Pleiotrophin expression in human pancreatic cancer and its correlation with clinicopathological features, perineural invasion, and prognosis

Digestive Diseases and Sciences

Volumn 54, Issue 4, 2009, Pages 895-901

  Yao, Jun ^a   Ma, Qingyong ^a   Wang, Liancai ^a   Zhang, Min ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

N syndecan; Pancreatic cancer; Perineural invasion; Pleiotrophin (PTN); Prognosis

Indexed keywords

CA 19-9 ANTIGEN; PLEIOTROPHIN; SYNDECAN; CARRIER PROTEIN; CYTOKINE; SYNDECAN 3; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER INVASION; CANCER SIZE; CANCER SURVIVAL; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DISTANT METASTASIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MALE; NERVE FIBER GROWTH; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PERINEURIUM; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; CASE CONTROL STUDY; INNERVATION; METABOLISM; MIDDLE AGED; MORTALITY; PANCREAS; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; PERIPHERAL NERVE;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, PANCREATIC DUCTAL; CARRIER PROTEINS; CASE-CONTROL STUDIES; CYTOKINES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PANCREAS; PANCREATIC NEOPLASMS; PERIPHERAL NERVES; PROGNOSIS; SYNDECAN-3; TUMOR MARKERS, BIOLOGICAL;

EID: 63249136560     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-008-0433-5     Document Type: Article

References (36)

