Cholestane-3β,5α,6β-triol-induced reactive oxygen species production promotes mitochondrial dysfunction in isolated mice liver mitochondria

Chemico-Biological Interactions

Volumn 179, Issue 2-3, 2009, Pages 81-87

  Liu, Hongmei ^a,b   Wang, Tiebing ^a   Huang, Kaixun ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica   (China)

Author keywords

Cholestane 3 ,5 ,6 triol; Mitochondrial dysfunction; Reactive oxygen species

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; BUTYLCRESOL; CHOLESTANE 3BETA,5ALPHA,6BETA TIOL; CYTOCHROME C; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; MEMBRANE LIPID; MEMBRANE PROTEIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; OXYGEN; OXYSTEROL; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); THIOL; TRIOL; UNCLASSIFIED DRUG; CHOLESTANE 3,5,6 TRIOL; CHOLESTANE-3,5,6-TRIOL; CHOLESTANOL; CHOLESTEROL; DRUG DERIVATIVE; SUPEROXIDE DISMUTASE; THIOL DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ELECTRON TRANSPORT; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LIVER MITOCHONDRION; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATIVE STRESS; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; ENZYMOLOGY; METABOLISM; PATHOLOGY;

MUS;

ANIMALS; APOPTOSIS; CHOLESTANOLS; CHOLESTEROL; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; LIPID PEROXIDATION; MICE; MITOCHONDRIA, LIVER; OXYGEN; REACTIVE OXYGEN SPECIES; SULFHYDRYL COMPOUNDS; SUPEROXIDE DISMUTASE;

EID: 62549166233     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.12.003     Document Type: Article

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