Estimating the operating point of the cochlear transducer using low-frequency biased distortion products

Journal of the Acoustical Society of America

Volumn 125, Issue 4, 2009, Pages 2129-2145

  Brown, Daniel J ^a   Hartsock, Jared J ^a   Gill, Ruth M ^a   Fitzgerald, Hillary E ^a   Salt, Alec N ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOLTZMANN; BOLTZMANN DISTRIBUTIONS; COCHLEAR TRANSDUCERS; COMPUTER MODELS; DIAGNOSTIC TOOLS; DISTORTION PRODUCT OTOACOUSTIC EMISSIONS; DISTORTION PRODUCTS; EAR CANALS; ELECTRICAL RESPONSE; FIRST ORDERS; LOW FREQUENCIES; NONLINEAR TRANSDUCTIONS; OPERATING POINTS; ORGAN OF CORTI; RELATIVE AMPLITUDES; SOUND PRESSURE LEVELS;

ACOUSTIC EMISSIONS; ACOUSTICS; BIOLOGICAL MATERIALS; BOLTZMANN EQUATION; PIEZOELECTRIC TRANSDUCERS;

AUDIO FREQUENCY AMPLIFIERS;

ANIMAL EXPERIMENT; ARTICLE; AUDITORY STIMULATION; COCHLEA POTENTIAL; COMPUTER MODEL; CONTROLLED STUDY; DISTORTION PRODUCT OTOACOUSTIC EMISSION; GUINEA PIG; NONHUMAN; OTOACOUSTIC EMISSION; PRIORITY JOURNAL; SOUND INTENSITY;

ACOUSTIC STIMULATION; ANIMALS; ANOXIA; COCHLEA; COCHLEAR DUCT; COCHLEAR MICROPHONIC POTENTIALS; EAR CANAL; EVOKED POTENTIALS, AUDITORY; FEMALE; GUINEA PIGS; MALE; MICROELECTRODES; ORGAN OF CORTI; OTOACOUSTIC EMISSIONS, SPONTANEOUS; ROUND WINDOW, EAR; TYMPANIC MEMBRANE;

EID: 62949119033     PISSN: 00014966     EISSN: None     Source Type: Journal    
DOI: 10.1121/1.3083228     Document Type: Article

References (70)

