Influence of low doses of deoxynivalenol on histopathology of selected organs of pigs

Polish Journal of Veterinary Sciences

Volumn 12, Issue 1, 2009, Pages 89-95

  Zielonka, L ^a   Wisniewska M ^a   Gajecka, M ^a   Obremski, K ^a   Gajecki, M ^a  

^a UNIVERSITY OF WARMIA AND MAZURY IN OLSZTYN   (Poland)

Author keywords

Deoxynivalenol; Mycotoxicosis; Pathological changes

Indexed keywords

TRICHOTHECENE DERIVATIVE; VOMITOXIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; GASTROINTESTINAL DISEASE; INTESTINE; LIVER; LYMPH NODE; PATHOLOGY; SWINE; SWINE DISEASE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTROINTESTINAL DISEASES; INTESTINES; LIVER; LYMPH NODES; SWINE; SWINE DISEASES; TRICHOTHECENES;

ANIMALIA; FUSARIUM; SUIDAE;

EID: 62649174173     PISSN: 15051773     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Azcona-Olivera JI, Ouyang YL, Warner RL, Murtha J, Chu FS, Pestka JJ (1995) Induction of cytokine mRNAs in mice after oral exposure to the trichotecene vomitoxin (deoxynivalenol): Relationship to toxin distribution and protein synthesis inhibition. Toxicol Appl Pharmacol 133: 109-120.
2. Betina V (1989) Structure-activity relationships among mycotoxins. Chem Biol Interact 71: 105-146.
3. Chavez ER, Rheaume JA (1986) The significance of the reduced feed consumption observed in growing pigs fed vomitoxin-contaminated diets. Can J Anim Sci 66: 277-287.
4. De Vries JW, Trucksess MW, Jackson LS (2003) Mycotoxins and food safety. Trends Food Science Technol 14: 111-115.
5. European Commission.: Opinion of the Scientific Committee on Food on Fusarium Toxins: Part 1: deoxynivalenol (DON) - SCF/CS/CNTM/MYC/19 Final with 09 December 1999.
6. Greenhalgh R, Blackwell BA, Savard ME (1989) The NMR spectra of trichothecenes and related fungal metabolites. Tetrahedron 45: 2273-2283.
7. Gutleb AC, Morrison E, Murk AJ (2002) Cytotoxicity assays for mycotoxins produced by Fusarium strains: a review. Environ Toxicol Pharmacol 11: 309-320.
8. Iverson F, Amstrong C, Nea E, Truelove J, Fernie S, Scott PM, Stapley R, Hayward S, Gunner S (1995): Chronic feeding study of deoxynivalenol in B6C3F1 male and female mice. Teratog Carcinog Mutagen 15: 283-306.
9. Lambert LA, Himes FA., Eppley RM (1995): Lack of initiation and promotion potential of deoxynivalenol contamination in barley and oats. Food Chem Toxicol 33: 217-222.
10. Mishra PK, Fox TV, Culham A (2002) Restriction analysis of PCR amplified nrDNA regions revealed intraspecific variation within populations of Fusarium culmorum. FEMS Microbiol Lett 215: 291-242.
11. Pestka JJ, Bondy GS (1994) Mycotoxin-induced immune modulation. In: Dean JH, Luster MI, Munson AE, Kimber I (eds) Immunotoxicology and immunopharmacology. New York, Raven Press, pp 163-182.
12. Prelusky DB, Gerdes R.G, Underhill KL, Rotter BA, Jui PY, Trenholm HL (1994a): Effects of low-level dietary deoxynivalenol on the hematological and clinical parameters of the pig. Natural Toxins 2: 97-104.
13. Prelusky DB, Rotter BA, Rotter RG (1994b): Toxicology of mycotoxins. In: Miller JD, Trenholm HL (eds) Mycotoxins in grain. Compounds other than aflatoxins. Eagan Press, St Paul, Minn, pp 359-403.
14. Robbana-Barnat S, Lafarge-Frayssinet C, Cohen H, Neish GA, Frayssinet C (1988) Immunosupresive properties of deoxynivalenol. Toxicology 48: 155-166.
15. Rotter BA, Prelusky DB, Pestka JJ (1996) Toxicology of deoxynivalenol (Vomitoxin). J Toxicol Environ Health 48: 1-34.
16. Visconti A, Pascale M (1998): Determination of zearalenone in corn by means of immunoaffinity clean-up and high-performance liquid chromatography with fluorescence detection. J Chromatogr A 815: 133-140.
17. Zielonka Ł, Gajecki M, Obremski K, Zwierzchowski W (2003) Influence of low doses of deoxynivalenol applied per os on chosen indexes of immune response in swine. Pol J of Vet Sci 6: 74-77.
18. Zielonka Ł, Gajecki M, Obremski K, Zwierzchowski W (2004) Wpływ niskich dawek deoxynivalenolu podawanych per os na poziom tej mikotoksyny w surowicy krwi świń. Med Weter 60: 534-536.