Evaluation of alkyloxycarbonyloxymethyl (AOCOM) ethers as novel prodrugs of phenols for topical delivery: AOCOM prodrugs of acetaminophen

International Journal of Pharmaceutics

Volumn 371, Issue 1-2, 2009, Pages 25-32

  Thomas, Joshua D ^a   Sloan, Kenneth B ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Diffusion cell experiments; Lipid solubility; Prodrugs; Roberts Sloan equation; Topical delivery; Water solubility

Indexed keywords

ETHER DERIVATIVE; MYRISTIC ACID ISOPROPYL ESTER; PARACETAMOL; PHENOL DERIVATIVE; PRODRUG; WATER;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; HAIRLESS MOUSE; MOLECULAR WEIGHT; PH; PRIORITY JOURNAL; TOPICAL TREATMENT;

ACETAMINOPHEN; ADMINISTRATION, CUTANEOUS; ANIMALS; DIFFUSION; ETHERS; FEMALE; MICE; MICE, HAIRLESS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; PHENOLS; PHYSICOCHEMICAL PHENOMENA; PRODRUGS; SKIN; SKIN ABSORPTION;

EID: 62749127197     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.12.020     Document Type: Article

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