The total activity of a mixture of okadaic acid-group compounds can be calculated by those of individual analogues in a phosphoprotein phosphatase 2A assay

Toxicon

Volumn 53, Issue 6, 2009, Pages 631-637

  Albano, Clara ^a   Ronzitti, Giuseppe ^a   Rossini, Anna Maria ^b   Callegari, Federica ^a   Rossini, Gian Paolo ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b Liceo Scientifico Statale Leonardo da Vinci   (Italy)

Author keywords

Diarrheic shellfish poisoning; Dinophysistoxins; Mytilus; Okadaic acid; Serine threonine phosphoprotein phosphatases; Toxicity equivalence factors

Indexed keywords

DINOPHYSISTOXIN 1; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 2A;

ARTICLE; CALCULATION; CONCENTRATION RESPONSE; CONSUMER; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; IC 50; MYTILUS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SHELLFISH POISONING;

DOSE-RESPONSE RELATIONSHIP, DRUG; MATHEMATICS; OKADAIC ACID; PROTEIN PHOSPHATASE 2;

MYTILUS;

EID: 62649099155     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2009.01.026     Document Type: Article

References (19)

1. Aune T., Larsen S., Aasen J.A.B., Rehmann N., Satake M., and Hess P. Relative toxicity of dinophysistoxin-2 (DTX2) compared with okadaic acid, based on acute intraperitoneal toxicity in mice. Toxicon 49 (2007) 1-7
2. Bialojan C., and Takai A. Inhibitory effect of a marine sponge toxin, okadaic acid, on protein phosphatases. Biochem. J. 256 (1988) 283-290
3. Clark A.J. General Pharmacology. Handbook of Experimental Pharmacology Vol. 4 (1937), Springer Verlag, Berlin
4. European Commission. Regulation (EC) No 853/2004. Official Journal of the European Communities L139 (2004) 55-205
5. European Commission. Regulation (EC) No 2074/2005. Official Journal of the European Communities L338 (2005) 27-34
6. Hallegraeff G.M. Harmful algal blooms: a global overview. In: Hallegraeff G.M., Anderson D.M., and Cembella A.D. (Eds). Manual on Harmful Marine Microalgae (2004), UNESCO, Paris 25-49
7. Hess P., Grune B., Anderson D.B., Aune T., Botana L.M., Caricato P., van Egmond H.P., Halder M., Hall S., Lawrence J.F., Moffat C., Poletti R., Richmond J., Rossini G.P., Seamer C., and Serratosa Vilageliu J. Three Rs approaches in marine biotoxin testing the report and recommendations of a Joint ECVAM/DG SANCO Workshop (ECVAM Workshop 55). Altern. Labor. Anim. (ATLA) 34 (2006) 193-224
8. Holmes C.F.B. Liquid chromatography-linked protein phosphatase bioassay: a highly sensitive marine bioscreen of okadaic acid and related diarrhetic shellfish toxins. Toxicon 29 (1991) 469-477
9. Langmuir A. The adsorption of gases on plane surfaces of glass, mica and platinum. J. Am. Chem. Soc. 40 (1918) 1361-1403
10. Nishiwaki S., Fujiki H., Suganuma M., Furuya-Suguri H., Matsushima R., Iida Y., Ojika M., Yamada K., Uemura D., Yasumoto T., Schmitz F.J., and Sugimura T. Structure-activity relationship within a series of okadaic acid derivatives. Carcinogenesis 11 (1990) 1837-1841
11. Pavela-Vrančič M., Meštrović V., Marasović I., Gillman M., Furey A., and James K.J. DSP toxin profile in the coastal waters of the central Adriatic Sea. Toxicon 40 (2002) 1601-1607
12. Rossini G.P. Functional assays in marine biotoxin detection. Toxicology 208 (2005) 451-462
13. Simon J.-F., and Vernoux J.-P. Highly sensitive assay of okadaic acid using protein phosphatase and paranitrophenyl phosphate. Nat. Toxins 2 (1994) 293-301
14. Takai A., Murata M., Torigoe K., Isobe M., Mieskes G., and Yasumoto T. Inhibitory effect of okadaic acid derivatives on protein phosphatases. Biochem. J. 284 (1992) 539-544
15. Tubaro A., Florio C., Luxich E., Sosa S., Della Loggia R., and Yasumoto T. A protein phosphatase 2A inhibition assay for a fast and sensitive assessment of okadaic acid contamination in mussels. Toxicon 34 (1996) 743-752
16. Vale P., and Sampayo M.A. Esterification of DSP toxins by Portuguese bivalves from the Northwest coast determined by LC-MS - a widespread phenomenon. Toxicon 40 (2002) 33-42
17. Vieytes M.R., Fontal O.I., Leira F., Baptista de Sousa J.M.V., and Botana L.M. A fluorescent microplate assay for diarrheic shellfish toxins. Anal. Biochem 248 (1997) 258-264
18. Yasumoto T., Murata M., Oshima Y., Sano M., Matsumoto G.K., and Clardy J. Diarrhetic shellfish toxins. Tetrahedron 41 (1985) 1019-1025
19. Yasumoto T., and Murata M. Marine toxins. Chem. Rev. 93 (1993) 1897-1909