Intrinsic fluorescence spectroscopy for endoscopic detection and localization of the endobronchial cancerous lesions

Journal of Biomedical Optics

Volumn 13, Issue 6, 2008, Pages

  Fawzy, Yasser ^a,b   Zeng, Haishan ^c  

^a Perceptronix Medical Inc   (Canada)

^b Cairo University   (Egypt)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

Cancer detection; Fluorescence spectroscopy; Lung cancer; Reflectance spectroscopy; Tissue fluorophores; Tissue optics

Indexed keywords

CANCER DETECTION; CANCEROUS LESIONS; CLASSIFICATION ANALYSIS; DETECTION AND LOCALIZATION; DETECTION SENSITIVITY; DIAGNOSTIC INFORMATION; DIAGNOSTIC POTENTIAL; FLUORESCENCE SPECTRA; FLUORESCENCE SPECTROSCOPY AND IMAGING; IN-VIVO; INTRINSIC FLUORESCENCE; LUNG CANCER; PRINCIPLE COMPONENT; REFLECTANCE SPECTROSCOPY; REFLECTANCE SPECTRUM; SENSITIVITY AND SPECIFICITY; SPECTRAL MEASUREMENT; TISSUE OPTICAL PROPERTIES; TISSUE OPTICS;

BIOLOGICAL ORGANS; DISEASES; ENDOSCOPY; FLUORESCENCE; FLUORESCENCE SPECTROSCOPY; OPTICAL PROPERTIES; PRINCIPAL COMPONENT ANALYSIS; REFLECTION; SPECTRUM ANALYSIS; TISSUE;

FLUOROPHORES;

ALGORITHM; ARTICLE; AUTOMATED PATTERN RECOGNITION; BRONCHOSCOPY; BRONCHUS TUMOR; COMPUTER ASSISTED DIAGNOSIS; EVALUATION; FLUORESCENCE MICROSCOPY; HUMAN; IMAGE ENHANCEMENT; METHODOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPECTROFLUOROMETRY;

ALGORITHMS; BRONCHIAL NEOPLASMS; BRONCHOSCOPY; HUMANS; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MICROSCOPY, FLUORESCENCE; PATTERN RECOGNITION, AUTOMATED; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE;

EID: 62449298065     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3041704     Document Type: Article

References (33)

