Effects of BT-11 on memory in healthy humans

Neuroscience Letters

Volumn 454, Issue 2, 2009, Pages 111-114

  Lee, Jun Young ^a   Kim, Ka Young ^b   Shin, Ki Young ^b   Won, Beom Young ^b   Jung, Hee Yeon ^a   Suh, Yoo Hun ^b  

^a Seoul National University Boramae Hospital   (South Korea)

^b National Creative Research Initiative Center for Alzheimer's Dementia   (South Korea)

Author keywords

BT 11; K CVLT; Memory; Polygala tenuifolia; SOPT

Indexed keywords

BT 11; NEUROPROTECTIVE AGENT; PLACEBO; PLANT EXTRACT; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DYSPEPSIA; HUMAN; LEARNING TEST; NORMAL HUMAN; POLYGALA TENUIFOLIA WILLDENOW; POLYGALACEAE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VERBAL MEMORY; WORKING MEMORY;

ADULT; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MEMORY; MEMORY, SHORT-TERM; MENTAL RECALL; NEUROPSYCHOLOGICAL TESTS; NOOTROPIC AGENTS; PHYTOTHERAPY; PLANT EXTRACTS; POLYGALA; RECOGNITION (PSYCHOLOGY);

EID: 63149164808     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.03.024     Document Type: Article

References (18)

1. Bacopa monniera, Monograph, Altern. Med. Rev. (2004) 79-85.
2. Calabrese C., Gregory W.L., Leo M., Kraemer D., Bone K., and Oken B. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. J. Altern. Complement. Med. 14 (2008) 707-713
3. Das A., Shanker G., Nath C., Pal R., Singh S., and Singh H. A comparative study in rodents of standardized extracts of Bacopa monniera and Ginkgo biloba: anticholinesterase and cognitive enhancing activities. Pharmacol. Biochem. Behav. 73 (2002) 893-900
4. Davis K.L., Mohs R.C., Tinklenberg J.R., Hollister L.E., Pfefferbaum A., and Kopell B.S. Cholinomimetics memory. The effect of choline chloride. Arch. Neurol. 37 (1980) 49-52
5. de Quervain D.J., Roozendaal B., and McGaugh J.L. Stress and glucocorticoids impair retrieval of long-term spatial memory. Nature 394 (1998) 787-790
6. D.C. Delis, J.H. Kramer, E. Kaplan, B.A. Ober, The California Verbal Learning Test, Research Edition. New York: Psychological Corporation (1987).
7. Furey M.L., Pietrini P., Alexander G.E., Schapiro M.B., and Horwitz B. Cholinergic enhancement improves performance on working memory by modulating the functional activity in distinct brain regions: a positron emission tomography regional cerebral blood flow study in healthy humans. Brain Res. Bull. 51 (2000) 213-218
8. He Z., Liao Y., Zheng M., Zeng F.D., and Guo L.J. Piracetam improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Cell. Mol. Neurobiol. 28 (2008) 613-627
9. Kim J.K., and Kang Y. Normative study of the Korean-California Verbal Learning Test (K-CVLT). Clin. Neuropsychol. 13 (1999) 365-369
10. Lanni C., Lenzken S.C., Pascale A., Del Vecchio I., Racchi M., Pistoia F., and Govoni S. Cognition enhancers between treating and doping the mind. Pharmacol. Res. 57 (2008) 196-213
11. Nathan P.J., Tanner S., Lloyd J., Harrison B., Curran L., Oliver C., and Stough C. Effects of a combined extract of Ginkgo biloba and Bacopa monniera on cognitive function in healthy humans. Hum. Psychopharmacol. 19 (2004) 91-96
12. Park C.H., Choi S.H., Koo J.W., Seo J.H., Kim H.S., Jeong S.J., and Suh Y.H. Novel cognitive improving and neuroprotective activities of Polygala tenuifolia Willdenow extract, BT-11. J. Neurosci. Res. 70 (2002) 484-492
13. Petrides M., and Milner B. Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man. Neuropsychologia 20 (1982) 249-262
14. Pilch H., and Müller W.E. Piracetam elevates muscarinic cholinergic receptor density in the frontal cortex of aged but not of young mice. Psychopharmacology 94 (1998) 74-78
15. Rusted J., and Eaton-Williams P. Distinguishing between attentional and amnestic effects in information processing: the separate and combined effects of scopolamine and nicotine on verbal free recall. Psychopharmacology 104 (1991) 363-366
16. Shin K.Y., Won B.Y., Heo C., Kim H.J., Jang D.P., Park C.H., Kim S., Kim H.S., Kim Y.B., Lee H.G., Lee S.H., Cho Z.H., and Suh Y.H. BT-11 improves stress-induced memory impairments through increment of glucose utilization and total neural cell adhesion molecule levels in rat brains. J. Neurosci. Res. (2008)
17. Stoll L., Schubert T., and Müller W.E. Age-related deficits of central muscarinic cholinergic receptor function in the mouse: partial restoration by chronic piracetam treatment. Neurobiol. Aging 13 (1992) 39-44
18. Stough C., Downey L.A., Lloyd J., Silber B., Redman S., Hutchison C., Wesnes K., and Nathan P.J. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Phytother. Res. (2008)