The nucleus accumbens core and shell are critical for the expression, but not the consolidation, of Pavlovian conditioned approach

Behavioural Brain Research

Volumn 200, Issue 1, 2009, Pages 22-32

  Blaiss, Cory A ^a,b   Janak, Patricia H ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Appetitive conditioning; Learning; Memory; Nucleus accumbens core; Nucleus accumbens shell; Pavlovian conditioning; Rat

Indexed keywords

ANISOMYCIN; BACLOFEN; MUSCIMOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIORAL RESEARCH; CELL ACTIVATION; CONDITIONED REFLEX; CONDITIONING; CONTROLLED STUDY; INHIBITION KINETICS; MALE; MEMORY CONSOLIDATION; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RAT; REWARD; STATE DEPENDENT LEARNING; TRAINING;

ANALYSIS OF VARIANCE; ANIMALS; ANISOMYCIN; BACLOFEN; BEHAVIOR, ANIMAL; CONDITIONING, CLASSICAL; EXTINCTION, PSYCHOLOGICAL; GABA AGONISTS; MALE; MUSCIMOL; NUCLEUS ACCUMBENS; PROTEIN SYNTHESIS INHIBITORS; RATS; RATS, LONG-EVANS;

EID: 62649097698     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2008.12.024     Document Type: Article

References (51)

