Spontaneous baroreflex measures are unable to detect age-related impairments in cardiac baroreflex function during dynamic exercise in humans

Experimental Physiology

Volumn 94, Issue 4, 2009, Pages 447-458

  Fisher, James P ^a,c,f   Ogoh, Shigehiko ^d   Junor, Chelif ^a   Khaja, Azamuddin ^a   Northrup, Mindy ^a   Fadel, Paul J ^a,b,c,e  

^a University of Missouri   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^e UNIVERSITY OF MISSOURI   (United States)

^f UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BLOOD PRESSURE; CAROTID SINUS PRESSORECEPTOR REFLEX; COMPARATIVE STUDY; CONTROLLED STUDY; DYNAMIC EXERCISE; FEMALE; HEART RATE; HUMAN; MALE; NORMAL HUMAN; PRESSORECEPTOR REFLEX; SENSITIVITY ANALYSIS; STEADY STATE;

EID: 62449095179     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2008.044867     Document Type: Article

References (55)

1. Borg GA (1982). Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14, 377 381.
2. Brodde OE, Konschak U, Becker K, Ruter F, Poller U, Jakubetz J, Radke J Zerkowski HR (1998). Cardiac muscarinic receptors decrease with age. In vitro and in vivo studies. J Clin Invest 101, 471 478.
3. Cameron JD, Stevenson I, Reed E, McGrath BP, Dart AM Kingwell BA (2004). Accuracy of automated auscultatory blood pressure measurement during supine exercise and treadmill stress electrocardiogram-testing. Blood Press Monit 9, 269 275.
4. Carrington CA White MJ (2002). Spontaneous baroreflex sensitivity in young and older people during voluntary and electrically evoked isometric exercise. Age Ageing 31, 359 364.
5. Chapleau MW, Cunningham JT, Sullivan MJ, Wachtel RE Abboud FM (1995). Structural versus functional modulation of the arterial baroreflex. Hypertension 26, 341 347.
6. Colombo R, Mazzuero G, Spinatonda G, Lanfranchi P, Giannuzzi P, Ponikowski P, Coats AJ Minuco G (1999). Comparison between spectral analysis and the phenylephrine method for the assessment of baroreflex sensitivity in chronic heart failure. Clin Sci 97, 503 513.
7. Diaz T Taylor JA (2006). Probing the arterial baroreflex: is there a 'spontaneous' baroreflex Clin Auton Res 16, 256 261.
8. Dietrich A, Riese H, van Roon AM, van Engelen K, Ormel J, Neeleman J Rosmalen JG (2006). Spontaneous baroreflex sensitivity in (pre)adolescents. J Hypertens 24, 345 352.
9. Donders AR, Van Der Heijden GJ, Stijnen T Moons KG (2006). Review: a gentle introduction to imputation of missing values. J Clin Epidemiol 59, 1087 1091.
10. Ebert TJ, Morgan BJ, Barney JA, Denahan T Smith JJ (1992). Effects of aging on baroreflex regulation of sympathetic activity in humans. Am J Physiol Heart Circ Physiol 263, H798 H803.
11. Eckberg DL, Kifle YT Roberts VL (1980). Phase relationship between normal human respiration and baroreflex responsiveness. J Physiol 304, 489 502.
12. Fadel PJ, Ogoh S, Keller DM Raven PB (2003). Recent insights into carotid baroreflex function in humans using the variable pressure neck chamber. Exp Physiol 88, 671 680.
13. Fadel PJ, Ogoh S, Watenpaugh DE, Wasmund W, Olivencia-Yurvati A, Smith ML Raven PB (2001). Carotid baroreflex regulation of sympathetic nerve activity during dynamic exercise in humans. Am J Physiol Heart Circ Physiol 280, H1383 H1390.
14. Fisher JP, Ogoh S, Ahmed A, Aro MR, Gute D Fadel PJ (2007). Influence of age on cardiac baroreflex function during dynamic exercise in humans. Am J Physiol Heart Circ Physiol 293, H777 H783.
15. Fletcher GF, Balady GJ, Amsterdam EA, Chaitman B, Eckel R, Fleg J, Froelicher VF, Leon AS, Pina IL, Rodney R, Simons-Morton DA, Williams MA Bazzarre T (2001). Exercise standards for testing and training: a statement for healthcare professionals from the American Heart Association. Circulation 104, 1694 1740.
