Quantification of DEK-CAN fusion transcript by real-time reverse transcription polymerase reaction in patients with t(6;9) acute myeloid leukemia

Haematologica

Volumn 89, Issue 10, 2004, Pages 1267-1269

  Tobal, Khalid ^a   Frost, Lindsay ^a   Yin, John A Liu ^a  

^a MANCHESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ARTICLE; CASE REPORT; CHROMOSOME TRANSLOCATION; DEK CAN GENE; DIAGNOSTIC ACCURACY; FEMALE; GENE; GENE FUSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LEUKEMIA REMISSION; MINIMAL RESIDUAL DISEASE; REAL TIME POLYMERASE CHAIN REACTION; REAL TIME REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RELAPSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY;

ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE MARROW TRANSPLANTATION; CHROMOSOMES, HUMAN, PAIR 6; CHROMOSOMES, HUMAN, PAIR 9; COMPUTER SYSTEMS; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; LEUKEMIA, MYELOCYTIC, ACUTE; MIDDLE AGED; ONCOGENE PROTEINS, FUSION; POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; SALVAGE THERAPY; TRANSLOCATION, GENETIC; TRANSPLANTATION, AUTOLOGOUS;

EID: 6344262434     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Cuneo A, Kerim S, Vandenberghe E, Van Orshoven A, Rodhain J, Bosly A, et al. Translocation t(6;9) occuring in acute myelofibrosis, myelodysplastic syndrome, and acute nonlymphocytic leukemia suggests multipotent stem cell involvement. Cancer Genet Cytogenet 1989;42:209-19.
2. Soekarman D, von Lindern M, Daenen S, de Jong B, Fonatsch C, Heinze B, et al.The translocation (6;9)(p23;q34) shows consistent rearrangement of two genes and defines a myeloproliferative disorder with specific clinical features. Blood 1992;79:2990-7.
3. Von Lindern M, Poustka A, Lerach H, Grosveld G. The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9p34. Mol Cell Biol 1990;10:4016-26.
4. Nakano H, Shimamotio Y, Suga K, Kobayashi M. Detection of minimal residual disease in a patient with acute myeloid leukemia and t(6;9) at the time of peripheral blood stem cell transplantation. Acta Haematol 1995;94:139-41.
5. Toyosawa M, Shinohara K, Ariyoshi K, Ando T, Kobayashi M, Hikiji K. The detection of minimal residual disease by DEK/CAN chimeric m-RNA in a case of AML M2 with translocation t(6;9)(p23;q34) after chemotherapy and peripheral blood stem cell transplantaion. Rinsho Ketsueki 1997;38:33-40.
6. Boer J, Mahmoud H, Raimondi S, Grosveld G, Krunce R. Loss of the DEK-CAN fusion transcript in a child with t(6;9) acute myeloid leukaemia following chemotherapy and allogeneic bone marrow transplantation. Leukemia 1997;11:299-300.
7. Lillington DM, MacCullum PK, Lister TA, Gibbons B. Translocation t(6;9) (p23;q34) in acute myeloid leukemia without myelodysplasia or basophilia: two cases and a review of the literature. Leukemia 1992;7:527-31.