Influence of testosterone and a novel SARM on gene expression in whole blood of Macaca fascicularis

Journal of Steroid Biochemistry and Molecular Biology

Volumn 114, Issue 3-5, 2009, Pages 167-173

  Riedmaier, Irmgard ^a   Tichopad, Ales ^a   Reiter, Martina ^a   Pfaffl, Michael W ^a   Meyer, Heinrich H D ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Biomarker; Gene expression; Real time qRT PCR; SARM; Testosterone

Indexed keywords

LGD 2941; MESSENGER RNA; SELECTIVE ANDROGEN RECEPTOR MODULATOR; TESTOSTERONE ENANTATE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG EFFECT; GEL ELECTROPHORESIS; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; MACACA; MALE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; INTERLEUKINS; MACACA FASCICULARIS; PYRROLIDINES; QUINOLONES; RNA, MESSENGER; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TESTOSTERONE;

MACACA FASCICULARIS;

EID: 63049113625     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2009.01.019     Document Type: Article

References (34)

1. Walsh M.C., Hunter G.R., and Livingstone M.B. Sarcopenia in premenopausal and postmenopausal women with osteopenia, osteoporosis and normal bone mineral density. Osteoporos. Int. 17 1 (2006) 61-67
2. Morley J.E., Baumgartner R.N., Roubenoff R., Mayer J., and Nair K.S. Sarcopenia. J. Lab. Clin. Med. 137 4 (2001) 231-243
3. Morley J.E. Anorexia, sarcopenia, and aging. Nutrition 17 7-8 (2001) 660-663
4. Morley J.E., Kim M.J., and Haren M.T. Frailty and hormones. Rev. Endocr. Metab. Disord. 6 2 (2005) 101-108
5. Marcell T.J. Sarcopenia: causes, consequences, and preventions. J. Gerontol. A Biol. Sci. Med. Sci. 58 10 (2003) M911-M916
6. Negro-Vilar A. Selective androgen receptor modulators (SARMs): a novel approach to androgen therapy for the new millennium. J. Clin. Endocrinol. Metab. 84 10 (1999) 3459-3462
7. Martinborough E., Shen Y., Oeveren A., Long Y.O., Lau T.L., Marschke K.B., Chang W.Y., Lopez F.J., Vajda E.G., Rix P.J., Viveros O.H., Negro-Vilar A., and Zhi L. Substituted 6-(1-pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators. J. Med. Chem. 50 21 (2007) 5049-5052
8. Deschenes M.R. Effects of aging on muscle fibre type and size. Sports Med. 34 12 (2004) 809-824
9. Doherty T.J. Invited review: aging and sarcopenia. J. Appl. Physiol. 95 4 (2003) 1717-1727
10. Lopez F.J. New approaches to the treatment of osteoporosis. Curr. Opin. Chem. Biol. 4 4 (2000) 383-393
11. Fleige S., and Pfaffl M.W. RNA integrity and the effect on the real-time qRT-PCR performance. Mol. Aspects Med. 27 2-3 (2006) 126-139
12. Schroeder A., Mueller O., Stocker S., Salowsky R., Leiber M., Gassmann M., Lightfoot S., Menzel W., Granzow M., and Ragg T. The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol. Biol. 7 (2006) 3-17
13. Lehmann D., Siebold K., Emmons L.R., and Muller H. Androgens inhibit proliferation of human peripheral blood lymphocytes in vitro. Clin. Immunol. Immunopathol. 46 1 (1988) 122-128
14. Jacobson J.D., and Ansari M.A. Immunomodulatory actions of gonadal steroids may be mediated by gonadotropin-releasing hormone. Endocrinology 145 1 (2004) 330-336
15. Huber S.A., Kupperman J., and Newell M.K. Estradiol prevents and testosterone promotes Fas-dependent apoptosis in CD4+ Th2 cells by altering Bcl 2 expression. Lupus 8 5 (1999) 384-387