1. Bian, L. (2004). " Cochlear compression: Effects of low-frequency biasing on quadratic distortion product otoacoustic emission.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.1819501 116, 3559-3571.
2. Bian, L. (2006). " Spectral fine-structures of low-frequency modulated distortion product otoacoustic emissions.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.2200068 119, 3872-3885.
3. Bian, L., Chertoff, M. E., and Miller, E. (2002). " Deriving a cochlear transducer function from low-frequency modulation of distortion product otoacoustic emissions.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.1488943 112, 198-210.
4. Bian, L., and Scherrer, N. M. (2007). " Low-frequency modulation of distortion product otoacoustic emissions in humans.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.2764467 122, 1681-1692.
5. Brownell, W. E., Bader, C. R., Bertrand, D., and de Ribaupierre, Y. (1985). " Evoked mechanical responses of isolated cochlear outer hair cells.," Science SCIEAS 0036-8075 10.1126/science.3966153 227, 194-196.
6. Chang, K. W., and Norton, S. J. (1996). " The effects of continuous versus interrupted noise exposures on distortion product otoacoustic emissions in guinea pigs.," Hear. Res. HERED3 0378-5955 10.1016/0378-5955(95)00225-1 96, 1-12.
7. Cheatham, M. A., and Dallos, P. (1994). " Stimulus biasing: A comparison between cochlear hair cell and organ of Corti response patterns.," Hear. Res. HERED3 0378-5955 10.1016/0378-5955(94)90061-2 75, 103-113.
8. Corey, D. P., and Hudspeth, A. J. (1979). " Ionic basis of the receptor potential in a vertebrate hair cell.," Nature (London) NATUAS 0028-0836 10.1038/281675a0 281, 675-677.
9. Corey, D. P., and Hudspeth, A. J. (1983). " Analysis of the microphonic potential of the bullfrog's sacculus.," J. Neurosci. 3, 942-961. 0270-6474
10. Crawford, A. C., Evans, M. G., and Fettiplace, R. (1989). " Activation and adaptation of transducer currents in turtle hair cells.," J. Physiol. (London) 419, 405-434. 0022-3751
11. Dallos, P., Billone, M. C., Durrant, J. D., Wang, C., and Raynor, S., (1972). " Cochlear inner and outer hair cells: Functional differences.," Science SCIEAS 0036-8075 10.1126/science.177.4046.356 177, 356-358.
12. Dallos, P. (1970). " Low-frequency auditory characteristics: Species dependence.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.1912163 48, 489-499.
13. Dallos, P. (1992). " The active cochlea.," J. Neurosci. 12, 4575-4585. 0270-6474
14. Davis, H. (1983). " An active process in cochlear mechanics.," Hear. Res. HERED3 0378-5955 10.1016/0378-5955(95)00172-7 9, 79-90.
15. Evans, B. N., and Dallos, P. (1993). " Stereocilia displacement induced somatic motility of cochlear outer hair cells.," Proc. Natl. Acad. Sci. U.S.A. PNASA6 0027-8424 10.1073/pnas.90.18.8347 90, 8347-8351.
16. Frank, G., and Kössl, M. (1996). " The acoustic two-tone distortions 2f1-f2 and f2-f1 and their possible relation to changes in the operating point of the cochlear amplifier.," Hear. Res. HERED3 0378-5955 10.1016/0378-5955(96)00083-4 98, 104-115.
17. Garner, C. A., Neely, S. T., and Gorga, M. P. (2008). " Sources of variability in distortion product otoacoustic emissions.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.2939126 124, 1054-1067.
18. Halsey, K., Skjönsberg, A., Ulfendahl, M., and Dolan, D. F. (2005). " Efferent-mediated adaptation of the DPOAE as a predictor of aminoglycoside toxicity.," Hear. Res. 201, 99-108. 0378-5955
19. Hensel, J., Scholz, G., Hurttig, U., Mrowinski, D., and Janssen, T. (2007). " Impact of infrasound on the human cochlea.," Hear. Res. HERED3 0378-5955 10.1016/j.heares.2007.07.004 233, 67-76.
20. Hirsh, I. J., and Ward, W. D. (1952). " Recovery of the acoustic threshold after strong acoustic stimulation.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.1906867 24, 131-141.
21. Holton, T., and Hudspeth, A. J. (1986). " The transduction channel of hair cells from the bull-frog characterized by noise analysis.," J. Physiol. 375, 195-227. 0022-3751
22. Howard, J., and Hudspeth, A. J. (1988). " Compliance of the hair bundle associated with gating of MET channels in the bullfrog's saccular hair cell.," Neuron NERNET 0896-6273 10.1016/0896-6273(88)90139-0 1, 189-199.
23. Hudspeth, A. J. (2008). " Making an effort to listen: Mechanical amplification in the ear.," Neuron 59, 530-545. 0896-6273
24. Jaramillo, F., Markin, V. S., and Hudspeth, A. J. (1993). " Auditory illusions and the single hair cell.," Nature (London) NATUAS 0028-0836 10.1038/364527a0 364, 527-529.
25. Kemp, D. T. (1986). " Otoacoustic emissions, travelling waves and cochlear mechanisms.," Hear. Res. HERED3 0378-5955 10.1016/0378-5955(86) 90087-0 22, 95-104.
26. Kim, D. O. (1986). " Active and nonlinear cochlear biomechanics and the role of outer-hair-cell subsystem in the mammalian auditory system.," Hear. Res. HERED3 0378-5955 10.1016/0378-5955(86)90088-2 22, 105-114.
