A new model of outbred genetically selected mice which present a strong acute inflammatory response in the absence of complement component C5

Inflammation Research

Volumn 58, Issue 4, 2009, Pages 204-209

  Amano, M T ^a   Carneiro, A S ^b   Ribeiro, O G ^b   Cabrera, W K ^b   De Franco, M ^b   Ibanez O M ^b   Isaac, L ^a   Starobinas, N ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b INSTITUTO BUTANTAN   (Brazil)

Author keywords

C5 deficiency; Complement System; Inflammation; Innate response; Slc11a1

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; COMPLEMENT COMPONENT C5; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1;

A J MOUSE; ALLELE; ANIMAL MODEL; ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; DNA SEQUENCE; EXPERIMENTAL MODEL; FEMALE; GENE; GENE MUTATION; GENETIC RESISTANCE; GENETIC SUSCEPTIBILITY; HEMOLYSIS; HOMOZYGOTE; IMMUNODIFFUSION; INFLAMMATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OUTBRED STRAIN; PHENOTYPE; POLYMERASE CHAIN REACTION; SERUM;

ANIMALS; CATION TRANSPORT PROTEINS; COMPLEMENT ACTIVATION; COMPLEMENT C5; COMPLEMENT PATHWAY, ALTERNATIVE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HEMOLYSIS; INFLAMMATION; MALE; MICE; MICE, INBRED STRAINS;

EID: 62949159616     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-008-8132-4     Document Type: Article

References (31)

