Dose-dependent increase or decrease of somatic intrachromosomal recombination produced by etoposide

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 500, Issue 1-2, 2002, Pages 117-124

  Hooker, Antony M ^a   Home, Rachael ^a   Morley, Alexander A ^a   Sykes, Pamela J ^a  

^a FLINDERS UNIVERSITY   (Australia)

Author keywords

Etoposide; Intrachromosomal recombination; Mutation; Transgenic mutagenesis model

Indexed keywords

ETOPOSIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMOSOME INVERSION; CONTROLLED STUDY; DOSE RESPONSE; GENETIC RECOMBINATION; GENOTOXICITY; HYBRIDOMA CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; TRANSGENIC MOUSE; TUMOR MODEL;

ANIMALIA;

EID: 0037139217     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(02)00007-6     Document Type: Article

References (26)

1. Etoposide (VP-16): Cytogenetic studies in mice
2. DNA damage caused by etoposide and γ-irradiation induces gene conversion of the MHC in a mouse non-germline testis cell line
3. Secondary acute myeloid leukemia in children previously treated with alkylating agents, intercalating topoisomerase-II inhibitors, and irradiation
4. Etoposide (VP-16) and teniposide (VM-26): Novel anticancer drugs, strongly mutagenic in mammalian but not in prokaryotic test systems
5. Potent clastogenicity of the human carcinogen etoposide to the mouse bone marrow and mouse lymphoma L5178Y cells: Comparison to Salmonella responses
6. Effects of etoposide on stage-specific DNA synthesis during rat spermatogenesis
7. Etoposide (VP-16) is a potent inducer of micronuclei in male rat meiosis: Spermatid micronucleus test and DNA flow cytometry after etoposide treatment
8. Possible role for p34cdc2 kinase in etoposide-induced cell death of Chinese hamster ovary cells
9. Teratogenic and cytogenetic effects of some plant-derived anti-tumour agents in mice
10. Mutagenic responses of 13 anticancer drugs on mutation induction at multiple genetic loci and on sister chromatid exchanges in Chinese hamster ovary cells
11. Sister chromatid exchanges, chromosomal aberrations and cytotoxicity produced by topoisomerase II inhibition in sensitive (DC 3F) and resistant (DC 3F/90 HE) Chinese hamster cells
12. Inhibition of etoposide (VP-16) induced DNA recombination and mutant frequency by bcl-2 protein overexpression
13. Etoposide causes illegitimate V(D)J recombination in human lymphoid cells
14. Induction of somatic intrachromosomal recombination inversion events by cyclophosphamide in a transgenic mouse model
15. Inversion due to intrachromosomal recombination produced by carcinogens in a transgenic mouse model
16. Detection of somatic DNA recombination in the transgenic mouse brain
17. Effect of 900 MHz radio frequency exposure on intrachromosomal recombination in pKZ1 mice
18. Detection of coliform bacteria in water by polymerase chain reaction and gene probes
19. A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines
20. Making and using conventional mouse monoclonal antibodies
21. Genus- and species-specific identification of mycoplasmas by 16s rRNA amplification
22. Animal model of human disease, multiple myeloma
23. Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer
24. Overcompensation stimulation: A mechanism for hormetic effects
25. U-shaped dose-response curves: Their occurrence and implications for risk assessment