DNA bridging of yeast chromosomes VIII leads to near-reciprocal translocation and loss of heterozygosity with minor cellular defects

Chromosoma

Volumn 118, Issue 2, 2009, Pages 179-191

  Tosato, Valentina ^a   Nicolini, Claudio ^b   Bruschi, Carlo V ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL DNA;

ARTICLE; CELL CYCLE; CHROMOSOME 7; CHROMOSOME REARRANGEMENT; DIPLOIDY; FUNGAL STRAIN; GENE DELETION; GENE EXPRESSION REGULATION; GENE MUTATION; GENE TARGETING; GENETIC RECOMBINATION; HEMIZYGOSITY; HETEROZYGOSITY LOSS; HOMOLOGOUS RECOMBINATION; MITOSIS; NONHUMAN; RECIPROCAL CHROMOSOME TRANSLOCATION; YEAST CELL;

CELL CYCLE; CHROMOSOMES, FUNGAL; DNA, FUNGAL; GENE DELETION; GENE EXPRESSION; GENES, FUNGAL; KANAMYCIN RESISTANCE; LOSS OF HETEROZYGOSITY; MEMBRANE TRANSPORT PROTEINS; MODELS, GENETIC; MUTAGENESIS, INSERTIONAL; MUTATION; PHENOTYPE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSLOCATION, GENETIC;

EID: 62549124536     PISSN: 00095915     EISSN: 14320886     Source Type: Journal    
DOI: 10.1007/s00412-008-0187-z     Document Type: Article

References (36)

