Gts1p stabilizes oscillations in energy metabolism by activating the transcription of TPS1 encoding trehalose-6-phosphate synthase 1 in the yeast Saccharomyces cerevisiae

Biochemical Journal

Volumn 383, Issue 1, 2004, Pages 171-178

  Xu, Zhaojun ^a   Yaguchi, So Ichi ^a   Tsurugi, Kunio ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

GTS1; Snf1 kinase; SUC2; TPS1; Transcriptional activator; Ultradian oscillation

Indexed keywords

ACTIVATION ANALYSIS; GENES; GLUCOSE; METABOLISM; RNA; YEAST;

ENERGY METABOLISMS; FLUCTUATIONS; TREHALOSE;

ENZYMES;

ADENINE NUCLEOTIDE; BETA FRUCTOFURANOSIDASE; GLUCOSE; HEAT SHOCK PROTEIN 104; TREHALOSE; TREHALOSE 6 PHOSPHATE SYNTHASE 1; UNCLASSIFIED DRUG;

ARTICLE; BATCH CELL CULTURE; CARBOHYDRATE SYNTHESIS; CELL ENERGY; CELL RESPIRATION; CONTINUOUS CULTURE; ENERGY METABOLISM; FERMENTATION TECHNIQUE; FUNGAL GENE; FUNGUS CULTURE; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GLYCOLYSIS; GTS1P GENE; HEAT TOLERANCE; NONHUMAN; OSCILLATION; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE; SNF1 KINASE GENE; SUC2 GENE; TPS1 GENE; TRANSCRIPTION INITIATION;

ADENINE NUCLEOTIDES; BETA-FRUCTOFURANOSIDASE; ENERGY METABOLISM; GENE EXPRESSION REGULATION, FUNGAL; GLUCOSYLTRANSFERASES; HEAT-SHOCK PROTEINS; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

FUNGI; PROKARYOTA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 6344243202     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040967     Document Type: Article

References (34)

