Cell-based therapy facilitates venous thrombus resolution

Thrombosis and Haemostasis

Volumn 101, Issue 3, 2009, Pages 460-464

  Santo, Stefano Di ^a   Tapper, Oren M ^b   Von Ballmoos, Moritz Wyler ^a   Diehm, Nicolas ^a   Völzmann, Jan ^a   Baumgartner, Iris ^a   Kalka, Christoph ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

Cell therapy; Endothelial progenitor cells; Macrophages; Neovascularisation; Venous thrombosis

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CELL THERAPY; CONTROLLED STUDY; HEALING; IMMUNOHISTOCHEMISTRY; INFERIOR CAVA VEIN; LASER DOPPLER FLOWMETRY; MACROPHAGE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RAT; RECANALIZATION; STEM CELL; VEIN THROMBOSIS;

ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, NUDE; STEM CELL TRANSPLANTATION; TISSUE THERAPY; VENOUS THROMBOSIS;

EID: 62549108670     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH08-07-0453     Document Type: Article

References (22)

1. Modarai B, Burnand KG, Humphries I et al. The role of neovaseularisation in the resolution of venous thrombus. Thromb Haemost 2005; 93; 801-809.
2. Modarai B, Bumand KG, Sawyer B, et al. Endothelial progenitor cells are recruited into resolving venous thrombi. Circulation 2005; 111: 2645-2653.
3. Moldovan NI. Role of monocytes and macrophages in adult angiogenesis: a light at the tunnel's end. J Hematotherap Stem Cell Res 2002; 11: 179-194.
4. Rafii S, Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med 2003; 9: 702-712.
5. Kamihata H, Matsubara H, Nishiue T, et al. Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines. Circulation 2001; 104: 1046-1052.
6. Kawamoto A, Gwon HC, Iwaguro H, et al. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation 2001; 103: 634-637.
7. Zhang ZG, Zhang L, Jiang Q, et al. Bone marrowderived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse. Circulation Res 2002; 90: 284-288.
8. Kalka C, Masuda H, Takahashi T, et al. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovaseularisation. Proc Natl Acad Sci USA 2000; 97: 3422-3427.
9. Wakefield TW, Tinn MJ, Henke PK, et al. Neovascularization during venous thrombosis organization: a preliminary study. J Vasc Surg 1999; 30: 885-892.
10. van Ramshorst B, van Bemmelen PS, Hoeneveld H, et al. Thrombus regression in deep venous thrombosis. Quantification of spontaneous thrombolysis with duplex scanning, Circulation 1992; 86: 414-419.
11. Hirano K, Shimono T, Imanaka-Yoshida K, et al. Method of cell transplantation promoting the organization of intraarterial thrombus. Circulation 2005; 112: I111-116.
12. Moldovan NI. Tissular insemination of progenitor endothelial cells: the problem, and a suggested solution. Adv Exp Med Biol 2003; 522: 99-113.
13. Wakefield TW, Myers DD, Henke PK. Mechanisms of venous thrombosis and resolution. Arterioscler Thromb Vasc Biol 2008; 28: 387-391.
14. Varma MR, Moaveni DM, Dewyer NA, et al. Deep vein thrombosis resolution is not accelerated with increased neovaseularisation. J Vasc Surg 2004; 40: 536-542.
15. Humphries J, McGuinness CL, Smith A, et al. Monocyte chemotactic protein-1 (MCP-1) accelerates the organization and resolution of venous thrombi. J Vasc Surg 1999; 30: 894-899.
16. Ali T, Humphries J, Burnand K, et al. Monocyte recruitment in venous thrombus resolution. J Vasc Surg 2006; 43: 601-608.
17. Henke PK, Varma MR, Deatrick KB, et al. Neutrophils modulate post-thrombotic vein wall remodeling but not thrombus neovaseularisation. Thromb Haemost 2006; 95: 272-281.
18. Waltham M, Burnand KG, Collins M, et al. Vascular endothelial growth factor and basic fibroblast growth factor are found in resolving venous thrombi. J Vasc Surg 2000; 32: 988-996.
19. Henke PK, Varga A, De S, et al. Deep vein thrombosis resolution is modulated by monocyte CXCR2-mediated activity in a mouse model. Arterioscler Thromb Vasc Biol 2004; 24: 1130-1137.
20. Henke PK, Wakefield TW, Kadell AM, et al. Interleukin-8 administration enhances venous thrombosis resolution in a rat model. J Surg Res 2001; 99: 84-91.
21. Waltham M, Burnand KG, Collins M, et al. Vascular endothelial growth factor enhances venous thrombus recanalisation and organisation. Thromb Haemost 2003; 89: 169-176.
22. Urbich C, Aicher A, Heeschen C, et al. Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. J Mol Cell Cardiol 2005; 39: 733-742.