Single lipoprotein apheresis session improves cardiac microvascular function in patients with elevated lipoprotein(a): Detection by stress/rest perfusion magnetic resonance imaging

Therapeutic Apheresis and Dialysis

Volumn 13, Issue 2, 2009, Pages 129-137

  Bohl, Steffen ^a,b   Kassner, Ursula ^a   Eckardt, Rahel ^a   Utz, Wolfgang ^b   Mueller Nordhorn, Jacqueline ^a   Busjahn, Andreas ^c   Thomas, Hans Peter ^d   Abdel Aty, Hassan ^b   Klingel, Reinhard ^e   Marcovina, Santica ^f   Dietz, Rainer ^b   Steinhagen Thiessen, Elisabeth ^a   Schulz Menger, Jeanette ^b   Vogt, Anja ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b FRANZ VOLHARD CLINIC   (Germany)

^c HealthTwist GmbH   (Germany)

^d Königin Elisabeth Herzberge Hospital   (Germany)

^e Apheresis Research Institute   (Germany)

^f UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Coronary artery disease; Lipoprotein apheresis; Lipoprotein(a); Magnetic resonance imaging; Myocardial perfusion

Indexed keywords

ADENOSINE; APOLIPOPROTEIN B; CHOLESTEROL; FIBRINOGEN; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN;

ADULT; APHERESIS; ARTICLE; BLOOD RHEOLOGY; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; EXERCISE TEST; FEMALE; FIBRINOGEN BLOOD LEVEL; HEART BLOOD VESSEL; HEART EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE PERFUSION; HEART PERFUSION; HEART STRESS; HEMATOCRIT; HUMAN; LIPOPROTEIN BLOOD LEVEL; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PARAMETER; PERFUSION WEIGHTED IMAGING; PLASMA VISCOSITY; PRIORITY JOURNAL; REST; STATISTICAL SIGNIFICANCE;

ADULT; BLOOD VISCOSITY; CORONARY ARTERY DISEASE; FEMALE; FIBRINOGEN; FOLLOW-UP STUDIES; HEMATOCRIT; HUMANS; LIPOPROTEIN(A); LIPOPROTEINS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PILOT PROJECTS; PLASMAPHERESIS; PROSPECTIVE STUDIES; TIME FACTORS; TREATMENT OUTCOME; VENTRICULAR FUNCTION, LEFT;

EID: 63349111341     PISSN: 17449979     EISSN: 17449987     Source Type: Journal    
DOI: 10.1111/j.1744-9987.2009.00667.x     Document Type: Article

References (31)

