Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic Caucasians

Clinical Endocrinology

Volumn 70, Issue 5, 2009, Pages 698-705

  Qasim, Atif N ^b   Metkus, Thomas S ^b   Tadesse, Mahlet ^c   Lehrke, Michael ^d   Restine, Stephanie ^b   Wolfe, Megan L ^b   Hannenhalli, Sridhar ^b   Cappola, Thomas ^b   Rader, Daniel J ^b   Reilly, Muredach P ^a,b  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

^d Department of Gastroenterology Endocrinology and Metabolism Munich ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; RESISTIN;

ADULT; ALLELE; ARTICLE; CAUCASIAN; CORONARY ARTERY ATHEROSCLEROSIS; FEMALE; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPOKINES; ADIPOSITY; ADULT; BIOLOGICAL MARKERS; CORONARY ARTERY DISEASE; CYTOKINES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC VARIATION; HAPLOTYPES; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LINKAGE DISEQUILIBRIUM; MALE; METABOLIC SYNDROME X; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RESISTIN;

EID: 63149193465     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2008.03375.x     Document Type: Article

References (41)

1. Steppan, C.M., Bailey, S.T., Bhat, S. et al. (2001) The hormone resistin links obesity to diabetes. Nature, 409, 307 312.
2. Kim, K.H., Lee, K., Moon, Y.S. et al. (2001) A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. Journal of Biological Chemistry, 276, 11252 11256.
3. Rangwala, S.M., Rich, A.S., Rhoades, B. et al. (2004) Abnormal glucose homeostasis due to chronic hyperresistinemia. Diabetes, 53, 1937 1941.
4. Satoh, H., Nguyen, M.T., Miles, P.D. et al. (2004) Adenovirus-mediated chronic 'hyper-resistinemia' leads to in vivo insulin resistance in normal rats. Journal of Clinical Investigation, 114, 224 231.
5. Steppan, C.M. Lazar, M.A. (2004) The current biology of resistin. Journal of Internal Medicine, 255, 439 447.
6. Azuma, K., Katsukawa, F., Oguchi, S. et al. (2003) Correlation between serum resistin level and adiposity in obese individuals. Obesity Research, 11, 997 1001.
7. McTernan, P.G., Fisher, F.M., Valsamakis, G. et al. (2003) Resistin and type 2 diabetes: regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes. Journal of Clinical Endocrinology and Metabolism, 88, 6098 6106.
8. Lee, J.H., Chan, J.L., Yiannakouris, N. et al. (2003) Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects. Journal of Clinical Endocrinology and Metabolism, 88, 4848 4856.
9. Utzschneider, K.M., Carr, D.B., Tong, J. et al. (2005) Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans. Diabetologia, 48, 2330 2333.
10. Gerber, M., Boettner, A., Seidel, B. et al. (2005) Serum resistin levels of obese and lean children and adolescents: biochemical analysis and clinical relevance. Journal of Clinical Endocrinology and Metabolism, 90, 4503 4509.
11. Yang, R.Z., Huang, Q., Xu, A. et al. (2003) Comparative studies of resistin expression and phylogenomics in human and mouse. Biochemical and Biophysical Research Communications, 310, 927 935.
12. Kaser, S., Kaser, A., Sandhofer, A. et al. (2003) Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro. Biochemical and Biophysical Research Communications, 309, 286 290.
13. Reilly, M.P., Lehrke, M., Wolfe, M.L. et al. (2005) Resistin is an inflammatory marker of atherosclerosis in humans. Circulation, 111, 932 939.
14. Migita, K., Maeda, Y., Miyashita, T. et al. (2006) The serum levels of resistin in rheumatoid arthritis patients. Clinical and Experimental Rheumatology, 24, 698 701.
15. Axelsson, J., Bergsten, A., Qureshi, A.R. et al. (2006) Elevated resistin levels in chronic kidney disease are associated with decreased glomerular filtration rate and inflammation, but not with insulin resistance. Kidney International, 69, 596 604.
16. Burnett, M.S., Lee, C.W., Kinnaird, T.D. et al. (2005) The potential role of resistin in atherogenesis. Atherosclerosis, 182, 241 248.
17. Menzaghi, C., Coco, A., Salvemini, L. et al. (2006) Heritability of serum resistin and its genetic correlation with insulin resistance-related features in nondiabetic Caucasians. Journal of Clinical Endocrinology and Metabolism, 91, 2792 2795.
18. Conneely, K.N., Silander, K., Scott, L.J. et al. (2004) Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects. Diabetologia, 47, 1782 1788.
