The Neurocognitive Enhancement of Surgeons: An Ethical Perspective

Journal of Surgical Research

Volumn 152, Issue 1, 2009, Pages 167-172

  Warren, Oliver J ^a   Leff, Daniel R ^a   Athanasiou, Thanos ^a   Kennard, Christopher ^a   Darzi, Ara ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

cognition; ethics; psychopharmacology; surgery

Indexed keywords

BROMOCRIPTINE; DEXAMPHETAMINE; DONEPEZIL; METHYLPHENIDATE; MODAFINIL; PSYCHOTROPIC AGENT;

ANXIETY; ARTICLE; ATTENTION DEFICIT DISORDER; COGNITION; DRUG INDUSTRY; DRUG SAFETY; ETHICS; GASTROINTESTINAL SYMPTOM; HUMAN; HYPERTENSION; JOB PERFORMANCE; MEDICAL DECISION MAKING; MEDICAL PRACTICE; MEDICAL SCHOOL; MENTAL PERFORMANCE; PATIENT SAFETY; PRESCRIPTION; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; SIDE EFFECT; SURGEON; TACHYCARDIA;

CHARACTER; COERCION; FREEDOM; HUMANS; INDIVIDUALITY; PERSONHOOD; PHYSICIANS; PSYCHOTROPIC DRUGS; SPECIALTIES, SURGICAL;

EID: 63049119082     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2007.12.761     Document Type: Article

References (49)