1. Craig WY, Neveux LM, Palomaki GE, Cleveland MM, Haddow JE. Lipoprotein(a) as a risk factor for ischemic heart disease: metaanalysis of prospective studies. Clin Chem 1998 44 (11 2301 6.
2. Cremer P, Nagel D, Labrot B et al. Lipoprotein Lp(a) as predictor of myocardial infarction in comparison to fibrinogen, LDL cholesterol and other risk factors: results from the prospective Gottingen Risk Incidence and Prevalence Study (GRIPS). Eur J Clin Invest 1994 24 (7 444 53.
3. Danesh J, Collins R, Peto R. Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies. Circulation 2000 102 (10 1082 5.
4. Nguyen TT, Ellefson RD, Hodge DO, Bailey KR, Kottke TE, Abu-Lebdeh HS. Predictive value of electrophoretically detected lipoprotein(a) for coronary heart disease and cerebrovascular disease in a community-based cohort of 9936 men and women. Circulation 1997 96 (5 1390 7.
5. Bostom AG, Cupples LA, Jenner JL et al. Elevated plasma lipoprotein(a) and coronary heart disease in men aged 55 years and younger. A prospective study. JAMA 1996 276 (7 544 8.
6. McLean JW, Tomlinson JE, Kuang WJ et al. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature 1987 330 (6144 132 7.
7. Brown MS, Goldstein JL. Plasma lipoproteins: teaching old dogmas new tricks. Nature 1987 330 (6144 113 4.
8. Schachinger V, Halle M, Minners J, Berg A, Zeiher AM. Lipoprotein(a) selectively impairs receptor-mediated endothelial vasodilator function of the human coronary circulation. J Am Coll Cardiol 1997 30 (4 927 34.
9. Otto C, Geiss HC, Laubach E, Schwandt P. Effects of direct adsorption of lipoproteins apheresis on lipoproteins, low-density lipoprotein subtypes, and hemorheology in hypercholesterolemic patients with coronary artery disease. Ther Apher 2002 6 (2 130 5.
10. Mellwig KP, Baller D, Gleichmann U et al. Improvement of coronary vasodilatation capacity through single LDL apheresis. Atherosclerosis 1998 139 (1 173 8.
11. Sachais BS, Katz J, Ross J, Rader DJ. Long-term effects of LDL apheresis in patients with severe hypercholesterolemia. J Clin Apher 2005 20 (4 252 5.
12. Straube R, Kingreen H. Lipoprotein (a) immunapheresis in the treatment of familial lipoprotein (a) hyperlipoproteinemia in a patient with coronary heart disease. Ther Apher 1998 2 (3 243 5.
13. Ullrich H, Lackner KJ, Schmitz G. Lipoprotein(a) apheresis in severe coronary heart disease: an immunoadsorption method. Artif Organs 1998 22 (2 135 9.
14. Muehling OM, Jerosch-Herold M, Panse P et al. Regional heterogeneity of myocardial perfusion in healthy human myocardium: assessment with magnetic resonance perfusion imaging. J Cardiovasc Magn Reson 2004 6 (2 499 507.
15. Schwitter J, Nanz D, Kneifel S et al. Assessment of myocardial perfusion in coronary artery disease by magnetic resonance: a comparison with positron emission tomography and coronary angiography. Circulation 2001 103 (18 2230 5.
16. Maher VM, Brown BG, Marcovina SM, Hillger LA, Zhao XQ, Albers JJ. Effects of lowering elevated LDL cholesterol on the cardiovascular risk of lipoprotein(a). JAMA 1995 274 (22 1771 4.
17. Klingel R, Fassbender T, Fassbender C, Gohlen B. From membrane differential filtration to lipidfiltration: technological progress in low-density lipoprotein apheresis. Ther Apher Dial 2003 7 (3 350 8.
18. Messroghli DR, Bainbridge GJ, Alfakih K et al. Assessment of regional left ventricular function: accuracy and reproducibility of positioning standard short-axis sections in cardiac MR imaging. Radiology 2005 235 (1 229 36.
19. Cerqueira MD, Weissman NJ, Dilsizian V et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 2002 105 (4 539 42.
20. Nagel E, Klein C, Paetsch I et al. Magnetic resonance perfusion measurements for the noninvasive detection of coronary artery disease. Circulation 2003 108 (4 432 7.
21. Armstrong VW, Schuff-Werner P, Eisenhauer T, Helmhold M, Stix M, Seidel D. Heparin extracorporeal LDL precipitation (HELP): an effective apheresis procedure for lowering Lp(a) levels. Chem Phys Lipids 1994 67-68 : 315 21.
22. Richter WO, Donner MG, Schwandt P. Three low density lipoprotein apheresis techniques in treatment of patients with familial hypercholesterolemia: a long-term evaluation. Ther Apher 1999 3 (3 203 8.
23. Camici PG, Crea F. Coronary microvascular dysfunction. N Engl J Med 2007 356 (8 830 40.
24. Gould KL, Martucci JP, Goldberg DI et al. Short-term cholesterol lowering decreases size and severity of perfusion abnormalities by positron emission tomography after dipyridamole in patients with coronary artery disease. A potential noninvasive marker of healing coronary endothelium. Circulation 1994 89 (4 1530 8.
25. Jaeger BR, Bengel FM, Odaka K et al. Changes in myocardial vasoreactivity after drastic reduction of plasma fibrinogen and cholesterol: a clinical study in long-term heart transplant survivors using positron emission tomography. J Heart Lung Transplant 2005 24 (12 2022 30.
26. Tamai O, Matsuoka H, Itabe H, Wada Y, Kohno K, Imaizumi T. Single LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humans. Circulation 1997 95 (1 76 82.
27. Muehling OM, Wilke NM, Panse P et al. Reduced myocardial perfusion reserve and transmural perfusion gradient in heart transplant arteriopathy assessed by magnetic resonance imaging. J Am Coll Cardiol 2003 42 (6 1054 60.
28. Panting JR, Gatehouse PD, Yang GZ et al. Abnormal subendocardial perfusion in cardiac syndrome X detected by cardiovascular magnetic resonance imaging. N Engl J Med 2002 346 (25 1948 53.
29. Vermeltfoort IA, Bondarenko O, Raijmakers PG et al. Is subendocardial ischaemia present in patients with chest pain and normal coronary angiograms? A cardiovascular MR study. Eur Heart J 2007 28 (13 1554 8.
30. Bache RJ, McHale PA, Greenfield JC Jr. Transmural myocardial perfusion during restricted coronary inflow in the awake dog. Am J Physiol 1977 232 (6 H645 51.
31. Canty JM Jr., Klocke FJ. Reduced regional myocardial perfusion in the presence of pharmacologic vasodilator reserve. Circulation 1985 71 (2 370 7.