Inflammation and disability as risk factors for mortality in elderly acute care patients

Archives of Gerontology and Geriatrics

Volumn 48, Issue 3, 2009, Pages 406-410

  Forasassi, Christine ^a   Golmard, Jean Louis ^b   Pautas, Eric ^a   Piette, François ^a   Myara, Isaac ^a   Raynaud Simon, Agathe ^a  

^a HÔPITAL CHARLES FOIX   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

C reactive protein; Inflammation in elderly; Mortality in acute care settings; Orosomucoid in elderly subjects

Indexed keywords

ALBUMIN; ANTIDEPRESSANT AGENT; C REACTIVE PROTEIN; OROSOMUCOID; PREALBUMIN;

AGED; ALBUMIN BLOOD LEVEL; ARTICLE; BODY WEIGHT; CAUSE OF DEATH; DAILY LIFE ACTIVITY; DECUBITUS; DEMENTIA; DEMOGRAPHY; DEPRESSION; DISABILITY; ELDERLY CARE; EMERGENCY CARE; FEMALE; FUNCTIONAL STATUS; GERIATRIC CARE; GERIATRIC PATIENT; HOSPITAL ADMISSION; HOSPITALIZATION; HUMAN; INFLAMMATION; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; MORTALITY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR;

ACTIVITIES OF DAILY LIVING; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CHI-SQUARE DISTRIBUTION; COMORBIDITY; DISABILITY EVALUATION; FEMALE; HUMANS; INFLAMMATION; LOGISTIC MODELS; MALE; OROSOMUCOID; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; RISK FACTORS; STATISTICS, NONPARAMETRIC;

EID: 62949111302     PISSN: 01674943     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.archger.2008.03.011     Document Type: Article

References (46)

