PDGF-A promoter and enhancer elements provide efficient and selective antineoplastic gene therapy in multiple cancer types

Cancer Gene Therapy

Volumn 16, Issue 4, 2009, Pages 298-309

  Mishra, A ^a,b   Ormerod, A K ^a   Cibull, M L ^a   Spear, B T ^a   Kraner, S D ^a   Kaetzel, D M ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenovirus; Enhancer; Platelet derived growth factor; Promoter; Transcription

Indexed keywords

ADENOVIRUS VECTOR; GANCICLOVIR; PLATELET DERIVED GROWTH FACTOR A; THYMIDINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER GENE THERAPY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; FEMALE; GENE EXPRESSION; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; SUICIDE GENE THERAPY; TUMOR CELL; TUMOR VASCULARIZATION;

ANIMALS; ANTIVIRAL AGENTS; APOPTOSIS; CELL LINE, TUMOR; COMBINED MODALITY THERAPY; ENHANCER ELEMENTS, GENETIC; FEMALE; GANCICLOVIR; GENE THERAPY; HUMANS; MICE; NEOPLASMS; PLATELET-DERIVED GROWTH FACTOR; PROMOTER REGIONS, GENETIC; THYMIDINE KINASE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ADENOVIRIDAE; MUS MUSCULUS;

EID: 62549135660     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2008.92     Document Type: Article

References (47)

