Absolute requirement for iron in the development of chemically induced uroporphyria in mice treated with 3-methylcholanthrene and 5-aminolevulinate

BioMetals

Volumn 22, Issue 2, 2009, Pages 345-351

  Nakano, Kenzi ^a   Ishizuka, Mayumi ^a   Sakamoto, Kentaro Q ^a   Fujita, Shoichi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

CYP1A2; Iron; Porphyria; Uroporphyrin; Uroporphyrinogen oxidation

Indexed keywords

3 METHYLCHOLANTHRENE; AMINOLEVULINIC ACID; CYTOCHROME P450 1A2; HEME; IRON; PORPHYRIN; UROPORPHYRINOGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE; IRON DEFICIENCY; LIVER; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PORPHYRIA; PORPHYRINURIA; WESTERN BLOTTING;

AMINOLEVULINIC ACID; ANIMALS; CYTOCHROME P-450 CYP1A2; IRON; MALE; METHYLCHOLANTHRENE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXYGEN; PORPHYRIAS; TIME FACTORS; UROPORPHYRINOGENS; UROPORPHYRINS;

MUS;

EID: 63149096188     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10534-008-9171-6     Document Type: Article

References (31)

1. FT Becker 1965 Porphyria cutanea tarda induced by estrogens Arch Dermatol 92 252 255 10.1001/archderm.92.3.252
2. HL Bonkovsky SG Wood SK Howell PR Sinclair B Lincoln JF Healey JF Sinclair 1986 High-performance liquid chromatographic separation and quantitation of tetrapyrroles from biological materials Anal Biochem 155 56 64 10.1016/0003-2697(86)90224-1
3. MD Burke S Thompson CR Elcombe J Halpert T Haaparanta RT Mayer 1985 Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450 Biochem Pharmacol 34 3337 3345 10.1016/0006-2952(85)90355-7
4. G Chaufan MC Rios de Molina LCSM de Viale 2001 How does hexachlorobenzene treatment affect liver uroporphyrinogen decarboxylase? Int J Biochem Cell Biol 33 621 630 10.1016/S1357-2725(01)00034-6
5. MA Clark BA Bing PE Gottschall JF Williams 1995 Differential effect of cytokines on the phenobarbital or 3-methylcholanthrene induction of P450 mediated monooxygenase activity in cultured rat hepatocytes Biochem Pharmacol 49 97 104 10.1016/0006-2952(94)00438-R
6. S Deam GH Elder 1991 Uroporphyria produced in mice by iron and 5-aminolevulinic acid Biochem Pharmacol 41 12 2019 2022
7. R Enriquez de Salamanca D Mingo S Chinarro JJ Munoz J Perpina 1982 Patterns of porphyrin-excretion in female estrogen-induced porphyria cutanea tarda Arch Dermatol Res 274 179 184 10.1007/BF00510371
8. JH Epstein AG Redeker 1965 Porphyria cutanea tarda symptomatica (PCT-S). A study of the effect of phlebotomy therapy Arch Dermatol 92 286 289 10.1001/archderm.92.3.286
9. JE Francis AG Smith 1984 Assay of mouse liver uroporphyrinogen decarboxylase by reverse-phase high-performance liquid chromatography Anal Biochem 138 404 410 10.1016/0003-2697(84)90829-7
10. N Gorman HS Walton WJ Bement CP Honsinger JG Szakacs JF Sinclair PR Sinclair 1999 Role of small differences in CYP1A2 in the development of uroporphyria produced by iron and 5-aminolevulinate in C57BL/6 and SWR strains of mice Biochem Pharmacol 58 375 382 10.1016/S0006-2952(99)00088-X
11. N Gorman KL Ross HS Walton WJ Bement JG Szakacs GS Gerhard TP Dalton DW Nebert RS Eisenstein JF Sinclair PR Sinclair 2002 Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron Hepatology 35 912 921 10.1053/jhep.2002.32487
12. JF Jarrell A Gocmen D Akyol R Brant 2002 Hexachlorobenzene exposure and the proportion of male births in Turkey 1935-1990 Reprod Toxicol 16 65 70 10.1016/S0890-6238(01)00196-4
