Base invaders. Coupling experiments and multiscale modeling of dendrimer-based siRNA delivery agents

CIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Biomedical Applications of Smart Materials, Nanotechnology and Micro/Nano Engineering

Volumn 57, Issue , 2008, Pages 154-159

  Posocco, Paola ^a,b   Pavan, Giovanni Maria ^a,b   Scocchi, Giulio ^a,b   Handgraaf, Jan Willem ^c   Malek, Anastasia ^d   Maly, Marek ^b,e,f   Fermeglia, Maurizio ^a   Fraaije, Johannes G E M ^c,g   Catapano, Carlo V ^d   Danani, Andrea ^b   Pricl, Sabrina ^a,b  

^a UNIVERSITY OF TRIESTE   (Italy)

^b UNIVERSITY OF APPLIED SCIENCES AND ARTS OF SOUTHERN SWITZERLAND   (Switzerland)

^c Culgi BV   (Netherlands)

^d ONCOLOGY INSTITUTE OF SOUTHERN SWITZERLAND   (Switzerland)

^e J E PURKINJE UNIVERSITY   (Czech Republic)

^f INSTITUTE OF CHEMICAL PROCESS FUNDAMENTALS   (Czech Republic)

^g LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Dendrimers; Multiscale molecular modeling; Nanovectors; Self assembly; SiRNA therapeutics

Indexed keywords

DENDRIMERS; INTELLIGENT MATERIALS; MEDICAL APPLICATIONS; MOLECULAR MODELING; NANOTECHNOLOGY; OLIGONUCLEOTIDES; RNA; SELF ASSEMBLY;

EXPERIMENTAL APPROACHES; EXPERIMENTAL TECHNIQUES; MOLECULAR PARAMETERS; MULTI-SCALE MODELING; MULTI-SCALE MOLECULAR MODELING; NANOVECTORS; SIRNA THERAPEUTICS; TECHNOLOGICAL PLATFORM;

FUNCTIONAL POLYMERS;

EID: 62449185078     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.4028/www.scientific.net/AST.57.154     Document Type: Conference Paper

References (12)

1. S.M. Hammond, A.A. Caudy and G.J. Hammond: Nat. Rev. Gen. Vol. 2 (2001), p.110.
2. P.M. Waterhouse, M.B. Wang and T. Lough: Nature Vol. 411 (2001), p. 834.
3. A. Fire, S. Xu, M.K. Montgomery, S.A: Kostas, S.E. Driver and C.C. Mello: Nature Vol. 391 (1998), p.806.
4. N.J. Caplen, S. Parrish, F. Imani, A. Fire and R.A. Morgan: Proc. Natl. Acad. Sci. USA Vol. 98 (2001), p. 9742.
5. P.E. Nielsen: Gene Ther. Vol. 12 (2005), p. 956.
6. J.H. Jeong, S.W. Kim and T.G. Park: Progr. Polym. Sci. Vol. 32 (2007), p. 1239.
7. D.A. Case, T.A. Darden, T.E. Cheatham, III, C.L. Simmerling, J. Wang, R.E. Duke, R. Luo, K.M. Merz, D.A. Pearlman, M. Crowley, R.C. Walker, W. Zhang, B. Wang, S. Hayik, A. Roitberg, G. Seabra, K.F. Wong, F. Paesani, X. Wu, S. Brozell, V. Tsui, H. Gohlke, L. Yang, C. Tan, J. Mongan, V. Hornak, G. Cui, P. Beroza, D.H. Mathews, C. Schafmeister, W.S. Ross, and P.A. Kollman (2006), AMBER 9, University of California, San Francisco, CA, USA.
8. J. Srinivasan, T.E. Cheatham III, P. Cieplak, P.A. Kollman, and D.A. Case: J. Am. Chem. Soc. Vol. 120 (1998), p. 9401.
9. P. Posocco, G. Scocchi, A. Danani, J.-W. Handgraaf, J.G.E.M. Fraaije, M. Fermeglia, and S. Pricl: J. Am. Chem. Soc. submitted (2008).
10. A.V. Kyrylyuk, F.H. Case, and J.G.E.M. Fraaije: QSAR Comb. Sci. Vol. 24 (2005), p. 131.
11. The Chemistry Unified Language Interface (Culgi), version 2.2.0, Culgi B.V., The Netherlands 2007.
12. B. Wang, X. Zhang, X. Jia, Z. Li, Y. Ji, L. Yang, and Y. Wei: J. Am. Chem. Soc. Vol. 126 (2004), p. 15180.