Reduction of four-and-a-half LIM-protein 2 expression occurs in human left ventricular failure and leads to altered localization and reduced activity of metabolic enzymes

Journal of Thoracic and Cardiovascular Surgery

Volumn 137, Issue 4, 2009, Pages 853-861

  Bovill, Esta ^a   Westaby, Steven ^b   Crisp, Alastair ^c   Jacobs, Shiney ^a   Shaw, Tony ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTO 2 KINASE; ADENYLATE KINASE; CREATINE KINASE MB; LIM 2 PROTEIN; LIM PROTEIN; UNCLASSIFIED DRUG;

AORTA STENOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; GOLGI COMPLEX; HEART FAILURE; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE BIOPSY; HEART VENTRICLE HYPERTROPHY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION;

ADULT; AGED; AORTIC VALVE STENOSIS; FEMALE; HEART FAILURE; HOMEODOMAIN PROTEINS; HUMANS; MALE; MIDDLE AGED; MUSCLE PROTEINS; MYOCYTES, CARDIAC; TRANSCRIPTION FACTORS;

EID: 62849109969     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2008.09.006     Document Type: Article

References (30)

1. Tarantini G., Buja P., Scognamiglio R., Razzolini R., Gerosa G., Isabella G., et al. Aortic valve replacement in severe aortic stenosis with left ventricular dysfunction: determinants of cardiac mortality and ventricular function recovery. Eur J Cardiothorac Surg 24 (2003) 879-885
2. Arimura T., Hayashi T., Matsumoto Y., Shibata H., Hiroi S., Nakamura T., et al. Structural analysis of four and half LIM protein-2 in dilated cardiomyopathy. Biochem Biophys Res Commun 357 (2007) 162-167
3. Matsumoto Y., Hayashi T., Inagaki N., Takahashi M., Hiroi S., Nakamura T., et al. Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy. J Muscle Res Cell Motil 26 (2005) 367-374
4. Lange S., Auerbach D., McLoughlin P., Perriard E., Schafer B.W., Perriard J.C., et al. Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2. J Cell Sci 115 (2002) 4925-4936
5. Wallimann T., Wyss M., Brdiczka D., Nicolay K., and Eppenberger H.M. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the "phosphocreatine circuit" for cellular energy homeostasis. Biochem J 281 (1992) 21-40
6. Dzeja P.P., Redfield M.M., Burnett J.C., and Terzic A. Failing energetics in failing hearts. Curr Cardiol Rep 2 (2000) 212-217
7. O'Brien P.J., and Gwathmey J.K. Myocardial Ca(2+)- and ATP-cycling imbalances in end-stage dilated and ischemic cardiomyopathies. Cardiovasc Res 30 (1995) 394-404
8. Saupe K.W., Spindler M., Tian R., and Ingwall J.S. Impaired cardiac energetics in mice lacking muscle-specific isoenzymes of creatine kinase. Circ Res 82 (1998) 898-907
9. Depre C., Rider M.H., and Hue L. Mechanisms of control of heart glycolysis. Eur J Biochem 258 (1998) 277-290
10. Muller J.M., Isele U., Metzger E., Rempel A., Moser M., Pscherer A., et al. FHL2, a novel tissue-specific coactivator of the androgen receptor. EMBO J 19 (2000) 359-369
11. Van Schaftingen E., Lederer B., and Bartrons R. Hers HG A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate. Eur J Biochem 129 (1982) 191-195
12. Bishop C., Chu T.M., and Shihabi Z.K. Single stable reagent for creatine kinase assay. Clin Chem 17 (1971) 548-550
13. Chu P.H., Ruiz-Lozano P., Zhou Q., Cai C., and Chen J. Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular system. Mech Dev 95 (2000) 259-265
14. Arber S., Hunter J.J., Ross J.J., Hongo M., Sansig G., Borg J., et al. MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Cell 88 (1997) 393-403
15. Pashmforoush M., Pomies P., Peterson K.L., Kubalak S., Ross J.J., Hefti A., et al. Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy. Nat Med 7 (2001) 591-597
16. Radke M.H., Peng J., Wu Y., McNabb M., Nelson O.L., Granzier H., et al. Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy. Proc Natl Acad Sci U S A 104 (2007) 3444-3449
17. Kong Y., Shelton J.M., Rothermel B., Li X., Richardson J.A., Bassel-Duby R., et al. Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. Circulation 103 (2001) 2731-2738
18. Purcell N.H., Darwis D., Bueno O.F., Muller J.M., Schule R., and Molkentin J.D. Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes. Mol Cell Biol 24 (2004) 1081-1095
19. McLoughlin P., Ehler E., Carlile G., Licht J.D., and Schafer B.W. The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein. J Biol Chem 277 (2002) 37045-37053
20. Wojtas K., Slepecky N., von Kalm L., and Sullivan D. Flight muscle function in Drosophila requires colocalization of glycolytic enzymes. Mol Biol Cell 8 (1997) 1665-1675
21. Saks V.A., Tiivel T., Kay L., Novel-Chate V., Daneshrad Z., Rossi A., et al. On the regulation of cellular energetics in health and disease. Mol Cell Biochem 160-161 (1996) 195-208
22. Wixler V., Geerts D., Laplantine E., Westhoff D., Smyth N., Aumailley M., et al. The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. J Biol Chem 275 (2000) 33669-33678
23. Kupershmidt S., Yang I.C., Sutherland M., Wells K.S., Yang T., Yang P., et al. Cardiac-enriched LIM domain protein fhl2 is required to generate I(Ks) in a heterologous system. Cardiovasc Res 56 (2002) 93-103
24. Nagueh S.F., Shah G., Wu Y., Torre-Amione G., King N.M., Lahmers S., et al. Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy. Circulation 110 (2004) 155-162
25. Makarenko I., Opitz C.A., Leake M.C., Neagoe C., Kulke M., Gwathmey J.K., et al. Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts. Circ Res 95 (2004) 708-716
26. Filipeanu C.M., Zhou F., Claycomb W.C., and Wu G. Regulation of the cell surface expression and function of angiotensin II type 1 receptor by Rab1-mediated endoplasmic reticulum-to-Golgi transport in cardiac myocytes. J Biol Chem 279 (2004) 41077-41084
27. Vertessy B.G., Orosz F., Kovacs J., and Ovadi J. Alternative binding of two sequential glycolytic enzymes to microtubules. Molecular studies in the phosphofructokinase/aldolase/microtubule system. J Biol Chem 272 (1997) 25542-25546
28. Parra J., and Pette D. Effects of low-frequency stimulation on soluble and structure-bound activities of hexokinase and phosphofructokinase in rat fast-twitch muscle. Biochim Biophys Acta 1251 (1995) 154-160
29. Srere P.A., and Knull H.R. Location-location-location. Trends Biochem Sci 23 (1998) 319-320
30. Donker D.W., Maessen J.G., Verheyen F., Ramaekers F.C., Spatjens R.L., Kuijpers H., et al. Impact of acute and enduring volume overload on mechanotransduction and cytoskeletal integrity of canine left ventricular myocardium. Am J Physiol Heart Circ Physiol 292 (2007) H2324-H2332