13. KG Jones GD Sweeney 1977 Association between induction of aryl hydrocarbon hydroxylase and depression of uroporphyrinogen decarboxylase activity Res Commun Chem Pathol Pharmacol 17 631 637
14. RW Lambrecht JM Jacobs PR Sinclair JF Sinclair 1990 Inhibition of uroporphyrinogen decarboxylase activity. The role of cytochrome P-450-mediated uroporphyrinogen oxidation Biochem J 269 437 441
15. RW Lambrecht PR Sinclair N Gorman JF Sinclair 1992 Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2 Arch Biochem Biophys 294 504 510 10.1016/0003-9861(92)90717-B
16. OH Lowry HJ Rosebrough AL Farr RJ Randall 1951 Protein measurement with the Folin phenol reagent J Biol Chem 193 265 275
17. S Nonaka T Ohgami F Murayama K Yamashita H Yoshida 1986 Five cases of porphyria cutanea tarda with mild cutaneous changes: evaluation of the efficacy of phlebotomy by the pattern analysis of urinary porphyrins J Dermatol 13 196 202
18. T Omura R Sato 1964 The carbon monooxide-binding pigment of liver microsomes J Biol Chem 239 370 2378
19. JD Phillips LK Jackson M Bunting MR Franklin KR Thomas JE Levy NC Andrews JP Kushner 2001 A mouse model of familial porphyria cutanea tarda Proc Natl Acad Sci USA 98 259 264 10.1073/pnas.011481398
20. N Schoenfeld R Mamet L Leibovici A Lanir 1996 Alcohol-induced changes in urinary aminolevulinic acid and porphyrins: unrelated to liver disease Alcohol 13 59 63 10.1016/0741-8329(95)02013-6
21. PR Sinclair N Gorman T Dalton HS Walton WJ Bement JF Sinclair AG Smith DW Nebert 1998 Uroporphyria produced in mice by iron and 5-aminolevulinic acid does not occur in Cyp1a2(-/-) null mutant mice Biochem J 330 149 153
22. PR Sinclair N Gorman JF Sinclair HS Walton WJ Bement RW Lambrecht 1995 Ascorbic acid inhibits chemically induced uroporphyria in ascorbate-requiring rats Hepatology 22 565 572
23. AG Smith JE Francis 1983 Synergism of iron and hexachlorobenzene inhibits hepatic uroporphyrinogen decarboxylase in inbred mice Biochem J 214 909 913
24. AG Smith JE Francis 1993 Genetic variation of iron-induced uroporphyria in mice Biochem J 291 29 35
25. AG Smith JR Cabral P Carthew JE Francis MM Manson 1989 Carcinogenicity of iron in conjunction with a chlorinated environmental chemical, hexachlorobenzene, in C57BL/10ScSn mice Int J Cancer 43 492 496 10.1002/ijc.2910430325
26. AG Smith B Clothier P Carthew NL Childs PR Sinclair DW Nebert TP Dalton 2001 Protection of the Cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin Toxicol Appl Pharmacol 173 89 98 10.1006/taap.2001.9167
27. AG Smith B Clothier S Robinson MJ Scullion P Carthew R Edwards J Luo CK Lim M Toledano 1998 Interaction between iron metabolism and 2,3,7,8- tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism Mol Pharmacol 53 52 61
28. AG Smith JE Francis 1987 Chemically-induced formation of an inhibitor of hepatic uroporphyrinogen decarboxylase in inbred mice with iron overload Biochem J 246 221 226
29. AG Smith JE Francis JA Green JB Greig CR Wolf MM Manson 1990 Sex-linked hepatic uroporphyria and the induction of cytochromes P450IA in rats caused by hexachlorobenzene and polyhalogenated biphenyls Biochem Pharmacol 40 2059 2068 10.1016/0006-2952(90)90236-E
30. GD Sweeney KG Jones FM Cole D Basford F Krestynski 1979 Iron deficiency prevents liver toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin Science 204 332 335 10.1126/science.432648
31. H Towbin T Staehelin J Gordon 1979 Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications Proc Natl Acad Sci USA 76 4350 4354 10.1073/pnas.76.9.4350