from liposuction: census survey of cosmetic surgeons. Plast Reconstr Surg. 2000;105:436-446.
10. Hanke CW, Bernstein G, Bullok S. Safety of tumescent liposuction in 15,336 patients: national survey results. Dermatol Surg. 1995;21:459-462.
11. Oertel R, Rahn R, Kirch W. Clinical pharmacokinetics of articaine. Clin Pharmacokinet. 1997;33:417-425.
12. Oertel R, Berndt A, Kirch W. Saturable in vitro metabolism of articaine by serum esterases: does it contribute to the persistence of the local anesthetic effect? Reg Anesth. 1996;21:576-581.
13. Kirch W, Kitteringham N, Lambers G, Hajdu P, Ohnhaus EE. Die klinische Pharmakokinetik von Articain nach intraoraler und intramuskulärer Applikation. Schweiz Monatsschr Zahnheilkd. 1983;93:714-719.
14. Malamed SF, Gagnon S, Leblanc D. Articaine hydrochloride: a study of the safety of a new amide local anesthetic. J Am Dent Assoc. 2001;132:177-185.
15. Malamed SF, Gagnon S, Leblanc D. Efficacy of articaine: a new amide local anesthetic. J Am Dent Assoc. 2000;131:635-642.
16. Hagerty T, Klein P. Fat partitioning of lidocaine in tumescent liposuction. Ann Plast Surg. 1999;42:372-375.
17. Hardy SP, Ortiz-Colberg R, Poquette MA. Re: fat partitioning of lidocaine in tumescent liposuction. Ann Plast Surg. 1999;43:574.
18. Simon MA, Vree TB, Gielen MJ, Booij LH. Comparison of the disposition kinetics of lidocaine and (+/-)prilocaine in 20 patients undergoing intravenous regional anaesthesia during day case surgery. J Clin Pharm Ther. Apr 1997;22:141-146.