16. McMurray R.W., Suwannaroj S., Ndebele K., and Jenkins J.K. Differential effects of sex steroids on T and B cells: modulation of cell cycle phase distribution, apoptosis and bcl-2 protein levels. Pathobiology 69 1 (2001) 44-58
17. Cutolo M., Capellino S., Montagna P., Ghiorzo P., Sulli A., and Villaggio B. Sex hormone modulation of cell growth and apoptosis of the human monocytic/macrophage cell line. Arthritis Res. Ther. 7 5 (2005) R1124-R1132
18. Nagata S. Apoptosis by death factor. Cell 88 3 (1997) 355-365
19. Rothstein T.L., Wang J.K.M., Panka D.J., Foote L.C., Wang Z.H., Stanger B., Cui H., Ju S.T., and Marshakrothstein A. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B-cells. Nature 374 6518 (1995) 163-165
20. Krammer P.H. CD95's deadly mission in the immune system. Nature 407 6805 (2000) 789-795
21. Klas C., Debatin K.M., Jonker R.R., and Krammer P.H. Activation interferes with the Apo-1 pathway in mature human T-cells. Int. Immunol. 5 6 (1993) 625-630
22. Leithauser F., Dhein J., Mechtersheimer G., Koretz K., Bruderlein S., Henne C., Schmidt A., Debatin K.M., Krammer P.H., and Moller P. Constitutive and induced expression of Apo-1, a new member of the nerve growth-factor tumor-necrosis-factor receptor superfamily, in normal and neoplastic-cells. Lab. Invest. 69 4 (1993) 415-429
23. Chan H., Bartos D.P., and Owen-Schaub L.B. Activation-dependent transcriptional regulation of the human fas promoter requires NF-kappa B p50-p65 recruitment. Mol. Cell. Biol. 19 3 (1999) 2098-2108
24. Vandenabeele P., Declercq W., Beyaert R., and Fiers W. Two tumour necrosis factor receptors: structure and function. Trends Cell Biol. 5 10 (1995) 392-399
25. Kadin M.E. Regulation of CD30 antigen expression and its potential significance for human disease. Am. J. Pathol. 156 5 (2000) 1479-1484
26. Romagnani P., Annunziato F., Manetti R., Mavilia C., Lasagni L., Manuelli C., Vannelli G.B., Vanini V., Maggi E., Pupilli C., and Romagnani S. High CD30 ligand expression by epithelial cells and Hassal's corpuscles in the medulla of human thymus. Blood 91 9 (1998) 3323-3332
27. Grossman C. Possible underlying mechanisms of sexual dimorphism in the immune response, fact and hypothesis. J. Steroid Biochem. 34 1-6 (1989) 241-251
28. Morell V. Zeroing in on how hormones affect the immune system. Science 269 5225 (1995) 773-775
29. Verthelyi D. Sex hormones as immunomodulators in health and disease. Int. Immunopharmacol. 1 6 (2001) 983-993
30. Del Vecchio M., Bajetta E., Canova S., Lotze M.T., Wesa A., Parmiani G., and Anichini A. Interleukin-12: biological properties and clinical application. Clin. Cancer Res. 13 16 (2007) 4677-4685
31. Liu K., Catalfamo M., Li Y., Henkart P.A., and Weng N.P. IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells. Proc. Natl. Acad. Sci. U.S.A. 99 9 (2002) 6192-6197
32. Liu Z., Geboes K., Colpaert S., D'Haens G.R., Rutgeerts P., and Ceuppens J.L. IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production. J. Immunol. 164 7 (2000) 3608-3615
33. Carson W.E., Ross M.E., Baiocchi R.A., Marien M.J., Boiani N., Grabstein K., and Caligiuri M.A. Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro. J. Clin. Invest. 96 6 (1995) 2578-2582
34. Carson W.E., Giri J.G., Lindemann M.J., Linett M.L., Ahdieh M., Paxton R., Anderson D., Eisenmann J., Grabstein K., and Caligiuri M.A. Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J. Exp. Med. 180 4 (1994) 1395-1403