19. Mattevi, V.S., Zembrzuski, V.M. Hutz, M.H. (2004) A resistin gene polymorphism is associated with body mass index in women. Human Genetics, 115, 208 212.
20. Xu, J.Y., Sham, P.C., Xu, A. et al. (2007) Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5-year prospective study. Clinical Endocrinology, 66, 211 217.
21. Norata, G.D., Ongari, M., Garlaschelli, K. et al. (2007) Effect of the -420C/G variant of the resistin gene promoter on metabolic syndrome, obesity, myocardial infarction and kidney dysfunction. Journal of Internal Medicine, 262, 104 112.
22. Cho, Y.M., Youn, B.S., Chung, S.S. et al. (2004) Common genetic polymorphisms in the promoter of resistin gene are major determinants of plasma resistin concentrations in humans. Diabetologia, 47, 559 565.
23. Osawa, H., Yamada, K., Onuma, H. et al. (2004) The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3. American Journal of Human Genetics, 75, 678 686.
24. Reilly, M.P., Wolfe, M.L., Localio, A.R. et al. (2003) C-reactive protein and coronary artery calcification. The Study of Inherited Risk of Coronary Atherosclerosis (SIRCA). Arteriosclerosis, Thrombosis, and Vascular Biology, 23, 1851 1856.
25. Wilson, P.W., D'Agostino, R.B., Levy, D. et al. (1998) Prediction of coronary heart disease using risk factor categories. Circulation, 97, 1837 1847.
26. Grundy, S.M., Cleeman, J.I., Daniels, S.R. et al. (2005) Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Executive summary. Cardiology in Review, 13, 322 327.
27. Matthews, D.R., Hosker, J.P., Rudenski, A.S. et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28, 412 419.
28. Purcell, S., Cherny, S.S. Sham, P.C. (2003) Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics, 19, 149 150.
29. Burkett, K. Graham, J. (2007) Likelihood inference of trait associations with SNP haplotypes and other attributes using the EM algorithm. The hapassoc package. Available at: http://stat-db.stat.sfu.ca:8080/statgen/research/hapassoc (accessed 03 September 2008).
30. Osawa, H., Tabara, Y., Kawamoto, R. et al. (2007) Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population. Diabetes Care, 30, 1501 1506.
31. Dolinkova, M., Krizova, J., Lacinova, Z. et al. (2006) Polymorphisms of adiponectin and resistin genes in patients with obesity and anorexia nervosa [in Czech]. Casopis Lekaru Ceskych, 145, 562 566.
32. Spielman, R.S., Bastone, L.A., Burdick, J.T. et al. (2007) Common genetic variants account for differences in gene expression among ethnic groups. Nature Genetics, 39, 226 231.
33. Kaytor, E.N., Zhu, J.L., Pao, C.I. et al. (2001) Insulin-responsive nuclear proteins facilitate Sp1 interactions with the insulin-like growth factor-I gene. Journal of Biological Chemistry, 276, 36896 36901.
34. Nagaev, I., Bokarewa, M., Tarkowski, A. et al. (2006) Human resistin is a systemic immune-derived proinflammatory cytokine targeting both leukocytes and adipocytes. PLoS ONE, 1, e31.
35. Steppan, C.M., Wang, J., Whiteman, E.L. et al. (2005) Activation of SOCS-3 by resistin. Molecular and Cellular Biology, 25, 1569 1575.
36. Kunnari, A., Ukkola, O. Kesaniemi, Y.A. (2005) Resistin polymorphisms are associated with cerebrovascular disease in Finnish type 2 diabetic patients. Diabetic Medicine, 22, 583 589.
37. Engert, J.C., Vohl, M.C., Williams, S.M. et al. (2002) 5′ flanking variants of resistin are associated with obesity. Diabetes, 51, 1629 1634.
38. Pizzuti, A., Argiolas, A., Di Paola, R. et al. (2002) An ATG repeat in the 3′-untranslated region of the human resistin gene is associated with a decreased risk of insulin resistance. Journal of Clinical Endocrinology and Metabolism, 87, 4403 4406.
39. Anderson, P.D., Mehta, N.N., Wolfe, M.L. et al. (2007) Innate immunity modulates adipokines in humans. Journal of Clinical Endocrinology and Metabolism, 92, 2272 2279.
40. Lubos, E., Messow, C.M., Schnabel, R. et al. (2007) Resistin, acute coronary syndrome and prognosis results from the AtheroGene study. Atherosclerosis, 193, 121 128.
41. Tang, N.P., Wang, L.S., Yang, L. et al. (2008) A polymorphism in the resistin gene promoter and the risk of coronary artery disease in a Chinese population. Clinical Endocrinology, 68, 82 87.