16. Gribbin B, Pickering TG, Sleight P Peto R (1971). Effect of age and high blood pressure on baroreflex sensitivity in man. Circ Res 29, 424 431.
17. Grundy SM, Benjamin IJ, Burke GL, Chait A, Eckel RH, Howard BV, Mitch W, Smith SC Jr. Sowers JR (1999). Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation 100, 1134 1146.
18. Hunt BE, Farquhar WB Taylor JA (2001). Does reduced vascular stiffening fully explain preserved cardiovagal baroreflex function in older, physically active men Circulation 103, 2424 2427.
19. Iellamo F (2001). Neural mechanisms of cardiovascular regulation during exercise. Auton Neurosci 90, 66 75.
20. Iellamo F, Galante A, Legramante JM, Lippi ME, Condoluci C, Albertini G Volterrani M (2005). Altered autonomic cardiac regulation in individuals with Down syndrome. Am J Physiol Heart Circ Physiol 289, H2387 H2391.
21. Iellamo F, Legramante JM, Raimondi G Peruzzi G (1997). Baroreflex control of sinus node during dynamic exercise in humans: effects of central command and muscle reflexes. Am J Physiol Heart Circ Physiol 272, H1157 H1164.
22. Iwasaki K, Zhang R, Perhonen MA, Zuckerman JH Levine BD (2004). Reduced baroreflex control of heart period after bed rest is normalized by acute plasma volume restoration. Am J Physiol Regul Integr Comp Physiol 287, R1256 R1262.
23. Kent BB, Drane JW, Blumenstein B Manning JW (1972). A mathematical model to assess changes in the baroreceptor reflex. Cardiology 57, 295 310.
24. La Rovere MT, Bigger JT Jr., Marcus FI, Mortara A Schwartz PJ (1998). Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators. Lancet 351, 478 484.
25. La Rovere MT, Pinna GD, Hohnloser SH, Marcus FI, Mortara A, Nohara R, Bigger JT Jr., Camm AJ Schwartz PJ (2001). Baroreflex sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmias: implications for clinical trials. Circulation 103, 2072 2077.
26. La Rovere MT, Pinna GD Raczak G (2008). Baroreflex sensitivity: measurement and clinical implications. Ann Noninvasive Electrocardiol 13, 191 207.
27. Lipman RD, Salisbury JK Taylor JA (2003). Spontaneous indices are inconsistent with arterial baroreflex gain. Hypertension 42, 481 487.
28. Lucini D, Cerchiello M Pagani M (2004). Selective reductions of cardiac autonomic responses to light bicycle exercise with aging in healthy humans. Auton Neurosci 110, 55 63.
29. McDowall LM Dampney RA (2006). Calculation of threshold and saturation points of sigmoidal baroreflex function curves. Am J Physiol Heart Circ Physiol 291, H2003 H2007.
30. Malliani A, Pagani M, Lombardi F Cerutti S (1991). Cardiovascular neural regulation explored in the frequency domain. Circulation 84, 482 492.
31. Matsukawa T, Sugiyama Y Mano T (1996). Age-related changes in baroreflex control of heart rate and sympathetic nerve activity in healthy humans. J Auton Nerv Syst 60, 209 212.
32. Mazzeo R, Cavanagh P, Evans WJ, Fiatarone M, Hagberg J, McAuley E Startzell J (1998). American College of Sports Medicine Position Stand. Exercise and physical activity for older adults. Med Sci Sports Exerc 30, 992 1008.
33. Monahan KD, Dinenno FA, Seals DR, Clevenger CM, Desouza CA Tanaka H (2001). Age-associated changes in cardiovagal baroreflex sensitivity are related to central arterial compliance. Am J Physiol Heart Circ Physiol 281, H284 H289.
34. Mortara A, La Rovere MT, Pinna GD, Prpa A, Maestri R, Febo O, Pozzoli M, Opasich C Tavazzi L (1997). Arterial baroreflex modulation of heart rate in chronic heart failure: clinical and hemodynamic correlates and prognostic implications. Circulation 96, 3450 3458.