1. Mogenson G.J. Limbic-motor integration. In: Epstein A.N. (Ed). Progress in psychobiology and physiological psychology (1987), Academic Press, New York 117-170
2. Mogenson G.J., Jones D.L., and Yim C.Y. From motivation to action: functional interface between the limbic system and the motor system. Prog Neurobiol 14 2-3 (1980) 69-97
3. Cardinal R.N., Parkinson J.A., Hall J., and Everitt B.J. Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci Biobehav Rev 26 (2002) 321-352
4. Balleine B.W. Neural bases of food-seeking: affect, arousal and reward in corticostriatolimbic circuits. Physiol Behav 86 (2005) 717-730
5. Everitt B.J., Parkinson J.A., Olmstead M.C., Arroyo M., Robledo P., and Robbins T.W. Associative processes in addiction and reward: the role of amygdala-ventral striatal subsystems. Ann N Y Acad Sci 877 (1999) 412-438
6. Hernandez P.J., Sadeghian K., and Kelley A.E. Early consolidation of instrumental learning requires protein synthesis in the nucleus accumbens. Nat Neurosci 5 2 (2002) 1327-1331
7. Cardinal R.N., Pennicott D.R., Sugathapala C.L., Robbins T.W., and Everitt B.J. Impulsive choice induced in rats by lesions of the nucleus accumbens core. Science 2929 (2001) 2499-2501
8. Hall J., Parkinson J.A., Connor T.M., Dickinson A., and Everitt B.J. Involvement of the central nucleus of the amygdala and nucleus accumbens core in mediating Pavlovian influences on instrumental behaviour. Eur J Neurosci 13 (2001) 1984-1992
9. Corbit L.H., Muir J.L., and Balleine B.W. The role of the nucleus accumbens in instrumental conditioning: evidence of a functional dissociation between accumbens core and shell. J Neurosci 21 9 (2001) 3251-3260
10. Kelley A.E. Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning. Neurosci Biobehav Rev 27 (2004) 765-776
11. Holland P.C. Conditioned stimulus as a determinant of the form of the Pavlovian conditioned response. J Exp Psychol Anim Behav Process 3 1 (1977) 77-104
12. Boakes R.A. Performance on learning to associate a stimulus with positive reinforcement. In: Davis H., and Hurwitz H.M.B. (Eds). Operant-Pavlovian interactions (1977), Erlbaum, Hillsdale, NJ 67-97
13. Dudai Y. Molecular bases of long-term memories: a question of persistence. Curr Opin Neurobiol 12 (2002) 211-216
14. Dudai Y. The neurobiology of consolidations, or, how stable is the engram?. Annu Rev Psychol 55 (2004) 51-86
15. McGaugh J.L. Memory - a century of consolidation. Science 287 (2000) 248-251
16. Blaiss C.A., and Janak P.H. Post-training, but not post-reactivation, administration of amphetamine and anisomycin modulates Pavlovian conditioned approach. Neurobiol Learn Mem 87 (2007) 644-658
17. Phillips G.D., Setzu E., and Hitchcott P.K. Facilitation of appetitive Pavlovian conditioning by d-amphetamine in the shell, but not the core, of the nucleus accumbens. Behav Neurosci 117 4 (2003) 675-684
18. Cassaday H.J., Horsley R.R., and Norman C. Electrolytic lesions to nucleus accumbens core and shell have dissociable effects on conditioning to discrete and contextual cues in aversive and appetitive procedures respectively. Behav Brain Res 160 (2005) 222-235
19. Setlow B., Holland P.C., and Gallagher M. Disconnection of the basolateral amygdala complex and nucleus accumbens impairs appetitive Pavlovian second-order conditioned response. Behav Neurosci 116 2 (2002) 267-275
20. Parkinson J.A., Olmstead M.C., Burns L.H., Robbins T.W., and Everitt B.J. Dissociation in effects of lesions of the nucleus accumbens core and shell on appetitive Pavlovian approach behavior and the potentiation of conditioned reinforcement and locomotor activity by d-amphetamine. J Neurosci 19 6 (1999) 2401-2411
21. Nader K., Schafe G.E., and LeDoux J.E. Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval. Nature 406 (2000) 722-726
22. Schafe G.E., Nadel N.V., Sullivan G.M., Harris A., and LeDoux J.E. Memory consolidation for contextual and auditory fear conditioning is dependent on protein synthesis, PKA, and MAP kinase. Learn Mem 6 (1999) 97-110
23. Meiri N., and Rosenblum K. Lateral ventricle injection of the protein synthesis inhibitor anisomycin impairs long-term memory in a spatial memory task. Brain Res 789 (1998) 48-55
24. Rosenblum K., Meiri N., and Dudai Y. Taste memory: the role of protein synthesis in gustatory cortex. Behav Neural Biol 59 (1993) 49-56
25. McFarland K., and Kalivas P.W. The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior. J Neurosci 21 21 (2001) 8655-8663
26. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates. 4th ed. (1998), Academic Press, New York