1. S. Lam, J. Y. C. Hung, S. M. Kennedy, J. C. Leriche, S. Vedal, B. Nelems, C. E. MacAulay, and B. Paclic, "Detection of dysplasia and carcinoma in situ by ratio fluorometry", Am. Rev. Respir. Dis. 146, 1458-1461 (1992).
2. S. Lam, T. Kennedy, M. Unger, Y. E. Miller, D. Gelmont, V. Rusch, B. Gipe, D. Howard, J. C. LeRiche, A. Coldman, and A. F. Gazdar, "Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy", Chest 113, 696-702 (1998). (Pubitemid 28130944)
3. N. Ramanujam, M. Mitchell, A. Mahadevan, S. Thomsen, E. Silva, and R. Richards-Kortum, "Fluorescence spectroscopy: a diagnostic tool for cervical intraepithelial neoplasia (CIN)", Gynecol. Oncol. 52, 31-38 (1994). (Pubitemid 24066849)
4. G. Wagnieres, W. Star, and B. Wilson, "In vivo fluorescence spectroscopy and imaging for oncological applications", Photochem. Photobiol. 68, 603-632 (1998). (Pubitemid 128472287)
5. Y. Kusunoki, F. Imamura, and H. Uda, "Early detection of lung cancer with laser-induced fluorescence endoscopy and spectrofluorometry", Chest 118, 1776-1782 (2000). (Pubitemid 32001809)
6. M. Keijzer, R. R. Kortum, S. L. Jacques, and M. S. Feld, "Fluorescence spectroscopy of turbid media: Autofluorescence of the human aorta", Appl. Opt. 28, 4286-4292 (1989).
7. A. J. Durkin, S. Jaikumar, N. Ramanujam, and R. R. Kortum, "Relation between fluorescence spectra of dilute and turbid samples", Appl. Opt. 33, 414-423 (1994).
8. J. Wu, M. S. Feld, and R. P. Rava, "Analytical model for extracting intrinsic fluorescence in turbid media", Appl. Opt. 32, 3585-3595 (1993).
9. M. G. Muller, I. Georgakoudi, Q. Zhang, J. Wu, and M. Feld, "Intrinsic fluorescence spectroscopy in turbid media: disentangling effects of scattering and absorption", Appl. Opt. 40, 4633-4646 (2000).
10. Q. Zhang, M. G. Muller, J. Wu, and M. S. Feld, "Turbidity-free fluorescence spectroscopy of biological tissue", Opt. Lett. 25, 1451-1453 (2000).
11. N. C. Biswal, S. Gupta, and N. Ghosh, "Recovery of turbidity free fluorescence from measured fluorescence: an experimental approach", Opt. Express 11, 3320-3331 (2003).
12. J. C. Finlay and T. H. Foster, "Recovery of hemoglobin oxygen saturation and intrinsic fluorescence with a forward-adjoint model", Appl. Opt. 44, 1917-1933 (2005). (Pubitemid 40479543)
13. H. Zeng, M. Petek, M. T. Zorman, A. McWilliams, B. Paclic, and S. Lam, "Integrated endoscopy system for simultaneous imaging and spectroscopy for early lung cancer detection", Opt. Lett. 29, 587-589 (2004).
14. M. Tercelj, H. Zeng, and B. Palcic, "Acquisition of fluorescence and reflectance spectra during routine bronchoscopy examinations using the ClearVu Elite device: Pilot study", Lung Cancer 50, 35-42 (2005). (Pubitemid 41297467)
15. J. Hung, S. Lam, J. LeRiche, and B. Palcic, "Autofluorescence of normal and malignant bronchial tissue", Lasers Surg. Med. 11, 99-105 (1991).
16. J. M. Schmitt and G. Kumar, "Optical scattering properties of soft tissue: a discrete particle model", Appl. Opt. 37, 2788-2797 (1998). (Pubitemid 128657591)
17. Y. Fawzy, M. Petek, M. Zorman, and H. Zeng, "In-vivo assessment and evaluation of lung tissue morphologic and physiological changes from non-contact endoscopic reflectance spectroscopy for improving lung cancer detection", J. Biomed. Opt. 4, 044003-12 (2006).
18. M. P. L. Bard, A. Amelink, V. N. Hegt, W. J. Graveland, H. J. C. M. Sterenborg, H. C. Hoogsteden, and J. G. J. V. Aerts, "Measurement of Hypoxia-related parameters in bronchial mucosa by use of optical spectroscopy", Am. J. Respir. Crit. Care Med. 171, 1178-1184 (2005). (Pubitemid 40663732)
19. Y. Fawzy and H. Zeng, "Determination of scattering volume fraction and particle size-distribution in the superficial layer of a turbid medium using diffuse reflectance spectroscopy", J. Appl. Opt 16, 3902-3912 (2006). (Pubitemid 44072980)
20. E. Brambilla, W. D. Travis, T. V. Colby et al., "The new World Health Association Classification of lung cancer", Eur. Respir. J. 18, 1059-1068 (2000).
21. R. W. Dillion and M. Goldstein, Multivariate Analysis: Methods and Applications, Wiley, New York (1984).
22. P. Lachenbruch and R. M. Mickey, "Estimation of error rates in discriminate analysis", Technometrics 10, 1-11 (1968).
23. I. Georgakoudi, E. Sheets, M. Muller, V. Backman, C. Crum, K. Badizadegan, R. Dasari, and M. Feld, "Trimodal spectroscopy for the detection and characterization of cervical precancers in vivo", Am. J. Obstet. Gynecol. 186, 374-382 (2002). (Pubitemid 34234144)
24. R. Drezek, K. Sokolov, U. Utzinger, I. Boiko, A. Malpica, M. Follen, and R. Richards-Kortum, "Understanding the contributions of NADH and collagen to cervical tissue fluorescence spectra: Modeling, measurements, and implications", J. Biomed. Opt. 6(4), 385-396 (2001). (Pubitemid 34220957)
25. M. Muller, I. Georgakoudi, Q. Zhang, J. Wu, and M. Feld, "Intrinsic fluorescence spectroscopy in turbid media: disentangling effects of scattering and absorption", Appl. Opt. 40, 4633-4646 (2001).
26. R. Gillies, G. Zonios, R. R. Anderson, and N. Kollias, "Fluorescence excitation spectroscopy provides information about human skin in vivo", J. Invest. Dermatol. 115(suppl 4), 704-707 (2000).
27. H. Zeng and C. MacAulay, "Fluorescence spectroscopy and imaging for skin cancer detection and evaluation", in Handbook of Biomedical Fluorescence, M. A. Mycek and B. W. Pogue, Eds., pp. 315-360, Marcel Dekker, New York (2003).
28. I. Georgakoudi, E. Sheets, M. Muller, V. Backman, C. Crum, K. Badizadegan, R. Dasari, and M. Feld, "Trimodal spectroscopy for the detection and characterization of cervical precancers in vivo", Am. J. Obstet. Gynecol. 186, 374-381 (2001).
29. S. Chang, Y. Mirabal, E. Atkinson, D. Cox, A. Malpica, M. Follen, and R. Kortum, "Combined reflectance and fluorescence spectroscopy for detection of cervical pre-cancer", J. Biomed. Opt. 10(2), 024031 (2005).
30. S. Chang, N. Marin, M. Follen, and R. Kortum, "Model-based analysis of clinical fluorescence spectroscopy for in vivo detection of cervical intraepithelial dysplasia", J. Biomed. Opt. 11(2), 024008 (2006).
31. J. Qu, C. MacAulay, S. Lam, and B. Palcic, "Laser-induced fluorescence spectroscopy at endoscopy: tissue optics, Monte Carlo modeling, and in vivo measurements", Opt. Eng. 34, 3334-3343 (1995).
32. D. Goujon, M. Zellweger, A. Radu, P. Grojean, B. Weber, H. Bergh, P. Monnier, and G. Wagnieres, "In vivo autofluorescence imaging of early cancers in the human tracheobronchial tree with a spectrally optimized system", J. Biomed. Opt. 8, 17-25 (2003).
33. M. Bard, A. Amelink, M. Skurichina, M. Bakker, S. Burgers, J. Meerbeck, R. Duin, J. Aerts, H. Hoogsteden, and H. Sterenborg, "Improving the specificity of fluorescence bronchoscopy for the analysis of neoplastic lesions of the bronchial tree by combination with optical spectroscopy: Preliminary communication", Lung Cancer 47, 41-47 (2005). (Pubitemid 39643240)