1. Agarwal N., Acevedo F., Leighton L.S., Cayten C.G., and Pitchumoni C.S. Predictive ability of various nutritional variables for mortality in elderly people. Am. J. Clin. Nutr. 48 (1988) 1173-1178
2. Alarcon T., Barcena A., Gonzalez-Montalvo J.I., Penalosa C., and Salgado. Factors predictive of outcome on admission to an acute geriatric ward. Age Ageing 28 (1999) 429-432
3. Allman R.M. Pressure ulcer prevalence, incidence, risk factors and impact. Clin. Geriatr. Med. 13 (1997) 421-436
4. Boekholdt S.M., Keller T.T., Wareham N.J., Luben R., Bingham S.A., Day N.E., Sandhu M.S., Jukema J.W., Kastelein J.J., Hack C.E., and Khaw K.T. Serum levels of type II secretory phospholipase A2 and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 839-846
5. Bonnefoy M., Ayzac L., Ingenbleek Y., Kostka T., Boisson R.C., and Bienvenu J. Usefulness of the prognostic inflammatory and nutritional index (PINI) in hospitalized elderly patients. Int. J. Vitam. Nutr. Res. 68 (1998) 189-195
6. Bouillanne O., Morineau G., Dupont C., Coulombel I., Vincent J.P., Nicolis I., Benazeth S., Cynober L., and Aussel C. Geriatric Nutritional Risk Index: a new index for evaluating at-risk elderly medical patients. Am. J. Clin. Nutr. 82 (2005) 777-783
7. Casiglia E., Spolaore P., Ginocchio G., Colangeli G., Di Menza G., Marchioro M., Mazza M., and Ambrosio G.B. Predictors of mortality in very old subjects aged 80 years or over. Eur. J. Epidemiol. 9 (1993) 577-586
8. Constans T., Bacq Y., Brechot J.L., Guilmot J.L., Choutet P., and Lamisse F. Protein-energy malnutrition in elderly medical patients. J. Am. Geriatr. Soc. 40 (1992) 263-268
9. Constans T., Bruyere A., Grab B., and Rapin C.H. PINI as a mortality index in the hospitalized elderly patient. Int. J. Vitam. Nutr. Res. 62 (1992) 191-192
10. Corti M.C., Guralnik J.M., Salive M.E., and Sorkin J.D. Serum albumin level and physical disability as predictors of mortality in older persons. J. Am. Med. Assoc. 272 (1994) 1036-1042
11. Covinsky K.E., Justice A.C., Rosenthal G.E., Palmer R.M., and Landefeld C.S. Measuring prognosis and case mix in hospitalized elders. J. Gen. Intern. Med. 12 (1997) 203-208
12. Covinsky K.E., Martin G.E., Beyth R.J., Justice A.C., Seygal A.R., and Landefeld C.S. The relationship between clinical assessments of nutritional status and adverse outcomes in older hospitalized medical patients. J. Am. Geriatr. Soc. 47 (1999) 532-538
13. Covinsky K.E., Kahana E., Chin M.H., Palmer R.M., Fortinsky R.H., and Landefeld C.S. Depressive symptoms and 3-year mortality in older hospitalized medical patients. Ann. Intern. Med. 130 (1999) 563-569
14. Covinsky K.E., Palmer R.M., Fortinsky R.H., Counsell S.R., Stewart A.L., Kresevic D., Burant C.J., and Landefeld C.S. Loss of independence in activities of daily living in older adults hospitalized with medical illnesses: increased vulnerability with age. J. Am. Geriatr. Soc. 51 (2003) 451-458
15. Crooks V., Waller S., Smith T., and Hahn T.J. The use of the Karnofsky Performance Scale in determining outcomes and risk in geriatric outpatients. J. Gerontol. Biol. Sci. Med. Sci. 46 (1991) M139-M144
16. Ferguson R.P., O'Connor P., Crabtree B., Batchelor A., Mitchell J., and Coppola D. Serum albumin and prealbumin as predictors of clinical outcomes of hospitalized elderly nursing home residents. J. Am. Geriatr. Soc. 41 (1993) 545-549
17. Fields S.D., Mc Kenzie C.R., Charlson M.E., and Sax F.L. Cognitive impairment: can it predict the course of hospitalized patients?. J. Am. Geriatr. Soc. 34 (1986) 579-585
18. Folstein M.F., Folstein S.E., and McHugh P.R. "Mini Mental State": a practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12 (1975) 189-198
19. Guidet B., Vassal T., and Offenstadt G. Cytokines et nutrition dans les états septiques graves. Nutr. Clin. Metabol. 7 (1993) 79-87 (in French)
20. Harris T.B., Ferrucci L., Tracy R.P., Corti M.C., Wacholder S., Ettinger, Heimovitz H., Cohen H.J., and Wallace R. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am. J. Med. 106. (1999) 506-512
21. Henry O., Jourdan B., and Duviquet M. Analyse de la réponse inflammatoire chez des malades âgés hospitalisés. Presse Med. 150 (1999) 189-194 (in French)
22. Hermann F.R., Safran C., Levkoff S.E., and Minaker K.L. Serum albumin level on admission as a predictor of death, length of stay, and readmission. Arch. Intern. Med. 152 (1992) 125-130
23. Hogarth M.B., Gallimore J.R., Savage P., Palmer A.J., Starr J.M., Bulpitt C.J., and Pepys M.B. Acute phase proteins, C-reactive protein and serum amyloid A protein as prognostic markers in the elderly inpatient. Age Ageing 26 (1997) 153-158
