Saturable in vitro metabolism of articaine by serum esterases does it contribute to the persistence of the local anesthetic effect?

Regional Anesthesia

Volumn 21, Issue 6 SUPPL., 1996, Pages 576-581

  Oertel, R ^a   Berndt, A ^a   Kirch, W ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Articaine; Dentistry; Local anesthetics; Metabolism; Michaelis menten kinetics

Indexed keywords

ARTICAINE; ARTICAINIC ACID; ESTERASE;

ARTICLE; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; DRUG ELIMINATION; ENZYME METABOLISM; LOCAL ANESTHESIA; MATHEMATICAL ANALYSIS; MICHAELIS CONSTANT; PH MEASUREMENT; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TOOTH EXTRACTION;

ANESTHETICS, LOCAL; CARTICAINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESTERASES; HUMANS; HYDROGEN-ION CONCENTRATION;

EID: 0029819635     PISSN: 0146521X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Tucker GT, Mather LE. Clinical pharmacokinetics of local anaesthetics. Clin Pharmacokinet 1979: 4: 241-278.
2. Estler CJ. Lokalanästhetika. Eigenschaften, Wirkungsweise, Pharmakokinetik. Med Monatsschr Pharm 1986: 9: 197-210.
3. Kirch W, Kitteringham N, Lambers G, Hajdu P, Ohnhaus EE. Die klinische Pharmakokinetik von Articain nach intraoraler und intramuscukulärer Applikation. Schweiz Monatsschr Zahnmed 1983: 93: 714-719.
4. Müller WP, Weiser P, Scholler KL. Pharmacokinetics of articaine in mandibular nerve block. Reg Anesth 1991: 14: 52-55.
5. Oertel R, Richter K, Weile K, Gramatté T, Berndt A, Feller K. A simple method for the determination of articaine and its metabolite articaine acid in dentistry: Application to a comparison of articaine and lidocaine concentrations in alveolus blood. Methods Find Exp Clin Pharmacol 1993: 15: 541-547.
6. Vree TB, Baars AM, van Oss GE, Booij LH. High-performance liquid chromatography and preliminary pharmacokinetics of articaine and its 2-carboxy metabolite in human serum and urine. J Chromatogr 1988: 424: 440-444.