1. Bruschi CV, Howe GA (1988) High frequency FLP-independent homologous DNA recombination of 2μ plasmid in the yeast Saccharomyces cerevisiae. Curr Genet 14:191-199
2. Cahill D, Connor B, Carney JP (2006) Mechanisms of eukaryotic DNA double strand break repair. Front Biosci 11:1958-1976
3. Chenevert JM, Naumovski L, Dumas LB, Friedberg EC (1984) Use of plasmid-mediated resistance to the antibiotic G418 for the rapid screening of a yeast mutant library. J Exp Pathol 1:307-313
4. Chizhikov V, Chikina S, Gasparian A, Zborovskaya I, Steshina E, Ungiadze G, Samsonova M, Chernyaev A, Chuchalin A, Tatosyan A (2002) Molecular follow-up of preneoplastic lesions in bronchial epithelium of former Chernobyl clean-up workers. Oncogene 21:2398-2405
5. Daigaku Y, Mashiko S, Mishiba K, Yamamura S, Ui A, Enomoto T, Yamamoto K (2006) Loss of heterozygosity in yeast can occur by ultraviolet irradiation during the S phase of the cell cycle. Mutat Res 600:177-183
6. Gjuracic K, Pivetta E, Bruschi CV (2004) Targeted DNA integration within different functional gene domains in yeast reveals ORF sequences as recombinational cold-spots. Mol Genet Genom 271:437-446
7. Gray M, Honigberg SM (2001) Effect of chromosomal locus, GC content and length of homology on PCR-mediated targeted gene replacement in Saccharomyces. Nucleic Acids Res 29:5156-5162
8. Haigis KM, Dove WF (2003) A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity. Nat Genet 33:33-39
9. Haigis KM, Caya JG, Reichelderfer M, Dove WF (2002) Intestinal adenomas can develop with a stable karyotype and stable microsatellites. Proc Natl Acad Sci U S A 99:8927-8931
10. Hastings PJ, McGill C, Shafer B, Strathern JN (1993) Ends-in vs. ends-out recombination in yeast. Genetics 135:973-980
11. Inbar O, Kupiec M (1999) Homology search and choice of homologous partner during mitotic recombination. Mol Cell Biol 19:4134-4142
12. Ito H, Fukuda Y, Murata K, Kimura A (1983) Transformation of intact yeast cells treated with alkali cations. J Bacteriol 153:163-168
13. Janoueix-Lerosey I, Hupe P, Maciorowski Z, La Rosa P, Schleiermacher G, Pierron G, Liva S, Barillot E, Delattre O (2005) Preferential occurrence of chromosome breakpoints within early replicating regions in neuroblastoma. Cell Cycle 4:1842-1846
14. Kaiser C, Michaelis S, Mitchell A (1994) Preparation of chromosome-sized yeast DNA molecules in solid agarose. In: CSH Methods in yeast genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp 179-180
15. Kool M, de Haas M, Scheffer GL, Scheper RJ, van Eijk MJ, Juijn JA, Baas F, Borst P (1997) Analysis of expression of cMOAT (MRP2), MRP3, MRP4, andMRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res 57:3537-3547
16. Lander JK, Fan H (1997) Low-frequency loss of heterozygosity in Moloney murine leukemia virus-induced tumors in BRAKF1/J mice. J Virol 71:3940-3952
17. Langston LD, Symington LS (2004) Gene targeting in yeast is initiated by two independent strand invasions. Proc Natl Acad Sci U S A 101:15392-15397
18. Moore JK, Haber JE (1996) Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mol Cell Biol 16:2164-2173
19. Morrow DM, Connelly C, Hieter P (1997) "Break copy" duplication: A model for chromosome fragment formation in Saccharomyces cerevisiae. Genetics 147:371-382
20. Nicolini C (2006) Nanogenomics for medicine. Nanomed 1:147-52 Review
21. Nikitin D, Tosato V, Zavec AB, Bruschi CV (2008) Cellular and molecular effects of non-reciprocal chromosome translocations in S. cerevisiae. Proc Natl Acad Sci 105:9703-9708
22. Norris MD, Smith J, Tanabe K, Tobin P, Flemming C, Scheffer GL, Wielinga P, Cohn SL, London WB, Marshall GM, Allen JD, Haber M (2005) Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro. Mol Cancer Ther 4:547-553
23. Pan H, Califano J, Ponte JF, Russo AL, Cheng KH, Thiagalingam A, Nemani P, Sidransky D, Thiagalingam S (2005) Loss of heterozygosity patterns provide fingerprints for genetic heterogeneity in multistep cancer progression of tobacco smoke-induced non-small cell lung cancer. Cancer Res 65:1664-1669
24. Reifenberger J, Reifenberger G, Liu L, James CD, Wechsler W, Collins VP (1994) Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p. Am J Pathol. 145:1175-1190
25. Sambrook J, Fritsch EF, Maniatis T (1989) Analysis of genomic DNA by Southern hybridizAtion. In: CSH Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp 9.31-9.58
26. Smith CE, Llorente B, Symington LS (2007) Template switching during break-induced replication. Nature 447:102-105
27. Stark JM, Jasin M (2003) Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks. Mol Cell Biol 23:733-743
28. Storici F, Coglievina M, Bruschi CV (1999) A 2-micron DNA-based marker recycling system for multiple gene disruption in the yeast Saccharomyces cerevisiae. Yeast 15:271-283
29. Tosato V, Waghmare SK, Bruschi CV (2005) Non-reciprocal chromosomal bridge-induced translocation (BIT) by targeted DNA integration in yeast. Chromosoma 114:15-27
30. Umezu K, Hiraoka M, Mori M, Maki H (2002) Structural analysis of aberrant chromosomes that occur spontaneously in diploid Saccharomyces cerevisiae: Retrotransposon Ty1 plays a crucial role in chromosomal rearrangements. Genetics 160:97-110
31. Wach A, Brachat A, Pohlmann R, Philippsen P (1999) New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 410:1793-1808
32. Waghmare SK, Bruschi CV (2005) Differential chromosome control of ploidy in the yeast Saccharomyces cerevisiae. Yeast 22:625-639
33. Waghmare SK, Caputo V, Radovic S, Bruschi CV (2003) Specific targeted integration of kanamycin resistance-associated non-selectable DNA in the genome of the yeast Saccharomyces cerevisiae. Biotechniques 34:1024-1028
34. Wiese C, Gauny SS, Liu WC, Cherbonnel-Lasserre CL, Kronenberg A (2001) Different mechanisms of radiation-induced loss of heterozygosity in two human lymphoid cell lines from a single donor. Cancer Res 61:1129-1137
35. Wijnhoven SW, Sonneveld E, Kool HJ, van Teijlingen CM, Vrieling H (2003) Chemical carcinogens induce varying patterns of LOH in mouse T-lymphocytes. Carcinogenesis 24:139-144
36. Zang Y, Garrè M, Gjuracic K, Bruschi CV (2002) Chromosome V loss due to centromere knockout or MAD2 deletion is immediately followed by restitution of homozygous diploidy in Saccharomyces cerevisiae. Yeast 19:553-564