EGCG inhibits proliferation of cardiac fibroblasts in rats with cardiac hypertrophy

Planta Medica

Volumn 75, Issue 2, 2009, Pages 113-120

  Sheng, Rui ^a   Gu, Zhen Lun ^a   Xie, Mei Lin ^a   Zhou, Wen Xuan ^a   Guo, Ci Yi ^a  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

Author keywords

Cardiac fibroblasts; Cardiac hypertrophy; Epigallocatechin gallate (EGCG); Nitric oxide; Proliferation

Indexed keywords

ANGIOTENSIN II; CAPTOPRIL; EPIGALLOCATECHIN GALLATE; HYDROXYPROLINE; MYC PROTEIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRITE; ANTIOXIDANT; ATRIAL NATRIURETIC FACTOR; CATECHIN; CYCLINE; DNA BINDING PROTEIN; DRUG DERIVATIVE; ENDOTHELIN; ENZYME INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; MYCBP PROTEIN, HUMAN; PLANT EXTRACT; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; AORTA CONSTRICTION; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FIBROBLAST; HEART HYPERTROPHY; HEART MUSCLE FIBROSIS; HEART PROTECTION; HEART WEIGHT; IN VITRO STUDY; IN VIVO STUDY; MALE; MEDICINAL PLANT; NONHUMAN; RAT; WESTERN BLOTTING; ANIMAL; CARDIOMEGALY; CYTOLOGY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; FIBROSIS; HEART MUSCLE; METABOLISM; ORGAN SIZE; PATHOLOGY; SPRAGUE DAWLEY RAT; TEA;

RATTUS;

ANGIOTENSIN II; ANIMALS; ANTIOXIDANTS; ATRIAL NATRIURETIC FACTOR; CAMELLIA SINENSIS; CARDIOMEGALY; CATECHIN; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELINS; ENZYME INHIBITORS; FIBROBLASTS; FIBROSIS; HYDROXYPROLINE; MALE; MYOCARDIUM; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; ORGAN SIZE; PLANT EXTRACTS; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTION FACTORS;

EID: 63149125593     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0028-1088387     Document Type: Article

References (35)

