Condensed 1,4-dihydropyridines with various esters and their calcium channel antagonist activities

European Journal of Medicinal Chemistry

Volumn 44, Issue 5, 2009, Pages 2052-2058

  Bülbül, Bahadir ^a   Öztürk, Gökçe Sevim ^b   Vural, Mert ^b   Şimşek, Rahime ^a   Sarioǧlu, Yusuf ^b   Linden, Anthony ^c   Ülgen, Mert ^d   Şafak, Cihat ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b GAZI UNIVERSITY   (Turkey)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d MARMARA UNIVERSITY   (Turkey)

Author keywords

Biotransformation; Calcium antagonistic activity; Furoquinoline; Hexahydroquinoline

Indexed keywords

1,4 DIHYDROPYRIDINE DERIVATIVE; 2 METHOXYETHYL 2,6,6 TRIMETHYL 4 (2 FLUORO 3 CHLORO 5 TRIFLUOROMETHYLPHENYL) 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; 2 METHOXYETHYL 2,7,7 TRIMETHYL 4 (2 FLUORO 3 CHLORO 5 TRIFLUOROMETHYLPHENYL) 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; 9 (3 CHLORO 2 FLUORO 5 TRIFLUOROMETHYLPHENYL) 6,6 DIMETHYL 6,7 DIHYDROFURO [3,4 B]QUINOLINE 1,8 DIONE; 9 (3 CHLORO 2 FLUORO 5 TRIFLUOROMETHYLPHENYL) 7,7 DIMETHYL 6,7 DIHYDROFURO [3,4 B]QUINOLINE 1,8 DIONE; ALLYL 2,6,6 TRIMETHYL 4 (2 FLUORO 3 CHLORO 5 TRIFLUOROMETHYLPHENYL) 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; ALLYL 2,7,7 TRIMETHYL 4 (2 FLUORO 3 CHLORO 5 TRIFLUOROMETHYLPHENYL) 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; BENZYL 2,6,6 TRIMETHYL 4 (2 FLUORO 3 CHLORO 5 TRIFLUOROMETHYLPHENYL) 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; CALCIUM CHANNEL BLOCKING AGENT; ETHYL 2,6,6 TRIMETHYL 4 (2 FLUORO 3 CHLORO 5 TRIFLUOROMETHYLPHENYL) 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 2,7,7 TRIMETHYL 4 (2 FLUORO 3 CHLORO 5 TRIFLUOROMETHYLPHENYL) 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; ISOBUTYL 2,6,6 TRIMETHYL 4 (2 FLUORO 3 CHLORO 5 TRIFLUOROMETHYLPHENYL) 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; ISOBUTYL 2,7,7 TRIMETHYL 4 (2 FLUORO 3 CHLORO 5 TRIFLUOROMETHYLPHENYL) 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; METHYL 2,6,6 TRIMETHYL 4 (2 FLUORO 3 CHLORO 5 TRIFLUOROMETHYLPHENYL) 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; METHYL 2,7,7 TRIMETHYL 4 (2 FLUORO 3 CHLORO 5 TRIFLUOROMETHYLPHENYL) 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; NIFEDIPINE; QUINOLINE DERIVATIVE; TERBUTYL 2,6,6 TRIMETHYL 4 (2 FLUORO 3 CHLORO 5 TRIFLUOROMETHYLPHENYL) 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; NONHUMAN; RABBIT; SIGMOID;

ANIMALS; CALCIUM CHANNEL BLOCKERS; COLON; DIHYDROPYRIDINES; ESTERS; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 62549150759     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.10.008     Document Type: Article

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