Ubiquitin-binding motif of human DNA polymerase ν is required for correct localization

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 8, 2009, Pages

  Sabbioneda, Simone ^a   Green, Catherine M ^b   Bienko, Marzena ^c   Kannouche, Patricia ^d   Dikic, Ivan ^c   Lehmann, Alan R ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c GOETHE UNIVERSITY MEDICAL SCHOOL   (Germany)

^d CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DNA DIRECTED DNA POLYMERASE ETA; DNA POLYMERASE; UBIQUITIN;

BINDING AFFINITY; BINDING SITE; CELL NUCLEUS; DNA REPLICATION; DNA TRANSFECTION; GENE MUTATION; HUMAN; LETTER; MOLECULAR DYNAMICS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SPECIES; UBIQUITINATION;

BINDING SITES; DNA-DIRECTED DNA POLYMERASE; GREEN FLUORESCENT PROTEINS; HUMANS; MUTATION; PROLIFERATING CELL NUCLEAR ANTIGEN; UBIQUITIN;

EID: 62449259799     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0812744106     Document Type: Letter

References (5)

1. Acharya N, et al. (2008) Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase eta in translesion DNA synthesis. Proc Natl Acad Sci USA 105:17724-17729.
2. Bienko M, et al. (2005) Ubiquitin-binding domains in translesion synthesis polymerases. Science 310:1821-1824.
3. Plosky BS, et al. (2006) Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitin. Embo J 25:2847-2855.
4. Sabbioneda S, et al. (2008) Effect of proliferating cell nuclear antigen ubiquitination and chromatin structure on the dynamic properties of the Y-family DNA polymerases. Mol Biol Cell 19:5193-5202.
5. Crosetto N, et al. c17 (2008) Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner. J Biol Chem 283:35173-35185.