35. Ogoh S, Fadel PJ, Monteiro F, Wasmund WL Raven PB (2002). Haemodynamic changes during neck pressure and suction in seated and supine positions. J Physiol 540, 707 716.
36. Ogoh S, Fadel PJ, Nissen P, Jans O, Selmer C, Secher NH Raven PB (2003). Baroreflex-mediated changes in cardiac output and vascular conductance in response to alterations in carotid sinus pressure during exercise in humans. J Physiol 550, 317 324.
37. Ogoh S, Fisher JP, Dawson EA, White MJ, Secher NH Raven PB (2005). Autonomic nervous system influence on arterial baroreflex control of heart rate during exercise in humans. J Physiol 566, 599 611.
38. O'Leary DS (1996). Heart rate control during exercise by baroreceptors and skeletal muscle afferents. Med Sci Sports Exerc 28, 210 217.
39. Pagani M, Malfatto G, Pierini S, Casati R, Masu AM, Poli M, Guzzetti S, Lombardi F, Cerutti S Malliani A (1988). Spectral analysis of heart rate variability in the assessment of autonomic diabetic neuropathy. J Auton Nerv Syst 23, 143 153.
40. Parati G, Di Rienzo M Mancia G (2000). How to measure baroreflex sensitivity: from the cardiovascular laboratory to daily life. J Hypertens 18, 7 19.
41. Parati G, Di Rienzo M Mancia G (2001). Dynamic modulation of baroreflex sensitivity in health and disease. Ann N Y Acad Sci 940, 469 487.
42. Parati G, Frattola A, Di Rienzo M, Castiglioni P, Pedotti A Mancia G (1995). Effects of aging on 24-h dynamic baroreceptor control of heart rate in ambulant subjects. Am J Physiol Heart Circ Physiol 268, H1606 H1612.
43. Parati G, Mancia G, Di Rienzo M Castiglioni P (2006). Point: cardiovascular variability is/is not an index of autonomic control of circulation. J Appl Physiol 101, 676 678 discussion 681-672.
44. Parker P, Celler BG, Potter EK McCloskey DI (1984). Vagal stimulation and cardiac slowing. J Auton Nerv Syst 11, 226 231.
45. Parlow J, Viale JP, Annat G, Hughson R Quintin L (1995). Spontaneous cardiac baroreflex in humans. Comparison with drug-induced responses. Hypertension 25, 1058 1068.
46. Pitzalis MV, Mastropasqua F, Passantino A, Massari F, Ligurgo L, Forleo C, Balducci C, Lombardi F Rizzon P (1998). Comparison between noninvasive indices of baroreceptor sensitivity and the phenylephrine method in post-myocardial infarction patients. Circulation 97, 1362 1367.
47. Potts JT, Shi XR Raven PB (1993). Carotid baroreflex responsiveness during dynamic exercise in humans. Am J Physiol Heart Circ Physiol 265, H1928 H1938.
48. Raven PB, Fadel PJ Ogoh S (2006). Arterial baroreflex resetting during exercise: a current perspective. Exp Physiol 91, 37 49.
49. Rimoldi O, Furlan R, Pagani MR, Piazza S, Guazzi M, Pagani M Malliani A (1992). Analysis of neural mechanisms accompanying different intensities of dynamic exercise. Chest 101, 226S 230S.
50. Robbe HW, Mulder LJ, Ruddel H, Langewitz WA, Veldman JB Mulder G (1987). Assessment of baroreceptor reflex sensitivity by means of spectral analysis. Hypertension 10, 538 543.
51. Saul JP, Berger RD, Albrecht P, Stein SP, Chen MH Cohen RJ (1991). Transfer function analysis of the circulation: unique insights into cardiovascular regulation. Am J Physiol Heart Circ Physiol 261, H1231 H1245.
52. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (1996). Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 93, 1043 1065.
53. Taylor JA Studinger P (2006). Counterpoint: cardiovascular variability is not an index of autonomic control of the circulation. J Appl Physiol 101, 678 681 discussion 681.
54. 2 uptake kinetics during heavy exercise. Med Sci Sports Exerc 26, 1319 1326.
55. Zhang R, Iwasaki K, Zuckerman JH, Behbehani K, Crandall CG Levine BD (2002). Mechanism of blood pressure and R-R variability: insights from ganglion blockade in humans. J Physiol 543, 337 348.