Pancreatic imaging with 11C-dihydrotetrabenazine PET: A perspective

Journal of Nuclear Medicine

Volumn 50, Issue 3, 2009, Pages 335-337

  Fagan, Shawn P ^a   Fischman, Alan J ^a  

^a SHRINERS HOSPITALS FOR CHILDREN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CARBOMETHOXY 3 (4 FLUOROPHENYL)TROPANE C 11; 2BETA CARBOMETHOXY 3BETA (4 FLUOROPHENYL) N (1 IODOPROP 1 EN 3 YL)NORTROPANE C 11; 2BETA CARBOMETHOXY 3BETA (4 FLUOROPHENYL) N (1 IODOPROP 1 EN 3 YL)NORTROPANE I 131; 6 FLUORODOPA F 18; ALTROPANE; AROMATIC LEVO AMINO ACID DECARBOXYLASE; CARBON 11; DIHYDROTETRABENAZINE; DIHYDROTETRABENAZINE C 11; METHYLPHENIDATE; METHYLPHENIDATE C 11; TROPANE DERIVATIVE; UNCLASSIFIED DRUG; VESICULAR MONOAMINE TRANSPORTER 2; CARBON; DIAGNOSTIC AGENT; DRUG DERIVATIVE; RADIOPHARMACEUTICAL AGENT; TETRABENAZINE;

ARTICLE; DIABETES MELLITUS; DIAGNOSTIC IMAGING; DRUG UPTAKE; HUMAN; IMAGE ANALYSIS; NONHUMAN; PANCREAS FUNCTION; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN FUNCTION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; INSULIN DEPENDENT DIABETES MELLITUS; METHODOLOGY; NOTE; PANCREAS; SCINTISCANNING;

CARBON RADIOISOTOPES; DIABETES MELLITUS, TYPE 1; HUMANS; PANCREAS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; TETRABENAZINE;

EID: 62449326840     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.108.059568     Document Type: Article

References (22)

1. 18F]-dopa-PET imaging in assessing movement disorders. Radiol Clin North Am. 2005;43:93-106.
2. Madras BK, Elmaleh DR, Meltzer PC, Liang AY Brownell GL, Brownell AL. Positron emission tomography of cocaine binding sites on the dopamine transporter. N1DA Res Monogr. 1995:138: 57-69.
3. Volkow ND, Fowler JS, Ding YS, Wang GJ, Gatley SJ. Positron emission tomography radioligands for dopamine transporters and studies in human and nonhuman primates. Adv Pharmacol 1998;42:211-214.
4. Fischman AJ, Bonab AA, Babich JW, et al. l"C, 127I] allropane:a highly selective ligand for PET imaging of dopamine transporter sites. Synapse 2001:39:332-342.
5. Frey KA, Koeppe RA. Kilbourn MR. el al Presynaptic monoaminergic vesicles in Parkinson's disease and norma] aging. Ann Neurol. 1996:40: 873-884.
6. Ding YS, Fowler JS. Volkow ND, et al. Carbon-11-d-threo-methylphenidate binding to dopamine transporter in baboon brain. J Nucl Med. 1995; 36:2298-2305.
7. Kazumata K, Dhawan V, Chaly T, et al. Dopamine transporter imaging with fluorine-18-FPCIT and PET. J Nucl Med. 1998;39:1521-1530.
8. Gilman S, Frey KA, Koeppe RA, et al. Decreased striatal monoaminergic terminals in olivopontocerebellar atrophy and multiple system atrophy demonstrated with positron emission tomography Ann Neurol. 1996;40:885-892.
9. Lee CS, Samii A, Sossi V, et al. In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease. Ann Neurol 2000; 47:493-503.
10. 18F-fluoro-L-DOPA. J Nucl Med. 2005;46:560-566.
11. 18F]ftuoro-L-dihydroxyphenylalanine (DOPA) positron emission tomography and immunohistochemistry study of DOPA decarboxylase and insulin secretion. J Clin Endocrinol Metab 2006;91:933-940.
12. 18F]fluoro-L-DOPA PET in the diagnosis of hyperinsulinism of infancy. Endocr Dev. 2007:12: 55-66.
13. l8F-fluoro-L-DOPA PET-CT imaging combined with genetic analysis for optimal classification and treatment in a child with severe congenital hyperinsulinism. An Pediatr (Barc) 2008;68:48l-485.
14. Souza F, Freeby M, Hultman K, et al. Current progress in non-invasive imaging of beta cell mass of the endocrine pancreas. Curr Med Chem 2006;13:2761-2773.
15. 18F]-DOPA positron emission tomography. Diabetes, 2006;55:13-18.
16. Sweet IR, Cook DL, Lernmark A, et al. Noninvasive imaging of beta cell mass: a quantitative analysis. Diabetes Technol Ther 2004;6:652-659.
17. 18F-DOPA-PET (PET/CT) in congenital hyperinsulinism. Horm Res. 2006;66:40-42.
18. 18F-fIuorodopa PET scan. J Pediatr. 2007:150:140-145.
19. 11C]DTBZ. Nucl Med Biol 2006;33:855-864.
20. Souza F, Simpson N, Raffo A, et al. Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model. J Clin Invest 2006;116:1506-1513.
21. 11C]- dihydrotetrabenazine imaging of baboons: biodistribution and human radiation dosimetry estimates. Eur J Nucl Med Mol Imaging. 2008;35:790-797.
22. 11C-dihydrotetrabenazine PET of the pancreas in subjects with longstanding type l diabetes and in healthy controls. J Nucl Med. 2009;50:382-389.