27. Kirk, D. L., Moleirinho, A., and Patuzzi, R. B. (1997). " Microphonic and DPOAE measurements suggest a micromechanical mechanism for the bounce' phenomenon following low-frequency tones.," Hear. Res. HERED3 0378-5955 10.1016/S0378-5955(97)00104-4 112, 69-86.
28. Kirk, D. L., and Patuzzi, R. B. (1997). " Transient changes in cochlear potentials and DPOAEs after low-frequency tones: The two-minute bounce' revisited.," Hear. Res. HERED3 0378-5955 10.1016/S0378-5955(97)00105-6 112, 49-68.
29. Kirk, D. L., and Yates, G. K. (1998). " Enhancement of electrically evoked oto-acoustic emissions associated with low-frequency stimulus bias of the basilar membrane towards scala vestibuli.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.424365 104, 1544-1554.
30. Kossowski, M., Mom, T., Guitton, M., Poncet, J. L., Bonfils, P., and Avan, P. (2001). " Fine alterations of distortion-product otoacoustic emissions after moderate acoustic overexposure in guinea pigs.," Audiology 40, 113-122. 0020-6091
31. Kros, C. J. (1996). " Physiology of mammalian cochlear hair cells.," in The Cochlea, Springer Handbook of Auditory Research Vol. 8, edited by, P. Dallos, R. R. Fay, and, A. N. Popper, (Springer US, NY), pp. 318-385.
32. Kujawa, S. G., and Liberman, M. C. (2001). " Effects of olivocochlear feedback on distortion product otoacoustic emissions in guinea pig.," J. Assoc. Res. Otolaryngol. 2, 268-278. 1525-3961
33. Liberman, M. C., Zuo, J., and Guinan, J. J., Jr. (2004). " Otoacoustic emissions without somatic motility: Can stereocilia mechanics drive the mammalian cochlea? " J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.1775275 116, 1649-1655.
34. Lonsbury-Martin, B. L., Harris, F. P., Stagner, B. B., Hawkins, M. D., and Martin, G. K. (1990). " Distortion product emissions in humans. I. Basic properties in normally hearing subjects.," Ann. Otol. Rhinol. Laryngol. Suppl. 147, 3-14. 0096-8056
35. Lukashkin, A. N., and Russell, I. J. (1997). " The voltage dependence of the mechanoelectrical transducer modifies low frequency outer hair cell electromotility in vitro.," Hear. Res. 113, 133-139. 0378-5955
36. Lukashkin, A. N., and Russell, I. J. (1998). " A descriptive model of the receptor potential nonlinearities generated by the hair cell mechanoelectrical transducer.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.421214 103, 973-980.
37. Lukashkin, A. N., and Russell, I. J. (2002). " Modifications of a single saturating non-linearity account for post-onset changes in 2f1-f2 distortion product otoacoustic emission.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.1502903 112, 1561-1568.
38. Marquardt, T., Hensel, J., Mrowinski, D., and Scholz, G., (2007). " Low-frequency characteristics of human and guinea pig cochleae.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.2722506 121, 3628-3638.
39. Mrowinski, D., Scholz, G., Krompass, S., and Nubel, K., (1996). " Diagnosis of endolymphatic hydrops by low-frequency masking.," Audiol. Neuro-Otol. ANEOFO 1420-3030 1, 125-134.
40. Nieder, P., and Nieder, I. (1968a). " Some effects of tonal interactions as seen in the cochlear microphonic.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.1910944 43, 1092-1106.
41. Nieder, P., and Nieder, I. (1968b). " Studies of two-tone interaction as seen in the guinea pig microphonic.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.1911276 44, 1409-1422.
42. Olson, E. S. (2004). " Harmonic distortion in intracochlear pressure and its analysis to explore the cochlear amplifier.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.1645611 115, 1230-1241.
43. Olzowy, B., von Gleichenstein, G., Canis, M., Plesnila, N., and Mees, K. (2008). " Complex level alterations of the 2f (1)-f (2) distortion product due to hypoxia in the guinea pig.," Eur. Arch. Otorhinolaryngol. (in press). 0937-4477
44. Patuzzi, R., and Moleirinho, A. (1998). " Automatic monitoring of mechano-electrical transduction in the guinea pig cochlea.," Hear. Res. HERED3 0378-5955 10.1016/S0378-5955(98)00125-7 125, 1-16.
45. Patuzzi, R., and Rajan, R. (1990). " Does electrical stimulation of the crossed olivo-cochlear bundle produce movement of the organ of Corti? " Hear. Res. HERED3 0378-5955 10.1016/0378-5955(90)90179-S 45, 15-32.
46. Patuzzi, R., and Sellick, P. M. (1983). " A comparison between basilar membrane and inner hair cell receptor potential input-output functions in the guinea pig cochlea.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.390282 74, 1734-1741.
47. Patuzzi, R., Sellick, P. M., and Johnstone, B. M. (1984a). " The modulation of the sensitivity of the mammalian cochlea by low frequency tones. I. Primary afferent activity.," Hear. Res. HERED3 0378-5955 10.1016/S0378-5955(99)00160-4 13, 1-8.
