Effects of zidovudine and stavudine on mitochondrial DNA of differentiating 3T3-F442a cells are not associated with imbalanced deoxynucleotide pools

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 3, 2009, Pages 1252-1255

  Lynx, Matthew D ^a,b   Laclair, Darcy D ^a,b   McKee, Edward E ^a,b  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEOTIDE; MITOCHONDRIAL DNA; STAVUDINE; THYMIDINE; THYMIDINE TRIPHOSPHATE; ZIDOVUDINE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONTROLLED STUDY; CYTOTOXICITY; DNA CONTENT; DRUG EFFECT; MITOCHONDRIAL DNA DEPLETION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

3T3 CELLS; ANIMALS; ANTI-HIV AGENTS; CELL DIFFERENTIATION; DEOXYRIBONUCLEOTIDES; DNA, MITOCHONDRIAL; DOSE-RESPONSE RELATIONSHIP, DRUG; KINETICS; MICE; STAVUDINE; ZIDOVUDINE;

EID: 62949203113     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01115-08     Document Type: Article

References (24)

1. Ashley, N., S. Adams, A. Slama, M. Zeviani, A. Suomalainen, A. L. Andreu, R. K. Naviaux, and J. Poulton. 2007. Defects in maintenance of mitochon-drial DNA are associated with intramitochondrial nucleotide imbalances. Hum. Mol. Genet. 16:1400-1411.
2. Bourdon, A., L. Minai, V. Serre, J. P. Jais, E. Sarzi, S. Aubert, D. Chretien, P. de Lonlay, V. Paquis-Flucklinger, H. Arakawa, Y. Nakamura, A, Mun-nich, and A. Rotig. 2007. Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. Nat. Genet. 39:776-780.
3. Deveaud, C, B. Beauvoit, S. Hagry, A. Galinier, A. Carriere, B. Salin, J. Schaeffer, S- Caspar-Bauguil, Y. Fernandez, J. B. Gordien, D. Breilh, L. Penicaud, L. Casteilla, and M, Rigoulet. 2005. Site specific alterations of adipose tissue mitochondria in 3′-azido-3′-deoxythymidine (AZT)-treated rats: an early stage in lipodystrophy? Biochem. Pharmacol. 70:90-101.
4. Fridland, A., M. C. Connelly, and R. Ashmun. 1990. Relationship of deoxynucleotide changes to inhibition of DNA synthesis induced by the antiretroviral agent 3′-azido-3′-deoxythymidine and release of its monophosphate by human lymphoid cells (CCRF-CEM). Mol. Pharmacol. 37:665-670.
5. Hakansson, P., A. Hofer, and L. Thelander. 2006. Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells. J. Biol. Chem. 281:7834-7841.
6. Lavie, A., I. R. Vetter, M. Konrad, R. S. Goody, J. Reinstein, and I. Schlichting. 1997. Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation. Nat. Struct. Biol. 4:601-604.
7. Lewis, W., and M. C. Dalakas. 1995. Mitochondrial toxicity of antiviral drugs. Nat. Med. 1:417-422.
8. Lund, K. C., L. L. Peterson, and K. B. Wallace. 2007. Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs. Antimicrob. Agents Chemother. 51:2531-2539.
9. Lynx, M. D., A. T. Bentley, and E. E. McKee. 2006. 3′-Azido-3′-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity. Biochem. Pharmacol. 71:1342-1348.
10. Lynx, M. D., and E. E. McKee. 2006. 3′-Azido-3′- deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria. Biochem. Pharmacol. 72:239-243.
11. Martin, J. L., C. E. Brown, N. Matthews-Davis, and J. E. Reardon. 1994. Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis. Antimicrob. Agents Chemother. 38:2743-2749.
12. McKee, E. E., A. T. Bentley, M. Hatch, J. Gingerich, and D. Susan-Resiga. 2004. Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity. Cardiovasc. Toxicol. 4:155-167.
13. Moyle, G. 2000. Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity. Clin. Ther. 22:911-936.
14. Munch-Petersen, B., L. Cloos, G. Tyrsted, and S. Eriksson. 1991. Diverging substrate specificity of pure human thymidine kinases 1 and 2 against anti viral dideoxynucleosides. J. Biol. Chem. 266:9032-9038.
15. Pontarin, G., P. Ferraro, P. Hakansson, L. Thelander, P. Reichard, and V. Bianchi. 2007. p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage. J. Biol. Chem. 282:16820-16828.
16. Pontarin, G., P. Ferraro, M. L. Valentino, M. Hirano, P. Reichard, and V. Bianchi. 2006. Mitochondrial DNA depletion and thymidine phosphate pool dynamics in a cellular model of mitochondrial neurogastrointestinal encephalomyopathy. J. Biol. Chem. 281:22720-22728.
17. Sherman, P. A., and J. A. Fyfe. 1989. Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers. Anal. Biochem. 180:222-226.
18. Song, S., Z. F. Pursell, W. C. Copeland, M. J. Longley, T. A. Kunkel, and C. K. Mathews. 2005. DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity. Proc. Natl. Acad. Sci. USA 102:4990-4995.
19. Song, S., L. J. Wheeler, and C. K. Mathews. 2003. Deoxyribonucleotide pool imbalance stimulates deletions in HeLa cell mitochondrial DNA J. Biol. Chem. 278:43893-43896.
20. Stankov, M. V., R. E. Schmidt, and G. M. Behrens. 2008. Zidovudine impairs adipogenic differentiation through inhibition of clonal expansion. Antimicrob. Agents Chemother. 52:2882-2889.
21. Susan-Resiga, D., A. T. Bentley, M. D. Lynx, D. D. LaClair, and E. E. McKee. 2007. Zidovudine inhibits thymidine phosphorylation in the isolated perfused rat heart. Antimicrob. Agents Chemother. 51:1142-1149.
22. Tozser, J. 2001. HIV inhibitors: problems and reality. Ann. N. Y. Acad. Sci. 946:145-159.
23. Vela, J. E., M. D. Miller, G. R. Rhodes, and A. S. Ray. 2008. Effect of nucleoside and nucleotide reverse transcriptase inhibitors of HIV on endogenous nucleotide pools. Antivir. Ther. 13:789-797.
24. Walker, U. A., M. Auclair, D. Lebrecht, M. Kornprobst, J. Capeau, and M. Caron. 2006. Undine abrogates the adverse effects of antiretroviral pyrimidine analogues on adipose cell functions. Antivir. Ther. 11:25-34.