Age-related changes in baroreflex control of heart rate and sympathetic nerve activity in healthy humans

Journal of the Autonomic Nervous System

Volumn 60, Issue 3, 1996, Pages 209-212

  Matsukawa, Toshiyoshi ^a   Sugiyama, Yoshiki ^a   Mano, Tadaaki ^a  

^a NAGOYA UNIVERSITY   (Japan)

Author keywords

Baroreflex; Blood pressure; Heart rate; Microneurography; Muscle sympathetic nerve activity

Indexed keywords

GLYCERYL TRINITRATE; PHENYLEPHRINE;

ADRENERGIC ACTIVITY; ADULT; AGING; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; FEMALE; HEART RATE; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; MUSCLE CONTRACTION; NERVE CONDUCTION; NORMAL HUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; VOLUNTEER;

EID: 0030581517     PISSN: 01651838     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-1838(96)00057-4     Document Type: Article

References (16)

1. [1] Cowie, M.R. and Rawles, J.M., A modified method of quantifying the carotid baroreceptor-heart rate reflex in man: the effect of age and blood pressure, Clin. Sci., 77 (1989) 223-228.
2. [2] Ebert, T.J., Morgan, B.J. Barney, J.A., Denahan, T. and Smith, J.J., Effects of aging on baroreflex regulation of sympathetic activity in humans, Am. J. Physiol., 263 (1992) H798-H803.
3. [3] Gribbin, B. and Pickering, T.G., Effect of age and high blood pressure on baroreflex sensitivity in man, Circ. Res., 29 (1971) 424-431.
4. [4] Guo, G.B., Thames, M.D. and Abboud, F.M., Arterial baroreflexes in renal hypertensive rabbits, Circ. Res., 53 (1983) 223-234.
5. [5] Iwase, S., Mano, T., Watanabe, T., Saito, M. and Kobayashi, F., Age-related changes of sympathetic outflow to muscles in humans, J. Gerontol. 46 (1991) M1-M5.
6. [6] Lindblad, L.E., Influence of age on sensitivity and effector mechanisms of the carotid baroreflex. Acta Physiol. Scand. 101 (1977) 43-49.
7. [7] Matsukawa, T., Gotoh, E., Hasegawa, O., Shionoiri, H., Tochikubo, O. and Ishii, M., Reduced baroreflex changes in muscle sympathetic nerve activity during blood pressure elevation in essential hypertension, J. Hypertens., 9 (1991) 537-542.
8. [8] Matsukawa, T., Mano, T., Gotoh, E. and Ishii, M., Elevated sympathetic nerve activity in patients with accelerated essential hypertension, J. Clin. Invest. 92 (1993) 25-28.
9. [9] Matsukawa, T., Mano, T., Gotoh, E., Minamisawa, K. and Ishii, M., Altered muscle sympathetic nerve activity in hyperthyroidism and hypothyroidism, J. Auton. Nerv. Syst., 141 (1993) 157-165.
10. [10] Pfeifer, M.A., Weinberg, C.R., Cook, D., Best, J.D., Reenan, A. and Halter, J.B., Differential changes of autonomic nervous system function with age in man, Am. J. Med. 75 (1983) 249-258.
11. [11] Pickering, T.G., Gribbin, B., Strange-Peterson, E., Cunningham, D.J.C. and Sleight, P., Effects of autonomic blockade on the baroreflex in man at rest and during exercise, Circ. Res., 30 (1972) 177-185.
12. [12] Ricksten, S.E. and Thoren, P., Reflex control of sympathetic nerve activity and heart rate from arterial baroreceptors in conscious spontaneously hypertensive rats, Clin. Sci. 61 (1981) S169-S172.
13. [13] Rowe, J.W. and Troen, B.R., Sympathetic nervous system and aging in man, Endocr. Rev., 1 (1980) 167-179.
14. [14] Shimada, K., Kitazumi, T., Sadakane, N., Ogura, H. and Ozawa, T., Age-related changes of baroreflex function, plasma norepinephrine, and blood pressure, Hypertension 7 (1985) 113-117.
15. [15] Spyer, K.M., Central nervous mechanisms contributing to cardiovascular control, J. Physiol., 474 (1994) 1-19.
16. [16] Wallin, B.G., Sundlof, F., Eriksson, B.-M., Dominiak, P., Grobecker, H. and Lindblad, L.E., Plasma noradrenaline correlates to sympathetic muscle nerve activity in normotensive man, Acta Physiol. Scand. 111 (1981) 69-73.