24. Incalzi A.R., Capparella O., Gemma A., Porcedda P., Raccis G., Sommella L., and Carbonin P.U. A simple method of recognizing geriatric patients at risk for death and disability. J. Am. Geriatr. Soc. 40 (1992) 34-38
25. Incalzi R.A., Gemma A., Capparella O., Terranova L., Porcedda P., Tresalti E., and Carbonin P. Predicting mortality and length of stay of geriatric patients in an acute care general hospital. J. Gerontol. Biol. Sci. Med. Sci. 17 (1992) M35-M39
26. Incalzi A.R., Landi F., Cipriani L., Bruno E., Pagano F., Gemma A., and Carbonin P. Nutritional assessment: a primary component of multidimensional geriatric assessment in the acute care setting. J. Am. Geriatr. Soc. 44 (1996) 166-174
27. Katz S., Downs T.D., and Cash H.R. Progress in the development of the index of ADL. Gerontologist 10 (1970) 20-30
28. Lane D., Carroll D., Ring C., Beevers D.G., and Lip G.Y. Mortality and quality of life 12 months after myocardial infarction: effects of depression and anxiety. Psychosom. Med. 63 (2001) 221-230
29. Liu L., Bopp M.M., Roberson P.K., and Sullivan D.H. Undernutrition and risk of mortality in elderly patients within 1 year of hospital discharge. J. Gerontol. A. Biol. Sci. Med. Sci. 57 (2002) M741-M746
30. Menon V., Greene T., Wang X., Pereira A.A., Marcovina S.M., Beck G.J., Kusek J.W., Collins A.J., Levey A.S., and Sarnak M.J. C-reactive protein and albumin as predictors of all-cause and cardiovascular mortality in chronic kidney disease. Kidney Int. 68 (2005) 766-772
31. Minicuci N., Maggi S., Noale M., Trabucchi M., Spolaore P., Crepaldi G., and VELCA Group. Predicting mortality in older patients. The VELCA Study. Aging Clin. Exp. Res. 15 (2003) 328-335
32. Mueller C., Laule-Kilian K., Christ A., Brunner-La Rocca H.P., and Perruchoud A.P. Inflammation and long-term mortality in acute congestive heart failure. Am. Heart J. 151 (2006) 845-850
33. Narain P., Rubenstein L.Z., Wieland G.D., Rosbrook B., Strome L.S., Pietruszka F., and Morley J.E. Predictors of immediate and 6-month outcomes in hospitalized elderly patients. The importance of functional status. J. Am. Geriatr. Soc. 36 (1988) 775-783
34. Pepys M.B. The acute phase response and C-reactive protein. In: Weatherall D.J., Ledingham J.G.G., and Warrrell D.A. (Eds). Oxford Textbook of Medicine. 2nd ed. (1987), Oxford University Press, Oxford 157-164
35. Pinilla J.C., Hayes P., Laverty W., Arnold C., and Laxdal V. The C-reactive protein to prealbumin ratio correlates with the severity of multiple organ dysfunction. Surgery 124 (1998) 799-805
36. Ponzetto M., Maero B., Maina P., Rosato R., Ciccone G., Merletti F., Rubenstein L.Z., and Fabris F. Risk factors for early and late mortality in hospitalized older patients: the continuing importance of functional status. J. Gerontol. A. Biol. Sci. Med. Sci. 58 (2003) M1049-M1054
37. Potter J.F., Schafer D.F., and Bohi R.L. In-hospital mortality as a function of body mass index: an age-dependent variable. J. Gerontol. Biol. Sci. Med. Sci. 43 (1988) M59-M63
38. Raynaud-Simon A., Lafont S., Berr C., Dartigues J.F., and Le Bouc Y. Orosomucoid: a mortality risk factor in elderly people living in the community?. Clin. Nutr. 21 (2002) 45-50
39. Reinhardt G.F., Myscofski J.W., Wilkens D.B., Dobrin P.B., Mangan J.E., and Stannard R.T. Incidence and mortality of hypoalbuminemic patients in hospitalized veterans. J. Parenter. Enteral Nutr. 4 (1980) 357-359
40. Reuben D.B., Cheh A.I., Harris T.B., Ferrucci L., Rowe J.W., Tracy R.P., and Seeman T.E. Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons. J. Am. Geriatr. Soc. 50 (2002) 638-644
41. Rosenthal A.J., McMurtry C.T., Sanders K.M., Jacobs M., Thompson D., and Adler R.A. The soluble interleukin-2 receptor predicts mortality in older hospitalized men. J. Am. Geriatr. Soc. 45 (1997) 1362-1364
42. Ruberman W., Weinblatt E., Goldberg J.D., and Chaudhary B.S. Psychosocial influences on mortality after myocardial infarction. N. Engl. J. Med. 9 (1984) 552-559
43. Satish S., Winograd C.H., Chavez C., and Bloch D.A. Geriatric targeting criteria as predictors of survival and health care utilization. J. Am. Geriatr. Soc. 44 (1996) 914-921
44. Sullivan D.H., Walls R.C., and Lipschitz D.A. Protein-energy undernutrition and the risk of mortality within one year of hospital discharge in a select population of geriatric rehabilitation patients. Am. J. Clin. Nutr. 53 (1991) 599-605
45. Sullivan D.H., Sun S., and Walls R.C. Protein-energy undernutrition among elderly hospitalized patients: a prospective study. J. Am. Med. Assoc. 281 (1999) 2013-1019
46. Walter L.C., Brand R.J., Counsel S.R., Palmer R.M., Landefeld C.S., Fortinsky R.H., and Covinsky K.E. Development and validation of a prognostic index for 1-year mortality in older adults after hospitalization. J. Am. Med. Assoc. 23 (2001) 2987-2994