Methionine Synthase Reductase (MTRR) A66G polymorphism is not related to plasma homocysteine concentration and the risk for vascular disease

Experimental and Molecular Pathology

Volumn 86, Issue 2, 2009, Pages 131-133

  Scazzone, C ^a   Acuto, S ^b   Guglielmini, E ^a   Campisi, G ^a   Bono, A ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b Unita di Ricerca P Cutino   (Italy)

Author keywords

Arterial thrombosis; Deep vein thrombosis; Homocysteine; Methionine Synthase Reductase; Polymorphism

Indexed keywords

HOMOCYSTEINE; METHIONINE SYNTHASE REDUCTASE;

ADULT; AGED; ARTERY THROMBOSIS; ARTICLE; BLOOD SAMPLING; CARDIOVASCULAR RISK; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; VASCULAR DISEASE;

ADULT; AGED; CASE-CONTROL STUDIES; FEMALE; FERREDOXIN-NADP REDUCTASE; GENETIC PREDISPOSITION TO DISEASE; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; VASCULAR DISEASES;

EID: 62949173761     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2009.01.014     Document Type: Article

References (20)

1. Bosco P., Guéant-Rodriguez R.M., Anello G., Barone C., Namour F., Caraci F., Romano A., Romano C., and Guéant J.L. Methionine synthase (MTR) 2756 (A→G) polymorphism, double heterozygosity methionine synthase 2756 AG/Methionine Synthase Reductase (MTRR) 66 AG, and elevated homocysteinemia are three risk factors for having a child with Down syndrome. Am. J. Med. Genet. A 121A 3 (2003) 219-224
2. Bosco P., Guéant-Rodriguez R.M., Anello G., Spada R., Romano A., Fajardo A., Caraci F., Ferri R., and Guéant J.L. Association of homocysteine (but not of MTHFR 677 C>T, MTR 2756 A>G, MTRR 66 A>G and TCN2 776 C>G) with ischaemic cerebrovascular disease in Sicily. Thromb. Haemost. 96 2 (2006) 154-159
3. Brilakis E.S., Berger P.B., Ballman K.V., and Rozen R. Methylenetetrahydrofolate Reductase (MTHFR) 677C>T and Methionine Synthase Reductase (MTRR) 66A>G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid. Atherosclerosis 168 2 (2003) 315-322
4. den Heijer M., Koster T., Blom H.J., Bos G.M., Briet E., Reitsma P.H., Vandenbroucke J.P., and Rosendaal F.R. Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N. Engl. J. Med. 21 12 (1996) 759-762 334
5. Domagala T.B., Adamek L., Nizankowska E., Sanak M., and Szczeklik A. Mutations C677T and A1298C of the 5,10-methylenetetrahydrofolate reductase gene and fasting plasma homocysteine levels are not associated with the increased risk of venous thromboembolic disease. Blood Coagul. Fibrinolysis 13 5 (2002) 423-431
6. Engbersen A.M., Franken D.G., Boers G.H., Stevens E.M., Trijbels F.J., and Blom H.J. Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia. Am. J. Hum. Genet. 56 1 (1995) 142-150
7. Frederiksen J., Juul K., Grande P., Jensen G.B., Schroeder T.V., Tybjaerg-Hansen A., and Nordestgaard B.G. Methylenetetrahydrofolate Reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism: prospective and case-control studies from the Copenhagen City Heart Study. Blood 104 10 (2004) 3046-3051
8. Frosst P., Blom H.J., Milos R., Goyette P., Sheppard C.A., Matthews R.G., Boers G.J., den Heijer M., Kluijtmans L.A., and van den Heuvel L.P. A candidate genetic risk factor for vascular disease: a common mutation in Methylenetetrahydrofolate Reductase. Nat. Genet. 10 1 (1995) 111-113
9. Gaughan D.J., Kluijtmans L.A., Barbaux S., McMaster D., Young I.S., Yarnell J.W., Evans A., and Whitehead A.S. The Methionine Synthase Reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations. Atherosclerosis 157 2 (2001) 451-456
10. Gemmati D., Serino M.L., Trivellato C., Fiorini S., and Scapoli G.L. C677T substitution in the Methylenetetrahydrofolate Reductase gene as a risk factor for venous thrombosis and arterial disease in selected patients. Haematologica 84 9 (1999) 824-828
11. Guéant-Rodriguez R.M., Juilliérem Y., Candito M., Adjalla C.E., Gibelin P., Herbeth B., Van Obberghen E., and Gueánt J.L. Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population. Thromb. Haemost. 94 3 (2005) 510-515
12. Jacques P.F., Bostom A.G., Selhub J., Rich S., Ellison R.C., Eckfeldt J.H., Gravel R.A., and Rozen R. Effects of polymorphisms of methionine synthase and Methionine Synthase Reductase on total plasma homocysteine in the NHLBI Family Heart Study. Atherosclerosis 166 1 (2003) 49-55
13. Kluijtmans L.A., Young I.S., Boreham C.A., Murray L., McMaster D., McNulty H., Strain J.J., McPartlin J., Scott J.M., and Whitehead A.S. Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood 101 7 (2003) 2483-2488
14. Laraqui A., Allami A., Carrié A., Coiffard A.S., Benkouka F., Benjouad A., Bendriss A., Kadiri N., Bennouar N., Benomar A., Guedira A., Raisonnier A., Fellati S., Srairi J.E., and Benomar M. Influence of methionine synthase (A2756G) and Methionine Synthase Reductase (A66G) polymorphisms on plasma homocysteine levels and relation to risk of coronary artery disease. Acta Cardiol. 61 1 (2006) 51-61
15. Rees M.M., and Rodgers G.M. Homocysteinemia: association of a metabolic disorder with vascular disease and thrombosis. Thromb. Res. 71 5 (1993) 337-359
16. Refsum H., Ueland P.M., Nygard O., and Vollset S.E. Homocysteine and cardiovascular disease. Annu. Rev. Med. 49 (1998) 31-62
17. Szvetko A.L., Fowdar J., Nelson J., Colson N., Tajouri L., Csurhes P.A., Pender M.P., and Griffiths L.R. No association between MTHFR A1298C and MTRR A66G polymorphisms, and MS in an Australian cohort. J. Neurol. Sci. 252 1 (2006) 49-52
18. Townend J., O'Sullivan J., and Wilde J.T. Hyperhomocysteinaemia and vascular disease. Blood Rev. 12 1 (1998) 23-34
19. Verhoef P., Kok F.J., Kluijtmans L.A., Blom H.J., Refsum H., and Ueland P.M. The 677C→T mutation in the methylenetetrahydrofolate reductase gene: associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease. Atherosclerosis 132 (1997) 105-113
20. Wilson R.P., Leclerc D., Christensen B., Yang H., Gravel R.A., and Rozen R. A common variant in Methionine Synthase Reductase combined with low cobalamin (Vitamin B12) increases risk for spina bifida. Mol. Genet. Metab. 67 (1999) 317-323