Effect of AIF on knee osteoarthritis patients: Double-blind, randomized placebo-controlled study

Korean Journal of Physiology and Pharmacology

Volumn 13, Issue 1, 2009, Pages 33-37

  Park, Sung Hoon ^a   Kim, Seong Kyu ^a   Shin, Im Hee ^a   Kim, Hyung Gun ^b   Choe, Jung Yoon ^a  

^a Catholic University of Daegu   (South Korea)

^b Dankook University   (South Korea)

Author keywords

Anti inflammatory factor; Clinical trial; Herbs; K WOMAC; Osteoarthritis

Indexed keywords

ELEUTHEROCOCCUS SENTICOSUS EXTRACT; PANAX NOTOGINSENG EXTRACT; PLACEBO; REHMANNIA GLUTINOSA EXTRACT;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED STUDY; DISEASE CLASSIFICATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSPEPSIA; DYSURIA; ELEUTHEROCOCCUS SENTICOSUS; FEMALE; GINGIVA PAIN; HUMAN; INSOMNIA; KNEE OSTEOARTHRITIS; KOREA; MAJOR CLINICAL STUDY; MALE; PAIN ASSESSMENT; PANAX NOTOGINSENG; PHYSICAL CAPACITY; RANDOMIZED CONTROLLED TRIAL; REHMANNIA; RHINOPHARYNGITIS; SIDE EFFECT; TREATMENT DURATION; TREATMENT OUTCOME; URTICARIA; VISUAL ANALOG SCALE;

EID: 62649097832     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: 10.4196/kjpp.2009.13.1.33     Document Type: Article

References (19)

1. Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, Christy W, Cooke TD, Greenwald R, Hochberg M. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 29: 1039-1049, 1986.
2. Bae SC, Lee HS, Yun HR, Kim TH, Yoo DH, Kim SY. Cross-cultural adaptation and validation of Korean Western Ontario and McMaster Universities (WOMAC) and Lequesne osteoarthritis indices for clinical research. Osteoarthritis Cartilage 9: 746-750, 2001.
3. Chang SH, Choi Y, Park JA, Jung DS, Shin J, Yang JH, Ko SY, Kim SW, Kim JK. Anti-inflammatory effects of BT-201, an n-butanol extract of Panax notoginseng, observed in vitro and in a collagen-induced arthritis model. Clin Nutr 26: 785-791, 2007.
4. Chang SH, Sung HC, Choi Y, Ko SY, Lee BE, Baek DH, Kim SW, Kim JK. Suppressive effect of AIF, a water extract from three herbs, on collagen-induced arthritis in mice. Int Immunopharmacol 5: 1365-1372, 2005.
5. Christensen R, Bartels EM, Astrup A, Bliddal H. Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage 16: 399-408, 2008.
6. Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JP, Hooper MM, Bradley JD, Bingham CO, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR, Jr., Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJ. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 354: 795-808, 2006.
7. Garstang SV, Stitik TP. Osteoarthritis: epidemiology, risk factors, and pathophysiology. Am J Phys Med Rehabil 85: S11-12, 2006.
8. Kellgren JH, Lawrence JS. Radiological assessment of osteoarthrosis. Ann Rheum Dis 16: 494-502, 1957.
9. Kim HM, An CS, Jung KY, Choo YK, Park JE, Nam SY. Rehmannia glutinosa inhibits tumour necrosis factor-alpha and interleukin-1 secretion from mouse astrocytes. Pharmacol Res 40: 171-176, 1999.
10. Lawrence RC, Helmick CG, Arnett FC, Deyo RA, Felson DT, Giannini EH, Heyse SP, Hirsch R, Hochberg MC, Hunder GG, Liang MH, Pillemer SR, Steen VD, Wolfe F. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 41: 778-799, 1998.
11. Ling S, Nheu L, Dai A, Guo Z, Komesaroff P. Effects of four medicinal herbs on human vascular endothelial cells in culture. Int J Cardiol 128: 350-358, 2008.
12. Martel-Pelletier J. Pathophysiology of osteoarthritis. Osteoarthritis Cartilage 12 Suppl A: S31-33, 2004.
13. McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. Jama 283: 1469-1475, 2000.
14. Ofman JJ, MacLean CH, Straus WL, Morton SC, Berger ML, Roth EA, Shekelle P. A metaanalysis of severe upper gastrointestinal complications of nonsteroidal antiinflammatory drugs. J Rheumatol 29: 804-812, 2002.
15. Peat G, McCarney R, Croft P. Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care. Ann Rheum Dis 60: 91-97, 2001.
16. Pelletier JP, Yaron M, Haraoui B, Cohen P, Nahir MA, Choquette D, Wigler I, Rosner IA, Beaulieu AD. Efficacy and safety of diacerein in osteoarthritis of the knee: a double-blind, placebo-controlled trial. The Diacerein Study Group. Arthritis Rheum 43: 2339-2348, 2000.
17. Spiker B, Kraemer HC, Scott DT, Gross RT. Design issues in a randomized clinical trial of a behavioral intervention: Insights from the infant health and development program. J Deu Behav Pedatr 12: 386-393, 1992.
18. World Medical Association Declaration of Helsinki: Recommendations Guiding Medical Doctors in Biomedical Research Involving Human Subjects. Available at: http://www.net.
19. Zhang W, Moskowitz RW, Nuki G, Abramson S, Altman RD, Arden N, Bierma-Zeinstru S, Brandt KD, Croft P, Doherty M, Dougados M, Hochberg M, Hunter DJ, Kwoh K, Lohmander LS, Tugwell P. OARSI Recommendations for the management of hip and knee osteoarthritis. part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence. Osteoarthritis Cartilage 15: 981-1000, 2007.