Loss of the DEK-CAN fusion transcript in a child with t(6;9) acute myeloid leukemia following chemotherapy and allogeneic bone marrow transplantation

Leukemia

Volumn 11, Issue 2, 1997, Pages 299-300

  Boer, J ^a   Mahmoud, H ^a,b   Raimondi, S ^a   Grosveld, G ^a   Krance, R ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

DEK CAN fusion; Reverse transcription polymerase chain reaction; T(6; 9) AML

Indexed keywords

CLADRIBINE; CYCLOSPORIN; CYTARABINE; DAUNORUBICIN; ETOPOSIDE; HYBRID PROTEIN; MESSENGER RNA; PENTOXIFYLLINE;

ACUTE GRANULOCYTIC LEUKEMIA; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER GENETICS; CASE REPORT; CHILD; CHILDHOOD LEUKEMIA; CHROMOSOME 6; CHROMOSOME 9; CHROMOSOME TRANSLOCATION; CYTOGENETICS; GENE FUSION; GRAFT VERSUS HOST REACTION; HUMAN; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL;

EID: 0031051906     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400554     Document Type: Article

References (19)

1. Soekarman D, Von Lindern M, Daenen S et al. The translocation (6;9)(p23;q34) shows consistent rearrangement of two genes and defines a myeloproliferative disorder with specific clinical features. Blood 1992; 79: 1-8.
2. Lillington DM, MacCallum PK, Lister TA, Gibbons B. Translocation t(6;9)(p23;q34) in acute myeloid leukemia without myelodysplasia or basophilia: two cases and a review of the literature. Leukemia 1993; 7: 527-531.
3. Von Lindern M, Fornerod M, van Baal S et al. The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. Mol Cell Biol 1992; 12: 1687-1697.
4. Nakano H, Shimamoto Y, Suga K, Kobayashi M. Detection of minimal residual disease in a patient with acute myeloid leukemia and t(6;9) at the time of peripheral blood stem cell transplantation. Acta Haematol 1995; 94: 139-141.
5. R gene marking. Blood 1995; 86: 433a.
6. Kawasaki ES, Clark SS, Coyne MY et al. Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro. Proc Natl Acad Sci USA 1988; 85: 5698-5702.
7. Roth MS, Antin JH, Bingham EL, Ginsburg D. Detection of Philadelphia chromosome-positive cells by the polymerase chain reaction following bone marrow transplant for chronic myelogenous leukemia. Blood 1989; 74: 882-885.
8. Preudhomme C, Phillipe N, Macintyre E et al. Persistence of AML1/ETO fusion mRNA in t(8;21) acute myeloid leukemia (AML) in prolonged remission: is there a consensus? (letter). Leukemia 1996; 10: 186-188.
9. Radich JP, Gehly G, Gooley T et al. Polymerase chain reaction detection of the BCR-ABL fusion transcript after allogeneic marrow transplantation for chronic myeloid leukemia: results and implications in 346 patients. Blood 1995; 85: 2632-2638.
10. Lo Coco F, Diverio D, Pandolfi PP et al. Molecular evaluation of residual disease as a predictor of relapse in acute promyelocytic leukaemia. Lancet 1992; 340: 1437-1438.
11. Huang W, Sun G-L, Li X-S et al. Acute promyelocytic leukemia: clinical relevance of two major PML-RARa isoforms and detection of minimal residual disease by retrotranscriptase/polymerase chain reaction to predict relapse. Blood 1993; 82: 1264-1269.
12. Miller WH Jr, Levine K, DeBlasio A, Frankel SR, Dmitrovsky E, Warrell RP Jr. Detection of minimal residual disease in acute promyelocytic leukemia by a reverse transcription of polymerase chain reaction assay for the PML/RAR-α fusion mRNA. Blood 1993; 82: 1689-1694.
13. Koller E, Karlic H, Krieger O et al. Early detection of minimal residual disease by reverse transcriptase polymerase chain reaction predicts relapse in acute promyelocytic leukemia. Ann Hematol 1995; 70: 75-78.
14. Nucifora G, Larson RA, Rowley JD. Persistence of the 8;21 translocation in patients with acute myeloid leukemia type M2 in longterm remission. Blood 1993; 82: 712-715.
15. Miyamura K, Tahara T, Tanimoto M et al. Long persistent bcr-abl positive transcript detected by polymerase chain reaction after marrow transplant for chronic myelogenous leukemia without clinical relapse: a study of 64 patients. Blood 1993; 81: 1089-1093.
16. Maruyama F, Stass SA, Estey EH et al. Detection of AML1/ETO fusion transcript as a tool for diagnos̀is t(8;21) positive acute myelogenous leukemia. Leukemia 1994; 8: 40-45.
17. Tobal K, Saunders MJ, Grey MR, Liu Yin JA. Persistence of RARα-PML fusion mRNA detected by reverse transcriptase polymerase chain reaction in patients in long-term remission of acute promyelocytic leukaemia. Br J Haematol 1995; 90: 615-618.
18. Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetracyclin-responsive promoters. Proc Natl Acad Sci USA 1992; 89: 5547-5551.
19. Fornerod M, Boer J, van Baal S et al. Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements. Oncogene 1995; 10: 1739-1748.