Selectivity profiling of DegP substrates and inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 7, 2009, Pages 2920-2924

  Hauske, Patrick ^a,b   Meltzer, Michael ^b   Ottmann, Christian ^a   Krojer, Tobias ^c   Clausen, Tim ^c   Ehrmann, Michael ^b,d   Kaiser, Markus ^a  

^a CHEMICAL GENOMICS CENTRE OF THE MAX PLANCK SOCIETY   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^d CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Allosteric regulation; DegP; HtrA protease; Inhibitor; Substrate

Indexed keywords

4 NITROANILINE; CHLOROMETHYL KETONE; ELASTASE; ELASTASE INHIBITOR; KETONE DERIVATIVE; SERINE PROTEINASE; SERINE PROTEINASE DEGP; SERINE PROTEINASE DEGP INHIBITOR; SERINE PROTEINASE INHIBITOR; SUBTILISIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CLEAVAGE;

AMINO ACID CHLOROMETHYL KETONES; AMINO ACID SEQUENCE; ANILINE COMPOUNDS; HEAT-SHOCK PROTEINS; PEPTIDES; PERIPLASMIC PROTEINS; PROTEASE INHIBITORS; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); PROKARYOTA;

EID: 62949162588     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.01.073     Document Type: Article

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