48. Patuzzi, R., Sellick, P. M., and Johnstone, B. M. (1984b). " The modulation of the sensitivity of the mammalian cochlea by low frequency tones. III. Basilar membrane motion.," Hear. Res. HERED3 0378-5955 10.1016/S0378-5955(99)00077-5 13, 19-27.
49. Patuzzi, R. B. (1996). " Cochlear micromechanics and macromechanics.," in The Cochlea, Springer Handbook of Auditory Research Vol. 8, edited by, P. Dallos, R. R. Fay, and, A. N. Popper, (Springer US, NY), pp. 186-257.
50. Patuzzi, R. B., Yates, G. K., and Johnstone, B. M. (1989). " The origin of the low-frequency microphonic in the first cochlear turn of guinea-pig.," Hear. Res. HERED3 0378-5955 10.1016/0378-5955(89)90089-0 39, 177-188.
51. Rebillard, G., and Lavigne-Rebillard, M. (1992). " Effect of reversible hypoxia on the compared time courses of endocochlear potential and 2f1-f2 distortion products.," Hear. Res. HERED3 0378-5955 10.1016/0378-5955(92)90179-Q 62, 142-148.
52. Ruggero, M. A., Robles, L., and Rich, N. C. (1986). " Basilar membrane mechanics at the base of the chinchilla cochlea. II. Responses to low-frequency tones and relationship to microphonics and spike initiation in the VIII nerve.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.394390 80, 1375-1383.
53. Russell, I. J., and Kossl, M. (1992). " Modulation of hair cell voltage responses to tones by low-frequency biasing of the basilar membrane in the guinea pig cochlea.," J. Neurosci. 12, 1587-1601. 0270-6474
54. Salt, A. N., and Demott, J. E. (1999). " Longitudinal endolymph movements and endocochlear potential changes induced by stimulation at infrasonic frequencies.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.427101 106, 847-856.
55. Salt, A. N., Brown, D. J., Hartsock, J. J., and Plontke, S. K. (2009). " Sustained displacements of the organ of Corti and hypersensitivity to infrasound induced by gel injections into the cochlear apex.," Hear. Res. (to be published). 1525-3961
56. Salt, A. N., Hensen, H. E., Gill, R. M., and Sirjani, D. B. (2005). " Even-order distortion as an indicator of endolymphatic hydrops.," in Proceedings of the Fifth International Symposium on Meniere's Disease and Inner Ear Homeostasis Disorders, The House Institute, Los Angeles, CA, edited by, D. J. Lim,.
57. Santos-Sacchi, J. (1991). " Reversible inhibition of voltage-dependent outer hair cell motility and capacitance.," J. Neurosci. 11, 3096-3110. 0270-6474
58. Shera, C. A., and Guinan, J. J., Jr. (1999). " Evoked otoacoustic emissions arise by two fundamentally different mechanisms: A taxonomy for mammalian OAEs.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.426948 105, 782-798.
59. Sinyor, A., and Laszlo, C. A. (1973). " Acoustic behavior of the outer ear of the guinea pig and the influence of the middle ear.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.1914346 54, 916-921.
60. Sirjani, D. B., Salt, A. N., Gill, R. M., and Hale, S. A. (2004). " The influence of transducer operating point on distortion generation in the cochlea.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.1647479 115, 1219-1229.
61. Strelioff, D. (1973). " A computer simulation of the generation and distribution of cochlear potentials.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.1913642 54, 620-629.
62. Takahashi, S., and Santos-Sacchi, J. (1999). " Distortion component analysis of outer hair cell motility-related gating charge.," J. Membr. Biol. JMBBBO 0022-2631 10.1007/s002329900531 169, 199-207.
63. Talmadge, C. L., Long, G. R., Tubis, A., and Dhar, S. (1999). " Experimental confirmation of the two-source interference model for the fine structure of distortion product otoacoustic emissions.," J. Acoust. Soc. Am. JASMAN 0001-4966 10.1121/1.424584 105, 275-292.
64. Valk, W. L., Wit, H. P., and Albers, F. W. (2004). " Evaluation of cochlear function in an acute endolymphatic hydrops model in the guinea pig by measuring low-level DPOAEs.," Hear. Res. 192, 47-56. 0378-5955
65. von B́ḱsy, G. (1960). Experiments in Hearing (McGraw-Hill, New York).
66. Weiss, T. F., and Leong, R. (1985). " A model for signal transmission in an ear having hair cells with free-standing stereocilia. IV. Mechanoelectric transduction stage.," Hear. Res. HERED3 0378-5955 10.1016/0378-5955(85)90167-4 20, 175-195.
67. Xenellis, J. E., Linthicum, F. H., Jr., Webster, P., and Lopez, R. (2004). " Basilar membrane displacement related to endolymphatic sac volume.," Laryngoscope 114, 1953-1959. 0023-852X
68. Yates, G. K., and Kirk, D. L. (1998). " Cochlear electrically evoked emissions modulated by mechanical transduction channels.," J. Neurosci. 18, 1996-2003. 0270-6474
69. Zenner, H. P. (1986). " Motile responses in outer hair cells.," Hear. Res. HERED3 0378-5955 10.1016/0378-5955(86)90082-1 22, 83-90.
70. Zheng, J., Ren, T., and Nuttall, A. (2008). " Exploring the generation of low frequency cochlear microphonic distortion.," Poster Presented at the 31st Midwinter ARO Meeting, AZ, Abstract No. 1119.