Synthesis and biological evaluation of N4-(hetero)arylsulfonylquinoxalinones as HIV-1 reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 7, 2009, Pages 2767-2774

  Xu, Bailing ^a   Sun, Yan ^a   Guo, Ying ^a   Cao, Yingli ^a   Yu, Tao ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

HIV 1 Reverse transcriptase inhibitor; Quinoxalinone; Structure activity relationship

Indexed keywords

6 CHLORO 3 ETHYL 4 (2 METHYOXYCARBONYLTHIOPHENE 3 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; 6 CHLORO 3 ETHYL 4 (QUINOLINE 8 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; 6 CHLORO 3 METHYL 4 (2 METHYOXYCARBONYLTHIOPHENE 3 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; 6 CHLORO 3 METHYL 4 (QUINOLINE 8 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; 6 CHLORO 4 (2 METHOXYCARBONYLTHIOPHENE 3 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; 6 CHLORO 4 (QUINOLINE 8 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; 6 FLUORO 3 [(2 METHOXYCARBONYL)METHYL] 4 (2 METHYOXYCARBONYLTHIOPHENE 3 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; 6 FLUORO 3 [(2 METHYLTHIO)ETHYL] 4 (2 METHYOXYCARBONYLTHIOPHENE 3 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; 6 FLUORO 3 ETHYL 4 (2 METHYOXYCARBONYLTHIOPHENE 3 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; 6 FLUORO 3 METHYL 4 (2 METHYOXYCARBONYLTHIOPHENE 3 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; 6 FLUORO 3 METHYL 4 (2,5 DICHLOROTHIOPHENE 3 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; 6 FLUORO 3 METHYL 4 (3 CYANOBENZENE 1 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; 6 FLUORO 3 METHYL 4 (4 NITROBENZENE 1 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; 6 FLUORO 3 METHYL 4 (QUINOLINE 8 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; 6 FLUORO 4 (2 METHYOXYCARBONYLTHIOPHENE 3 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; 6 FLUORO 4 (3 CYANOBENZENE 1 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; 6 FLUORO 4 (QUINOLINE 8 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; 7 TRIFLUOROMETHYL 4 (2 METHYOXYCARBONYLTHIOPHENE 3 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; 7 TRIFLUOROMETHYL 4 (QUINOLINE 8 SULFONYL) 3,4 DIHYDROQUINOXALIN 2(1H) ONE; QUINOXALINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

ANTI-HIV AGENTS; HIV REVERSE TRANSCRIPTASE; QUINOXALINES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 62949241322     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.02.039     Document Type: Article

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