1. Rose S.P. 'Smart drugs': do they work?. Are they ethical? Will they be legal?. Nat Rev Neurosci 3 (2002) 975
2. Farah M.J. Emerging ethical issues in neuroscience. Nat Neurosci 5 (2002) 1123
3. Wolpe P.R. Treatment, enhancement, and the ethics of neurotherapeutics. Brain Cogn 50 (2002) 387
4. Liepert J. Transcranial magnetic stimulation in neurorehabilitation. Acta Neurochir Suppl 93 (2005) 71
5. Birbaumer N., and Cohen L.G. Brain-computer interfaces: Communication and restoration of movement in paralysis. J Physiol 579 (2007) 621
6. Koch K.P. Neural prostheses and biomedical microsystems in neurological rehabilitation. Acta Neurochir Suppl 97 (2007) 427
7. Master Z., McLeod M., and Mendez I. Benefits, risks and ethical considerations in translation of stem cell research to clinical applications in Parkinson's disease. J Med Ethics 33 (2007) 169
8. Diller L.H. The run on Ritalin. Attention deficit disorder and stimulant treatment in the 1990s. Hastings Cent Rep 26 (1996) 12
9. Babcock Q., and Byrne T. Student perceptions of methylphenidate abuse at a public liberal arts college. J Am Coll Health 49 (2000) 143
10. Hall S.S. The quest for a smart pill. Sci Am 289 (2003) 54 60
11. Solomon P.R., Adams F., Silver A., et al. Ginkgo for memory enhancement: A randomized controlled trial. JAMA 288 (2002) 835
12. Chatterjee A. Cosmetic neurology: The controversy over enhancing movement, mentation, and mood. Neurology 63 (2004) 968
13. Farah M.J., Illes J., Cook-Deegan R., et al. Neurocognitive enhancement: what can we do and what should we do?. Nat Rev Neurosci 5 (2004) 421
14. Pary R., Lewis S., Matuschka P.R., et al. Attention deficit disorder in adults. Ann Clin Psychiatry 14 (2002) 105
15. Weber P., and Lutschg J. Methylphenidate treatment. Pediatr Neurol 26 (2002) 261
16. Mehta M.A., Owen A.M., Sahakian B.J., et al. Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain. J Neurosci 20 (2000) RC65
17. Luciana M., Depue R.A., Arbisi P., and Leon A. Facilitation of working memory by a D2 receptor agonist in human subjects. J Cogn Neurosci 4 (1992) 58
18. Yesavage J.A., Mumenthaler M.S., Taylor J.L., et al. Donepezil and flight simulator performance: Effects on retention of complex skills. Neurology 59 (2002) 123
19. Jacobs I., and Bell D.G. Effects of acute modafinil ingestion on exercise time to exhaustion. Med Sci Sports Exerc 36 (2004) 1078
20. Caldwell Jr. J.A., Caldwell J.L., Smythe III N.K., et al. A double-blind, placebo-controlled investigation of the efficacy of modafinil for sustaining the alertness and performance of aviators: a helicopter simulator study. Psychopharmacology (Berl) 150 (2000) 272
21. Lagarde D., Batejat D., Van Beers P., et al. Interest of modafinil, a new psychostimulant, during a sixty-hour sleep deprivation experiment. Fundam Clin Pharmacol 9 (1995) 271
22. Caldwell J.A., Caldwell J.L., Smith J.K., et al. Modafinil's effects on simulator performance and mood in pilots during 37 h without sleep. Aviat Space Environ Med 75 (2004) 777
23. Baranski J.V., and Pigeau R.A. Self-monitoring cognitive performance during sleep deprivation: Effects of modafinil, d-amphetamine and placebo. J Sleep Res 6 (1997) 84
24. Wesensten N.J., Belenky G., Kautz M.A., et al. Maintaining alertness and performance during sleep deprivation: Modafinil versus caffeine. Psychopharmacology (Berl) 159 (2002) 238
25. Buguet A., Montmayeur A., Pigeau R., et al. Modafinil, d-amphetamine and placebo during 64 hours of sustained mental work. II. Effects on two nights of recovery sleep. J Sleep Res 4 (1995) 229
26. Randall D.C., Shneerson J.M., Plaha K.K., et al. Modafinil affects mood, but not cognitive function, in healthy young volunteers. Hum Psychopharmacol 18 (2003) 163
27. Randall D.C., Viswanath A., Bharania P., et al. Does modafinil enhance cognitive performance in young volunteers who are not sleep-deprived?. J Clin Psychopharmacol 25 (2005) 175
28. Randall D.C., Shneerson J.M., and File S.E. Cognitive effects of modafinil in student volunteers may depend on IQ. Pharmacol Biochem Behav 82 (2005) 133
29. Directive 93/104/EC concerning certain aspects of the organization of working time. The Council of the European Union (1993). http://eur-lex.europa.eu Accessed: October 22, 2007
30. Patient and Physician Safety and Protection Act of 2001, 107th Congress (2001). http://thomas.loc.gov/ Accessed: October 22, 2007
31. Taffinder N.J., McManus I.C., Gul Y., et al. Effect of sleep deprivation on surgeons' dexterity on laparoscopy simulator. Lancet 352 (1998) 1191
32. Marcus C.L., and Loughlin G.M. Effect of sleep deprivation on driving safety in housestaff. Sleep 19 (1996) 763
33. Steele M.T., Ma O.J., Watson W.A., et al. The occupational risk of motor vehicle collisions for emergency medicine residents. Acad Emerg Med 6 (1999) 1050
34. Humayun M.U., Rader R.S., Pieramici D.J., et al. Quantitative measurement of the effects of caffeine and propranolol on surgeon hand tremor. Arch Ophthalmol 115 (1997) 371
35. Gill M., Haerich P., Westcott K., et al. Cognitive performance following modafinil versus placebo in sleep-deprived emergency physicians: A double-blind randomized crossover study. Acad Emerg Med 13 (2006) 158
36. Duteil J., Rambert F.A., Pessonnier J., et al. Central alpha 1-adrenergic stimulation in relation to the behaviour stimulating effect of modafinil; studies with experimental animals. Eur J Pharmacol 180 (1990) 49
37. Simon P., Hemet C., Ramassamy C., et al. Non-amphetaminic mechanism of stimulant locomotor effect of modafinil in mice. Eur Neuropsychopharmacol 5 (1995) 509
38. Edgar D.M., and Seidel W.F. Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat. J Pharmacol Exp Ther 283 (1997) 757
39. US Modafinil in Narcolepsy Multicenter Study Group. Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy. Ann Neurol 43 (1998) 88
40. Kollins S.H., MacDonald E.K., and Rush C.R. Assessing the abuse potential of methylphenidate in nonhuman and human subjects: A review. Pharmacol Biochem Behav 68 (2001) 611
41. Jasinski D.R., and Kovacevic-Ristanovic R. Evaluation of the abuse liability of modafinil and other drugs for excessive daytime sleepiness associated with narcolepsy. Clin Neuropharmacol 23 (2000) 149
42. Jasinski D.R. An evaluation of the abuse potential of modafinil using methylphenidate as a reference. J Psychopharmacol 14 (2000) 53
43. Srisurapanont M., Jarusuraisin N., and Kittirattanapaiboon P. Treatment for amphetamine withdrawal. Cochrane Database Syst Rev 4 (2001) CD003021
44. Kass L.R. Equality reconsidered-human frailty and human dignity. The embryo question III. New Atlantis 7 (2004) 110
45. Elliott C. American bioscience meets the American dream. Am Prospect 14 (2003) 38
46. Thursky K.A., and Mahemoff M. User-centered design techniques for a computerised antibiotic decision support system in an intensive care unit. Int J Med Inform 76 (2006) 760
47. Philip P., Taillard J., Moore N., et al. The effects of coffee and napping on nighttime highway driving: A randomized trial. Ann Intern Med 144 (2006) 785
48. Arora V., Dunphy C., Chang V.Y., et al. The effects of on-duty napping on intern sleep time and fatigue. Ann Intern Med 144 (2006) 792
49. Iredale W. Tired professors take 'smart' pills to perk up lectures (July 15, 2007), The Sunday Times, London