1. Olivetti G, Cigola E, Maestri R, Lagrasta C, Corradi D, Quaini F. Recent advances in cardiac hypertrophy. Cardiovasc Res 2000; 45: 6-37
2. Brown RD, Ambler SK, Mitchell MD, Long CS. The cardiac fibroblast: therapeutic target in myocardial remodeling and failure. Annu Rev Pharmacol Toxicol 2005; 45: 657-687 (Pubitemid 40261821)
3. Gupta M, Gupta MP, Arcilla RA, Zak R. Cardiomyocytes and non-muscle cells in cardiac hypertrophy: a molecular perspective. Prog Ped Card 1999; 9: 183-197 (Pubitemid 29305357)
4. Chyu KY, Babbidge SM, Zhao X, Dandillaya R, Rietveld AG, Yano J. Differential effects of green tea-derived catechin on developing versus established atherosclerosis in apolipoprotein E-null mice. Circulation 2004; 109: 2448-2453 (Pubitemid 38679566)
5. Townsend PA, Scarabelli TM, Pasini E, Gitti G, Menegazzi M, Suzuki H. Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis. FASEB J 2004; 18: 1621-1623 (Pubitemid 39561653)
6. Sheng R, Gu ZL, Xie ML, Guo CY, Zhou WX. EGCG inhibits cardiomyocyte apoptosis in pressure overload induced cardiac hypertrophy rats and protects cardiomyocyte from oxidative stress. Acta Pharmacol Sin 2007; 28: 191-201 (Pubitemid 46155536)
7. Li HL, Huang Y, Zhang CN, Liu G, Wei YS, Wang AB. Epigallocathechin 3-gallate inhibits cardiac hypertrophy through blocking reactive oxidative species-dependent and -independent signal pathways. Free Radic Biol Med 2006; 40: 1756-1775
8. Shimoyama M, Hayashi D, Takimoto E, Zou YZ, Oka T, Uozumi H. Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophy. Circulation 1999; 100: 2449-2454 (Pubitemid 37411007)
9. Li JL, Li P, Feng XH, Li ZP, Hou R, Han C. Effects of lorsartan on pressure overload-induced cardiac gene expression profiling in rats. Clin Exp Pharmacol Physiol 2003; 30: 827-832 (Pubitemid 37506147)
10. Puyo AM, Vega GW, Dellegrino de IA, Albornoz LE, Roson ML, Scagilia P. Atrial natriuretic peptide in two kidney-two clips renovascular hypertension in the rat. Medicina 1998; 58: 165-170 (Pubitemid 128515997)
11. Modesti PA, Vanni S, Bertolozzi I, Cecinoni I, Polidori G, Paniccia R. Early sequence of cardiac adaptations and growth factor formation in pressure- and volume-overload hypertrophy. Am J Physiol Heart Circ Physiol 2000; 279: H976-85
12. Yang XF, Wang NP, Lu WH, Zeng FD. Effects of Ginkgo biloba extract and tanshinone on cytochrome P-450 isozymes and glutathione transferase in rats. Acta Pharmacol Sin 2003; 24: 1033-1038
13. Rhaleb NE, Peng HM, Harding P, Tayeh M, LaPointe MC, Carretero OA. Effect of N-acetyl-deryl-aspartyl-lysyl- proline on DNA and collagen synthesis in rat cardiac fibroblasts. Hypertension 2001; 37: 827-832
14. Heron MI, Rakusan K. Proliferating cell nuclear antigen (PCNA), detection of cellular proliferation in hypothyroid and hyperthyroid rat hearts. J Mol Cell Cardiol 1995; 27: 1393-1403
15. Maino TA, Cao W, Lee J, Courtey R. Localization of proliferating cell nuclear antigen in the developing and mature rat heart cell. Anat Rec 1996; 245: 677-684 (Pubitemid 26286625)
16. Cao Y, Gu ZL, Lin F, Han R, Qin ZH. Caspase-1 inhibitor Ac-YVAD-CHO attenuates quinolinic acid-induced increases in p53 and apoptosis in rat striatum. Acta Pharmacol Sin 2005; 26: 150-154 (Pubitemid 40203957)
17. Watanabe T, Akishita M, He H, Miyahara Y, Nagano K, Nakaoka T. 17β-Estradiol inhibits cardiac fibroblast growth through both subtypes of estrogen receptor. Biochem Biophys Res Commun 2003; 311: 454-459 (Pubitemid 37340098)
18. Horio T, Nishikimi T, Yoshihara F, Matsuo H, Takishita S, Kangawa K. Effects of adrenomedullin on cultured rat cardiac myocytes and fibroblasts. Eur J Pharmacol 1999; 382: 1-9 (Pubitemid 29518271)
19. Takahashi K, Ouyang X, Komatsu K, Nakamura N, Hattori M, Baba A. Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells. Biochem Pharmacol 2002; 64: 745-750
20. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63 (Pubitemid 14203433)
21. Wang SJ, Wang XX, Yan J, Xie XD, Fan FH, Zhou XH. Resveratrol inhibits proliferation of cultured rat cardiac fibroblasts: Correlated with NO-cGMP signaling pathway. Eur J Pharmacol 2007; 567: 26-35 (Pubitemid 46795491)
22. Kanekar S, Hirozanne T, Terracio L, Borg TK. Cardiac fibroblasts: form and function. Cardiovasc Pathol 1998; 7: 127-133
23. Neforo N, Inariba H, Inoue T, Kanayama Y, Takeda T. Expression of c-myc proto-oncogene in hearts and cultured smooth muscle cells of spontaneously hypertensive rats. J Hypertens Suppl 1988; 6: S128-30 (Pubitemid 19067293)
24. Izumo S, Nadal-Ginard B, Mahdavi V. Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload. Proc Natl Acad Sci USA 1988; 85: 339-343
25. Akers WS, Cross A, Speth R, Dwoskin LP, Cassis LA. Renin-angiotensin system and sympathetic nervous system in cardiac pressure-overload hypertrophy. Am J Physiol Heart Circ Physiol 2000; 279: H2797-806 (Pubitemid 32005868)
26. Brecher P. Angiotensin II and cardiac fibrosis. Trends Cardiovasc Med 1996; 6: 193-198
27. Hou J, Kato H, Cohen RA, Chobanian AV, Brecher P. Angiotensin II-induced cardiac fibrosis in the rat in increased by chronic inhibition of nitric oxide synthase. J Clin Invest 1995; 96: 2469-2477
28. Kim NN, Villegas S, Summerour SR, Villarreal FJ. Regulation of cardiac fibroblast excellular matrix production by bradykinin and nitric oxide. J Mol Cell Cardiol 1999; 31: 457-466 (Pubitemid 29089893)
29. Fan YH, Zhao LY, Zheng QS, Dong H, Wang HC, Yang XD. Arginine vasopressin increases iNOS-NO system activity in cardiac fibroblasts through NF-κB activation and its relation with myocardial fibrosis. Life Sci 2007; 81: 327-335 (Pubitemid 47030575)
30. Lorenz M, Wessler S, Follmann E, Michaelis W, Düsterhöft T, Baumann G. A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-,cAMP- dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation. J Biol Chem 2004; 279: 6190-6195 (Pubitemid 38220652)
31. Lin YL, Lin JK. (-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-κB. Mol Pharmacol 1997; 52: 465-472
32. Song EK, Hur H, Han MK. Epigallocatechin gallate prevents autoimmune diabetes induced by multiple low doses of streptozotocin in mice. Arch Pharm Res 2003; 26: 559-563 (Pubitemid 43073805)
33. Tian B, Liu J, Bitterman P, Bache RJ. Angiotensin II modulates nitric oxide-induced cardiac fibroblast apoptosis by activation of AKT/PKB. Am J Physiol Heart Circ Physiol 2003; 285: H1105-12 (Pubitemid 37048166)
34. Siddiqui IA, Adhami VM, Afaq F, Ahmad N, Mukhtar H. Modulation of phosphatidylinositol-3-kinase/protein kinase B- and mitogen-activated protein kinase-pathways by tea polyphenols in human prostate cancer cells. J Cell Biochem 2004; 91: 232-242
35. Shankar S, Chen Q, Srivastava RK. Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogenic effects of EGCG through activation of FOXO transcription factor. J Mol Signal 2008; 3: 7