1. Silver BJ. Platelet-derived growth factor in human malignancy. Biofactors 1992; 86: 217-227.
2. Heldin C-H, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 1999; 79: 1283-1316.
3. Sariban E, Sitaras NM, Antoniades HN, Kufe DW, Pantazis P. Expression of platelet-derived growth factor (PDGF)-related transcripts and synthesis of biologically active PDGF-like proteins by human malignant epithelial cell lines. J Clin Invest 1988; 82: 1157-1164.
4. Fudge K, Bostwick DG, Stearns ME. Platelet-derived growth factor A and B chains and the α and β receptors in prostatic intraepithelial neoplasia. Prostate 1996; 29: 282-286.
5. Beauchamp RD, Lyons RM, Yang EY, Coffey Jr RJ, Moses HL. Expression of and response to growth regulatory peptides by two human pancreatic carcinoma cell lines. Pancreas 1990; 5: 369-380.
6. Cantley L, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R et al. Oncogenes and signal transduction. Cell 1991; 64: 281-302.
7. Pietras K, Sjoblom T, Rubin K, Heldin CH, Ostman A. PDGF receptors as cancer drug targets. Cancer Cell 2003; 3: 439-443.
8. Bonthron DT, Morton CC, Orkin SH, Collins T. Platelet-derived growth factor A-chain: gene structure, chromosomal location, and basis for alternative mRNA splicing. Proc Natl Acad Sci USA 1988; 85: 1492-1496.
9. Kaetzel Jr DM, Maul RS, Liu B, Bonthron D, Fenstermaker RA, Coyne DW. Platelet-derived growth factor A-chain gene transcription is mediated by positive and negative regulatory regions in the promoter. Biochem J 1994; 301: 321-327.
10. Zhang Q, Pedigo N, Shenoy S, Khalili K, Kaetzel DM. Purα activates PDGF-A gene transcription via interactions with a G-rich, single-stranded region of the promoter. Gene 2005; 348C: 25-32.
11. Gashler AL, Bonthron DT, Madden SL, Rauscher III FJ, Collins T, Sukhatme VP. Human platelet-derived growth factor A-chain is transcriptionally repressed by the Wilms tumor suppressor WT1. Proc Natl Acad Sci USA 1992; 89: 10984-10988.
12. Wang Z-Y, Madden SL, Deuel TF, Rauscher III FJ. The Wilms' tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene. J Biol Chem 1992; 267: 21999-22002.
13. Khachigian LM, Santiago FS, Rafty LA, Chan OL, Delbridge GJ, Bobik A et al. GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury. Circ Res 1999; 84: 1258-1267.
14. Rafty LA, Santiago FS, Khachigian LM. NF1/X represses PDGF A-chain transcription by interacting with Sp1 and antagonizing Sp1 occupancy of the promoter. EMBO J 2002; 21: 334-343.
15. Maul RS, Zhang HX, Reid JD, Pedigo NG, Kaetzel DM. Identification of a cell type-specific enhancer in the distal 5′-region of the platelet-derived growth factor A-chain gene. J Biol Chem 1998; 273: 33239-33246.
16. Pedigo N, Zhang H, Koszewski NJ, Kaetzel DM. A 5′-distal element mediates vitamin D-inducibility of PDGF-A gene transcription. Growth Factors 2003; 21: 151-160.
17. Pedigo NG, Mishra A, Zhang H-X, McCorkle JR, Ormerod AK, Kaetzel DM. Retinoic acid-inducibility of the human PDGF-A gene is mediated by 5′-distal DNA motifs that overlap with basal enhancer and vitamin D response elements. Gene Expr 2007; 14: 1-12.
18. Pedigo NG, Zhang H, Bruno ECM, Kaetzel CS, Dugan AR, Shanehsaz P et al. A 5′-distal enhanceosome in the PDGF-A gene is activated in choriocarcinoma cells via ligand-independent binding of vitamin D receptor and constitutive jun kinase signaling. Oncogene 2005; 24: 2654-2666.
19. McKnight SL. The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene. Nucleic Acids Res 1980; 8: 5949-5964.
20. Heckert LL, Schultz K, Nilson JH. Different composite regulatory elements direct expression of the human alpha subunit gene to pituitary and placenta. J Biol Chem 1995; 270: 26497-26504.
21. Huang MC, Li KK, Spear BT. The mouse alpha-fetoprotein promoter is repressed in HepG2 hepatoma cells by hepatocyte nuclear factor-3 (FOXA). DNA Cell Biol 2002; 21: 561-569.
22. Long L, Spear BT. FoxA proteins regulate H19 endoderm enhancer E1 and exhibit developmental changes in enhancer binding in vivo. Mol Cell Biol 2004; 24: 9601-9609.
23. Kanegae Y, Makimura M, Saito I. A simple and efficient method for purification of infectious recombinant adenovirus. Jpn J Med Sci Biol 1994; 47: 157-166.
24. Gonzalez M, Ruggiero FP, Chang Q, Shi YJ, Rich MM, Kraner S et al. Disruption of Trkb-mediated signaling induces disassembly of postsynaptic receptor clusters at neuromuscular junctions. Neuron 1999; 24: 567-583.
25. De Lean A, Munson PJ, Rodbard D. Simultaneous analysis of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol 1978; 235: E97-E102.
26. Kaetzel DM. Transcription of the platelet-derived growth factor A-chain gene. Cytokine Growth Factor Rev 2003; 14: 427-446.
27. Bokar JA, Keri RA, Farmerie TA, Fenstermaker RA, Andersen B, Hamernik DL et al. Expression of the glycoprotein hormone alpha-subunit gene in the placenta requires a functional cyclic AMP response element, whereas a different cis-acting element mediates pituitary-specific expression. Mol Cell Biol 1989; 9: 5113-5122.
28. Spear BT, Tilghman SM. Role of alpha-fetoprotein regulatory elements in transcriptional activation in transient heterokaryons. Mol Cell Biol 1990; 10: 5047-5054.
29. Yoo-Warren H, Pachnis V, Ingram RS, Tilghman SM. Two regulatory domains flank the mouse H19 gene. Mol Cell Biol 1988; 8: 4707-4715.
30. Betsholtz C, Johnsson A, Heldin C-H, Westermark B, Lind P, Urdea MS et al. cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines. Nature 1986; 320: 695-699.
31. Lindner V, Reidy MA. Platelet-derived growth factor ligand and receptor expression by large vessel endothelium in vivo. Am J Pathol 1995; 146: 1488-1497.
32. Sjolund M, Hedin U, Sejersen T, Heldin CH, Thyberg J. Arterial smooth muscle cells express platelet-derived growth factor (PDGF) A chain mRNA, secrete a PDGF-like mitogen, and bind exogenous PDGF in a phenotype- and growth state-dependent manner. J Cell Biol 1988; 106: 403-413.
33. Majesky MW, Benditt EP, Schwartz SM. Expression and developmental control of platelet-derived growth factor A-chain and B-chain/Sis genes in rat aortic smooth muscle cells. Proc Natl Acad Sci USA 1988; 85: 1524-1528.
34. Anan K, Morisaki T, Katano M, Ikubo A, Kitsuki H, Uchiyama A et al. Vascular endothelial growth factor and platelet-derived growth factor are potential angiogenic and metastatic factors in human breast cancer. Surgery 1996; 119: 333-339.
35. Lippman ME, Dickson RB, Gelmann EP. Autocrine and paracrine growth regulation of human breast cancer. J Cell Biochem 1987; 35: 1-16.
36. Peres R, Betsholtz C, Westermark B, Heldin CH. Frequent expression of growth factors for mesenchymal cells in human mammary carcinoma cell lines. Cancer Res 1987; 47: 3425-3429.
37. Kalthoff H, Roeder C, Humburg I, Thiele HG, Greten H, Schmiegel W. Modulation of platelet-derived growth factor A- and B-chain/c-sis mRNA by tumor necrosis factor and other agents in adenocarcinoma cells. Oncogene 1991; 6: 1015-1021.
38. Westermark B, Johnsson A, Paulsson Y, Betsholtz C, Heldin CH, Herlyn M et al. Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor. Proc Natl Acad Sci USA 1986; 83: 7197-7200.
39. Shih IM, Herlyn M. Autocrine and paracrine roles for growth factors in melanoma. In Vivo 1994; 8: 113-123.
40. Leveen P, Claesson-Welsh L, Heldin C-H, Westermark B, Betsholtz C. Expression of mRNAs for platelet-derived growth factor and its receptors in human sarcoma cell lines. Int J Sci 1990; 46: 1066-1070.
41. George D. Targeting PDGF receptors in cancer - rationales and proof of concept clinical trials. Adv Exp Med Biol 2003; 532: 141-151.
42. Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK et al. Malignant glioma: genetics and biology of a grave matter. Genes Dev 2001; 15: 1311-1333.
43. Ma D, Nutt CL, Shanehsaz P, Peng X, Louis DN, Kaetzel DM. Autocrine PDGF-dependent gene expression in glioblastoma cells is mediated largely by activation of the transcription factor SRE-BP, and is associated with altered genotype and patient survival in human brain tumors. Cancer Res 2005; 65: 5523-5534.
44. Liu Q, Muruve DA. Molecular basis of the inflammatory response to adenovirus vectors. Gene Ther 2003; 10: 935-940.
45. Dong C, Davis RJ, Flavell RA. MAP kinases in the immune response. Annu Rev Immunol 2002; 20: 55-72 e-pub 4 October 2001: 55-72.
46. Jackson DA, Juranek S, Lipps HJ. Designing nonviral vectors for efficient gene transfer and long-term gene expression. Mol Ther 2006; 14: 613-626.
47. Lai CM, Lai YK, Rakoczy PE. Adenovirus and adeno-associated virus vectors. DNA Cell Biol 2002; 21: 895-913.