Effects of iron depletion on Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) and trophozoite growth: Implications for antiamoebic therapy

Journal of Antimicrobial Chemotherapy

Volumn 63, Issue 4, 2009, Pages 675-678

  Espinosa, Avelina ^a   Perdrizet, George ^a   Paz y Miño C , Guillermo ^b   Lanfranchi, Regine ^a   Phay, Monichan ^a  

^a ROGER WILLIAMS UNIVERSITY   (United States)

^b UNIVERSITY OF MASSACHUSETTS DARTMOUTH   (United States)

Author keywords

AdhE; E. histolytica; Enzyme inhibition

Indexed keywords

1,10 PHENANTHROLINE; ALCOHOL DEHYDROGENASE 2; ALDEHYDE DEHYDROGENASE; IRON; OXIDOREDUCTASE; UNCLASSIFIED DRUG; ZINC SULFATE;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ENTAMOEBA HISTOLYTICA; ENZYME ACTIVITY; IRON BINDING CAPACITY; IRON CHELATION; NONHUMAN; PARASITE DEVELOPMENT; PARASITE SURVIVAL; TROPHOZOITE;

ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ANIMALS; ENTAMOEBA HISTOLYTICA; IRON; IRON CHELATING AGENTS; MICROBIAL VIABILITY; PROTEIN BINDING; TROPHOZOITES;

EID: 62549125459     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkp015     Document Type: Article

References (13)

1. Stanley SL Jr. Amoebiasis. Lancet 2003; 361: 1025-34.
2. Ali V, Nozaki T. Current therapeutics, their problems, and sulfur-containing-amino-acid metabolism as a novel target against infections by 'amitochondriate' protozoan parasites. Clin Microbiol Rev 2007; 20: 164-87.
3. Espinosa A, Yan L, Zhang ZL et al. The bifunctional Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) protein is necessary for amoebic growth and survival and requires an intact C-terminal domain for both alcohol dehydrogenase and acetaldehyde dehydrogenase activity. J Biol Chem 2001; 276: 20136-43.
4. Espinosa A, Clark D, Stanley SL Jr. Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) as a target for anti-amoebic agents. J Antimicrob Chemother 2004; 54: 56-9.
5. Bullen JJ, Rogers HJ, Spalding PB et al. Natural resistance, iron and infection: A challenge for clinical medicine. J Med Microbiol 2006; 55: 251-8.
6. Vallee BL, Rupley JA, Coombs TL et al. The role of zinc in carboxypeptidase. J Biol Chem 1960; 235: 64-9.
7. Chen M, Li E, Stanley SL Jr. Structural analysis of the acetaldehyde dehydrogenase activity of Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2), a member of the ADHE enzyme family. Mol Biochem Parasitol 2004; 137: 201-5.
8. Echave P, Tamarit J, Cabiscol E et al. Novel antioxidant role of alcohol dehydrogenase E from Escherichia coli. J Biol Chem 2003; 278: 30193-8.
9. Ulijasz AT, Andes DR, Glasner JD et al. Regulation of iron transport in Streptococcus pneumoniae by RitR, an orphan response regulator. J Bacteriol 2004; 186: 8123-36.
10. Murray MJ, Murray A, Murray CJ. The salutary effect of milk on amoebiasis and its reversal by iron. Br Med J 1980; 280: 1351-2.
11. Makkar RP, Sachdev GK, Malhotra V. Alcohol consumption, hepatic iron load and the risk of amoebic liver abscess: A case-control study. Intern Med 2003; 42: 644-9.
12. León-Sicairos N, Reyes-López M, Ordaz-Pichardo C et al. Microbicidal action of lactoferrin and lactoferricin and their synergistic effect with metronidazole in Entamoeba histolytica. Biochem Cell Biol 2006; 84: 327-36.
13. Latour NG, Reeves RE. An iron-requirement for growth of Entamoeba histolytica in culture, and the antiamebal activity of 7-iodo-8-hydroxy-quinoline-5-sulfonic acid. Exp Parasitol 1965; 17: 203-9.