27. Dalley J.W., Laane K., Theobald D.E.H., Armstrong H.C., Corlett P.R., Chudasama Y., and Robbins T.W. Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens. Proc Natl Acad Sci USA 102 17 (2005) 6189-6194
28. Di Ciano P., Cardinal R.N., Cowell R.A., Little S.J., and Everitt B.J. Differential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of Pavlovian approach behavior. J Neurosci 21 23 (2001) 9471-9477
29. Parkinson J.A., Willoughby P.J., Robbins T.W., and Everitt B.J. Disconnection of the anterior cingulate cortex and nucleus accumbens core impairs Pavlovian approach behavior: further evidence for limbic cortical-ventral striatopallidal systems. Behav Neurosci 114 1 (2000) 42-63
30. Everitt B.J., Parkinson J.A., Olmstead M.C., Arroyo M., Robledo P., and Robbins T.W. Associative processes in addiction and reward. Ann N Y Acad Sci 877 (1999) 412-438
31. Groenewegen H.J., Wright C.I., Beijer A.V.J., and Voorn P. Convergence and segregation of ventral striatal inputs and outputs. Ann N Y Academy of Sci 877 (1999) 49-63
32. Ikemoto S. Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. Brain Res Rev 56 (2007) 27-78
33. Usuda I., Tanaka K., and Chiba T. Efferent projections of the nucleus accumbens in the rat with special reference to subdivision of the nucleus: biotinylated dextran amine study. Brain Res 797 (1998) 73-93
34. Voorn P., Vanderschuren L.J.M.J., Groenewegen H.J., Robbins T.W., and Pennartz C.M.A. Putting a spin on the dorsal-ventral divide of the striatum. Trends Neurosci 27 8 (2004) 468-474
35. Yamamoto T. Neural substrates for the processing of cognitive and affective aspects of taste in the brain. Arch Histol Cytol 69 4 (2006) 243-255
36. McDonald A.J. Cortical pathways to the mammalian amygdala. Prog Neurobiol 55 (1998) 257-332
37. LeDoux J.E. Emotion circuits in the brain. Annu Rev Neurosci 23 (2000) 155-184
38. Pickens C.L., Saddoris M.P., Setlow B., Gallagher M., Holland P.C., and Schoenbaum G. Different roles for orbitofrontal cortex and basolateral amygdala in a reinforcer devaluation task. J Neurosci 23 35 (2003) 11078-11084
39. Hatfield T., Han J.S., Conley M., Gallagher M., and Holland P. Neurotoxic lesions of basolateral, but not central, amygdala interfere with Pavlovian second-order conditioning and reinforcer devaluation effects. J Neurosci 16 16 (1996) 5256-5265
40. Gallagher M., Graham P.W., and Holland P.C. The amygdala central nucleus and appetitive Pavlovian conditioning: lesions impair one class of conditioned behavior. J Neurosci 10 6 (1990) 1906-1911
41. 3 dopamine receptor agonist. Pyschopharmacology 133 (1997) 240-248
42. Hitchcott P.K., Harmer C.J., and Phillips G.D. Enhanced acquisition of discriminative approach following intra-amygdala d-amphetamine. Psychopharmacology 132 (1997) 237-246
43. Cardinal R.N., Parkinson J.A., Lachenal G., Halkerston K.M., Rudarakanchana N., Hall J., et al. Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in rats. Behav Neurosci 116 4 (2002) 553-567
44. Yun I.A., Nicola S.M., and Fields H.L. Contrasting effects of dopamine and glutamate receptor antagonist injection in the nucleus accumbens suggest a neural mechanism underlying cue-evoked goal-directed behavior. Eur J Neurosci 20 (2004) 249-263
45. See R.E., Elliott J.C., and Feltenstein M.W. The role of dorsal vs. ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats. Psychopharmacology 194 (2007) 321-331
46. Floresco S.B., Ghods-Sharifi S., Vexelman C., and Magyar O. Dissociable roles for the nucleus accumbens core and shell in regulating set shifting. J Neurosci 26 9 (2006) 2449-2457
47. Gal G., Schiller D., and Weiner I. Latent inhibition is disrupted by nucleus accumbens shell lesion but is abnormally persistent following entire nucleus accumbens lesion: the neural site controlling the expression and disruption of the stimulus preexposure effect. Behav Brain Res 162 2 (2005) 246-255
48. Weiner I., Gal G., and Feldon J. Disrupted and undisruptable latent inhibition following shell and core lesions. Ann N Y Acad Sci 877 (1999) 723-727
49. Weiner I., Gal G., Rawlins J.N., and Feldon J. Differential involvement of the shell and core subterritories of the nucleus accumbens in latent inhibition and amphetamine-induced activity. Behav Brain Res 81 1-2 (1996) 123-133
50. Di Ciano P., Robbins T.W., and Everitt B.J. Differential effects of nucleus accumbens core, shell, or dorsal striatal inactivations on the persistence, reacquisition, or reinstatement of responding for a drug-paired conditioned reinforcer. Neuropsychopharmacology 33 6 (2008) 1413-1425
51. Floresco S.B., McLaughlin R.J., and Haluk D.M. Opposing roles for the nucleus accumbens core and shell in cue-induced reinstatement of food-seeking behavior. Neuroscience 154 3 (2008) 877-884