1. Yaguchi, S., Mitsui, K., Kawabata, K., Xu, Z. and Tsurugi, K. (1996) The pleiotropic effect of the GTS1 gene product on heat tolerance, sporulation and the life span of Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 218, 234-237
2. Wang, J., Liu, W., Mitsui, K. and Tsurugi, K. (2001) Evidence for the involvement of the GTS1 gene product in the regulation of biological rhythms in the continuous culture of the yeast Saccharomyces cerevisiae. FEBS Lett. 489, 81-86
3. Hardie, D. G., Carling, D. and Carlson, M. (1998) The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu. Rev. Biochem. 67, 821-855
4. Yaguchi, S. and Tsurugi, K. (2003) Gts 1p activates SNF1-dependent derepression of HSP104 and TPS1 in the stationary phase of yeast growth. J. Biol. Chem. 278, 29760-29768
5. Piper, P. (1997) The yeast heat shock response. In Yeast Stress Responses (Hohmann, S. and Mager, W. H., eds.), pp. 75-99, Landes, Austin, TX
6. Singer, M. A. and Lindquist, S. (1998) Thermotolerance in Saccharomyces cerevisiae: the Yin and Yang of trehalose. Trends Biotechnol. 16, 460-468
7. Kuchin, S., Treich, I. and Carlson, M. (2000) A regulatory shortcut between the Snf1 protein kinase and RNA polymerase II holoenzyme. Proc. Natl. Acad. Sci. U.S.A. 97, 7916-7920
8. Akiyama, S. and Tsurugi, K. (2003) The GTS1 gene product facilitates the self-organization of the energy-metabolism oscillation in the continuous culture of the yeast Saccharomyces cerevisiae. FEMS Microbiol. Lett. 228, 105-110
9. Porro, D., Martegani, E., Ranzi, B. M. and Alberghina, L. (1988) Oscillations in continuous cultures of budding yeast: a segregated parameter analysis. Biotechnol. Bioeng. 32, 411-417
10. Wang, J., Liu, W., Uno, T., Tonozuka, H., Mitsui, K. and Tsurugi, K. (2000) Cellular stress responses oscillate in synchronization with the ultradian oscillation of energy metabolism in the yeast Saccharomyces cerevisiae. FEMS Microbiol. Lett. 189, 9-13
11. Tonozuka, H., Wang, J., Mitsui, K., Saito, T., Hamada, Y. and Tsurugi, K. (2001) Analysis of the upstream regulatory region of the GTS1 gene required for its oscillatory expression. J. Biochem. (Tokyo) 130, 589-595
12. Uno, T., Wang, J., Mitsui, K., Umetani, K., Tamura, K. and Tsurugi, K. (2002) Ultradian rhythm of trehalose levels coupled to heat resistance in continuous cultures of the yeast Saccharomyces cerevisiae. Chronobiol. Int. 19, 361-375
13. Thevelein, J. M. and Hohmann, S. (1995) Trehalose synthase: guard to the gate of glycolysis in yeast? Trends Biochem. Sci. 20, 3-10
14. Francois, J. and Parrou, J. L. (2001) Reserve carbohydrates metabolism in the yeast Saccharomyces cerevisiae. FEMS Microbioi. Rev. 25, 125-145
15. Hardie, D. G. and Hawley, S. A. (2001) AMP-activated protein kinase: the energy charge hypothesis revisited. BioEssays 23, 1112-1119
16. Cortassa, S. and Aon, M. A. (1998) The onset of fermentative metabolism in continuous cultures depends on the catabolite repression properties of Saccharomyces cerevisiae. Enzyme Microbial Technol. 22, 705-712
17. Rouwenhorst, R. J., Van der Baan, A. A., Scheffers, W. A. and Van Dijken, J. P. (1991) Production and localization of β-fructose in asynchronous and synchronous chemostat cultures of yeasts. Appl. Environ. Microbiol. 57, 557-562
18. Gancedo, J. M. (1992) Carbon catabolite repression in yeast. Eur. J. Biochem. 206, 297-313
19. Ronne, H. (1995) Glucose repression in fungi. Trends Genet. 11, 12-17
20. Carlson, M. (1999) Glucose repression in yeast. Curr. Opin. Microbiol. 2, 202-207
21. Yaguchi, S., Mitsui, K. and Tsurugi, K. (2000) Phosphorylation of the GTS1 gene product of the yeast Saccharomyces cerevisiae and its effect on heat tolerance and flocculation. FEMS Microbiol. Lett. 187, 179-184
22. Parulekar, S. J., Semones, G. B., Rolf, M. J., Lievense, J. C. and Lim, H. C. (1986) Induction and elimination of oscillations in continuous cultures of Saccharomyces cerevisiae. Biotechnol. Bioeng. 28, 700-710
23. Martegani, E., Porro, D., Ranzi, B. M. and Alberghina, L. (1990) Involvement of a cell size control mechanism in the induction and maintenance of oscillations in continuous cultures of budding yeast. Biotechnol. Bioeng. 36, 453-459
24. Goldstein, A. and Lampen, J. O. (1975) β-D-Fructofuranoside fructohydrolase from yeast. Methods Enzymol. 42, 504-511
25. Wilson, W. A., Hawley, S. A. and Hardie, D. G. (1996) Glucose repression/derepression in budding yeast: SWF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio. Curr. Biol. 6, 1426-1434
26. McCartney, R. R. and Schmidt, M. C. (2001) Regulation of Snf1 kinase. Activation requires phosphorylation of threonine 210 by an upstream kinase as well as a distinct step mediated by the Snf4 subunit. J. Biol. Chem. 276, 36460-36466
27. Teusink, B., Walsh, M. C., van Dam, K. and Westerhoff, H. V. (1998) The danger of metabolic pathways with turbo design. Trends Biochem. Sci. 23, 162-169
28. Woods, A., Munday, M. R., Scott, J., Yang, X., Carlson, M. and Carling, D. (1995) Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo. J. Biol. Chem. 269, 19509-19515
29. Kievecz, R. R., Bolen, J., Forrest, G. and Murray, D. B. (2004) A genomewide oscillation in transcription gates DNA replication and cell cycle. Proc. Natl. Acad. Sci. U.S.A. 101, 1200-1205
30. Satroutdinov, A. D., Kuriyama, H. and Kobayashi, H. (1992) Oscillatory metabolism of Saccharomyces cerevisiae in continuous culture. FEMS Microbiol. Lett. 77, 261-267
31. Keulers, M., Satroutdinov, A. D., Suzuki, T. and Kuriyama, H. (1996) Synchronization affector of autonomous short-period sustained oscillation of Saccharomyces cerevisiae. Yeast 12, 673-682
32. Sohn, H. Y., Murray, D. B. and Kuriyama, H. (2000) Ultradian oscillation of Saccharomyces cerevisiae during aerobic continuous culture: hydrogen sulphide mediates population synchrony. Yeast 16, 1185-1190
33. Liu, W., Wang, J., Mitsui, K., Shen, H. and Tsurugi, K. (2002) Interaction of the GTS1 gene product with glyceraldehyde-3-phosphate dehydrogenase 1 required for the maintenance of the metabolic oscillations of the yeast Saccharomyces cerevisiae. Eur. J. Biochem. 269, 3560-3569
34. Adams, C. A., Kuriyama, H., Lloyd, D. and Murray, D. B. (2003) The Gts1 protein stabilizes the autonomous oscillator in yeast. Yeast 20, 463-470