1. A Richter M Niedergethmann JW Sturm D Lorenz S Post M Trede 2003 Long-term results of partial pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head: 25-year experience World J Surg 27 324 329 10.1007/s00268-002-6659-z
2. M Wagner C Redaelli M Lietz CA Seiler H Friess MW Buchler 2004 Curative resection is the single most important factor determining outcome in patients with pancreatic adenocarcinoma Br J Surg 91 586 594 10.1002/bjs.4484
3. D Li K Xie R Wolff JL Abbruzzese 2004 Pancreatic cancer Lancet 363 1049 1057 10.1016/S0140-6736(04)15841-8
4. D Laheru EM Jaffee 2005 Immunotherapy for pancreatic cancer-science driving clinical progress Nat Rev Cancer 5 459 467 10.1038/nrc1630
5. I Hirai W Kimura K Ozawa S Kudo K Suto H Kuzu 2002 Perineural invasion in pancreatic cancer Pancreas 24 15 25 10.1097/00006676-200201000-00003
6. GO Ceyhan NA Giese M Erkan AG Kerscher MN Wente T Giese 2006 The neurotrophic factor artemin promotes pancreatic cancer invasion Ann Surg 244 274 281 10.1097/01.sla.0000217642.68697.55
7. C Veit F Genze A Menke S Hoeffert TM Gress P Gierschik 2004 Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells Cancer Res 64 5291 5300 10.1158/0008-5472.CAN-04-1112
8. H Hida CG Jung CZ Wu HJ Kim Y Kodama T Masuda 2003 Pleiotrophin exhibits a trophic effect on survival of dopaminergic neurons in vitro Eur J Neurosci 17 2127 2134 10.1046/j.1460-9568.2003.02661.x
9. X Bao T Mikami S Yamada A Faissner T Muramatsu K Sugahara 2005 Heparin-binding growth factor, pleiotrophin, mediates neuritogenic activity of embryonic pig brain-derived chondroitin sulfate/dermatan sulfate hybrid chains J Biol Chem 280 9180 9191 10.1074/jbc.M413423200
10. TF Deuel N Zhang HJ Yeh I Silos-Santiago ZY Wang 2002 Pleiotrophin: a cytokine with diverse functions and a novel signaling pathway Arch Biochem Biophys 397 162 171 10.1006/abbi.2001.2705
11. K Laaroubi J Delbe F Vacherot P Desgranges M Tardieu M Jaye 1994 Mitogenic and in vitro angiogenic activity of human recombinant heparin affin regulatory peptide Growth Factors 10 89 98 10.3109/08977199409010982
12. T Muramatsu 2002 Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis J Biochem 132 359 371
13. FM Peria L Neder SK Marie S Rosemberg SM Oba-Shinjo BO Colli 2007 Pleiotrophin expression in astrocytic and oligodendroglial tumors and its correlation with histological diagnosis, microvascular density, cellular proliferation and overall survival J Neurooncol 84 255 261 10.1007/s11060-007- 9379-2
14. K Kadomatsu T Muramatsu 2004 Midkine and pleiotrophin in neural development and cancer Cancer Lett 204 127 143 10.1016/S0304-3835(03)00450-6
15. KV Lu KA Jong GY Kim J Singh EQ Dia K Yoshimoto 2005 Differential induction of glioblastoma migration and growth by two forms of pleiotrophin J Biol Chem 280 26953 26964 10.1074/jbc.M502614200
16. S Muller P Kunkel K Lamszus U Ulbricht GA Lorente AM Nelson 2003 A role for receptor tyrosine phosphatase zeta in glioma cell migration Oncogene 22 6661 6668 10.1038/sj.onc.1206763
17. H Wu A Barusevicius J Babb A Klein-Szanto A Godwin R Elenitsas 2005 Pleiotrophin expression correlates with melanocytic tumor progression and metastatic potential J Cutan Pathol 32 125 130 10.1111/j.0303-6987.2005.00282.x
18. H Chen MS Gordon RA Campbell M Li CS Wang HJ Lee 2007 Pleiotrophin is highly expressed by myeloma cells and promotes myeloma tumor growth Blood 110 287 295 10.1182/blood-2006-08-042374
19. Y Chang M Zuka P Perez-Pinera A Astudillo J Mortimer JR Berenson 2007 Secretion of pleiotrophin stimulates breast cancer progression through remodeling of the tumor microenvironment Proc Natl Acad Sci USA 104 10888 10893 10.1073/pnas.0704366104
20. D Weber HJ Klomp F Czubayko A Wellstein H Juhl 2000 Pleiotrophin can be rate-limiting for pancreatic cancer cell growth Cancer Res 60 5284 5288
21. HJ Klomp O Zernial S Flachmann A Wellstein H Juhl 2002 Significance of the expression of the growth factor pleiotrophin in pancreatic cancer patients Clin Cancer Res 8 823 827
22. B Souttou H Juhl J Hackenbruck M Rockseisen HJ Klomp D Raulais 1998 Relationship between serum concentrations of the growth factor pleiotrophin and pleiotrophin-positive tumors J Natl Cancer Inst 90 1468 1473 10.1093/jnci/90.19.1468
23. A Kinnunen T Kinnunen M Kaksonen R Nolo P Panula H Rauvala 1998 N-syndecan and HB-GAM (heparin-binding growth-associated molecule) associate with early axonal tracts in the rat brain Eur J Neurosci 10 635 648 10.1046/j.1460-9568.1998.00082.x
24. E Raulo MA Chernousov DJ Carey R Nolo H Rauvala 1994 Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3) J Biol Chem 269 12999 13004
25. T Kinnunen M Kaksonen J Saarinen N Kalkkinen HB Peng H Rauvala 1998 Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth J Biol Chem 273 10702 10708 10.1074/jbc.273.17.10702
26. Z Zhu H Friess FF diMola A Zimmermann HU Graber M Korc 1999 Nerve growth factor expression correlates with perineural invasion and pain in human pancreatic cancer J Clin Oncol 17 2419 2428
27. C Wittekind CC Compton FL Greene LH Sobin 2002 TNM residual tumor classification revisited Cancer 94 2511 2516 10.1002/cncr.10492
28. H Ozaki T Hiraoka R Mizumoto S Matsuno Y Matsumoto T Nakayama 1999 The prognostic significance of lymph node metastasis and intrapancreatic perineural invasion in pancreatic cancer after curative resection Surg Today 29 16 22 10.1007/BF02482964
29. A Nakao A Harada T Nonami T Kaneko H Takagi 1996 Clinical significance of carcinoma invasion of the extrapancreatic nerve plexus in pancreatic cancer Pancreas 12 357 361 10.1097/00006676-199605000-00006
30. M Kayahara H Nakagawara H Kitagawa T Ohta 2007 The nature of neural invasion by pancreatic cancer Pancreas 35 218 223
31. T Takahashi H Ishikura T Motohara S Okushiba M Dohke H Katoh 1997 Perineural invasion by ductal adenocarcinoma of the pancreas J Surg Oncol 65 164 170
32. I Miyazaki 1997 Perineural invasion and surgical treatment of the pancreas head cancer Nippon Geka Gakkai Zasshi 98 646 648
33. Sudo T, Murakami Y, Uemura K, Hayashidani Y, Hashimoto Y, Ohge H, et al (2008) Prognostic impact of perineural invasion following pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma. Dig Dis Sci
34. S Mitsunaga T Hasebe T Kinoshita M Konishi S Takahashi N Gotohda 2007 Detail histologic analysis of nerve plexus invasion in invasive ductal carcinoma of the pancreas and its prognostic impact Am J Surg Pathol 31 1636 1644
35. SQ Yi K Miwa T Ohta M Kayahara H Kitagawa A Tanaka 2003 Innervation of the pancreas from the perspective of perineural invasion of pancreatic cancer Pancreas 27 225 229 10.1097/00006676-200310000-00005
36. H Rauvala HJ Huttunen C Fages M Kaksonen T Kinnunen S Imai 2000 Heparin-binding proteins HB-GAM (pleiotrophin) and amphoterin in the regulation of cell motility Matrix Biol 19 377 387 10.1016/S0945-053X(00)00084-6