1. Ibanez OM, Stiffel C, Ribeiro OG, Cabrera WK, Massa S, de Franco M, et al. Genetics of nonspecific immunity: I. Bidirectional selective breeding of lines of mice endowed with maximal or minimal inflammatory responsiveness. Eur J Immunol 1992; 22: 2555-63.
2. Biozzi G, Ribeiro OG, Saran A, Araujo ML, Maria DA, De Franco M, et al. Effect of genetic modification of acute inflammatory responsiveness on tumorigenesis in the mouse. Carcinogenesis 1998; 19: 337-46.
3. Vigar ND, Cabrera WH, Araujo LM, Ribeiro OG, Ogata TR, Siqueira M, et al. Pristane-induced arthritis in mice selected for maximal or minimal acute inflammatory reaction. Eur J Immunol 2000; 30: 431-7.
4. Araujo LM, Ribeiro OG, Siqueira M, De Franco M, Starobinas N, Massa S, et al. Innate resistance to infection by intracellular bacterial pathogens differs in mice selected for maximal or minimal acute inflammatory response. Eur J Immunol 1998; 28: 2913-20.
5. Vidal SM, Malo D, Vogan K, Skamene E, Gros P. Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell 1993; 73: 469-85.
6. Hackam DJ, Rotstein OD, Zhang W, Gruenheid S, Gros P, Grinstein S. Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification. J Exp Med 1998; 188: 351-64.
7. Barton CH, Whitehead SH, Blackwell JM. Nramp transfection transfers Ity/Lsh/Bcg-related pleiotropic effects on macrophage activation: influence on oxidative burst and nitric oxide pathways. Mol Med 1995; 1: 267-79.
8. Kita E, Emoto M, Oku D, Nishikawa F, Hamuro A, Kamikaidou N, et al. Contribution of interferon gamma and membrane-associated interleukin 1 to the resistance to murine typhoid of Ityr mice. J Leukoc Biol 1992; 51: 244-50.
9. Wojciechowski W, DeSanctis J, Skamene E, Radzioch D. Attenuation of MHC class II expression in macrophages infected with Mycobacterium bovis bacillus Calmette-Guerin involves class II transactivator and depends on the Nramp1 gene. J Immunol 1999; 163: 2688-96.
10. Borrego A, Peters LC, Jensen JR, Ribeiro OG, Koury Cabrera WH, Starobinas N, et al. Genetic determinants of acute inflammation regulate Salmonella infection and modulate Slc11a1 gene (formerly Nramp1) effects in selected mouse lines. Microbes Infect 2006; 8: 2766-71.
11. D'Eustachio P, Kristensen T, Wetsel RA, Riblet R, Taylor BA, Tack BF. Chromosomal location of the genes encoding complement components C5 and factor H in the mouse. J Immunol 1986; 137: 3990-5.
12. Mastellos D, Papadimitriou JC, Franchini S, Tsonis PA, Lambris JD. A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration. J Immunol 2001; 166: 2479-86.
13. Gerard C, Gerard NP. C5A anaphylatoxin and its seven transmembrane- segment receptor. Annu Rev Immunol 1994; 12: 775-808.
14. Mollnes TE, Brekke OL, Fung M, Fure H, Christiansen D, Bergseth G, et al. Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation. Blood 2002; 100: 1869-77.
15. Strey CW, Markiewski M, Mastellos D, Tudoran R, Spruce LA, Greenbaum LE, et al. The proinflammatory mediators C3a and C5a are essential for liver regeneration. J Exp Med 2003; 198: 913-23.
16. Walport MJ. Complement. Second of two parts. N Engl J Med 2001; 344: 1140-4.
17. Servais G, Walmagh J, Duchateau J. Simple quantitative haemolytic microassay for determination of complement alternative pathway activation (AP50). J Immunol Methods 1991; 140: 93-100.
18. Mardiney MR, Jr., Mueller-Eberhard HJ. Mouse Beta-1c-Globulin: Production of Antiserum and Characterization in the Complement Reaction. J Immunol 1965; 94: 877-82.
19. Ouchterlony Ö. Immunodiffusion and immunoelectrophoresis. In: Weir DM, editor. Handbook of Experimental Immunology. Oxford and Endinburgh: Blackwell, 1967: 655-706.
20. Karp CL, Grupe A, Schadt E, Ewart SL, Keane-Moore M, Cuomo PJ, et al. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Nat Immunol 2000; 1: 221-6.
21. Wetsel RA, Fleischer DT, Haviland DL. Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5'-exon. J Biol Chem 1990; 265: 2435-40.
22. Ribeiro OG, Maria DA, Adriouch S, Pechberty S, Cabrera WH, Morisset J, et al. Convergent alteration of granulopoiesis, chemotactic activity, and neutrophil apoptosis during mouse selection for high acute inflammatory response. J Leukoc Biol 2003; 74: 497-506.
23. Hugli TE. Biochemistry and biology of anaphylatoxins. Complement 1986; 3: 111-27.
24. Aksamit RR, Falk W, Leonard EJ. Chemotaxis by mouse macrophage cell lines. J Immunol 1981; 126: 2194-9.
25. Blackwell JM, Searle S, Goswami T, Miller EN. Understanding the multiple functions of Nramp1. Microbes Infect 2000; 2: 317-21.
26. Haviland DL, Haviland JC, Fleischer DT, Wetsel RA. Structure of the murine fifth complement component (C5) gene. A large, highly interrupted gene with a variant donor splice site and organizational homology with the third and fourth complement component genes. J Biol Chem 1991; 266: 11818-25.
27. De Franco M, Carneiro Pdos S, Peters LC, Vorraro F, Borrego A, Ribeiro OG, et al. Slc11a1 (Nramp1) alleles interact with acute inflammation loci to modulate wound-healing traits in mice. Mamm Genome 2007; 18: 263-9.
28. Grant EP, Picarella D, Burwell T, Delaney T, Croci A, Avitahl N, et al. Essential role for the C5a receptor in regulating the effector phase of synovial infiltration and joint destruction in experimental arthritis. J Exp Med 2002; 196: 1461-71.
29. Hietala MA, Nandakumar KS, Persson L, Fahlen S, Holmdahl R, Pekna M. Complement activation by both classical and alternative pathways is critical for the effector phase of arthritis. Eur J Immunol 2004; 34: 1208-16.
30. Peters LC, Jensen JR, Borrego A, Cabrera WH, Baker N, Starobinas N, et al. Slc11a1 (formerly NRAMP1) gene modulates both acute inflammatory reactions and pristane-induced arthritis in mice. Genes Immun 2007; 8: 51-6.
31. Pickering MC, Warren J, Rose KL, Carlucci F, Wang Y, Walport MJ, et al. Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice. Proc Natl Acad Sci U S A 2006; 103: 9649-54.