Probing replacement of pyrophosphate via click chemistry; synthesis of UDP-sugar analogues as potential glycosyl transferase inhibitors

Carbohydrate Research

Volumn 344, Issue 5, 2009, Pages 586-591

  Yeoh, Kar Kheng ^a   Butters, Terry D ^b   Wilkinson, Brendan L ^a   Fairbanks, Antony J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Click chemistry; Glycosyl transferases; Huisgen cycloaddition; Triazoles; UDP sugars

Indexed keywords

CLICK CHEMISTRY; GLYCOSYL TRANSFERASES; HUISGEN CYCLOADDITION; TRIAZOLES; UDP-SUGARS;

CYCLOADDITION; ENZYMES; INTERNET PROTOCOLS; SUGAR (SUCROSE);

SUGARS;

[1' (5'' DEOXYURIDIN) 1'H 1',2',3' TRIAZOL 4' YL] METHYL 2 ACETAMIDO 2 DEOXY ALPHA DEXTRO GALACTOPYRANOSIDE; [1' (5'' DEOXYURIDIN) 1'H 1',2',3' TRIAZOL 4' YL] METHYL 2 ACETAMIDO 2 DEOXY ALPHA DEXTRO GLUCOPYRANOSIDE; [1' (5'' DEOXYURIDIN) 1'H 1',2',3' TRIAZOL 4' YL] METHYL ALPHA DEXTRO GALACTOPYRANOSIDE; [1' (5'' DEOXYURIDIN) 1'H 1',2',3' TRIAZOL 4' YL] METHYL ALPHA DEXTRO GLUCOPYRANOSIDE; CUPROUS ION; GLYCOSIDE; GLYCOSYLTRANSFERASE; GLYCOSYLTRANSFERASE INHIBITOR; PROP 2 YNL 2 ACETAMIDO 2 DEOXY ALPHA DEXTRO GALACTOPYRANOSIDE; PROP 2 YNL 2 ACETAMIDO 2 DEOXY ALPHA DEXTRO GLUCOPYRANOSIDE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE SUGAR;

AQUEOUS SOLUTION; ARTICLE; CATALYSIS; CYCLOADDITION; DRUG SYNTHESIS; ENZYME ACTIVITY; INHIBITION KINETICS; PRIORITY JOURNAL;

ANIMALS; CATTLE; GLYCOSYLTRANSFERASES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MOLECULAR STRUCTURE; N-ACETYLLACTOSAMINE SYNTHASE; TRIAZOLES; URIDINE DIPHOSPHATE SUGARS;

BOVINAE;

EID: 62549136120     PISSN: 00086215     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carres.2009.01.001     Document Type: Article

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