Genetic variations in UGT1A1 and UGT2B7 and endometrial cancer risk

Pharmacogenetics and Genomics

Volumn 19, Issue 3, 2009, Pages 239-243

  McGrath, Monica ^a,b   Lepine, Johanie ^c,d   Lee, I Min ^a,b   Villeneuve, Lyne ^c,d   Buring, Julie ^a,b   Guillemette, Chantai ^c,d   De Vivo, Immaculata ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Chaires de recherche du Canada   (Canada)

^d Université Laval   (Canada)

Author keywords

Endometrial cancer; Genetics; Polymorphisms; Uridine diphosphate glucuronosyltransferase

Indexed keywords

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER RISK; CASE CONTROL STUDY; CONTROLLED STUDY; ENDOMETRIUM CANCER; FEMALE; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HAPLOTYPE; HOMOZYGOTE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; UGT1A1 GENE; UGT2B7 GENE;

CASE-CONTROL STUDIES; COHORT STUDIES; ENDOMETRIAL NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GLUCURONOSYLTRANSFERASE; HUMANS; MIDDLE AGED;

EID: 62349136456     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e328323f66c     Document Type: Article

References (16)

1. Guillemette C. Pharmacogenomics of human UDP-glucuronosyltransferase enzymes. Pharmacogenomics J 2003; 3:136-158.
2. Zhu BT, Conney AH. Functional role of estrogen metabolism in target cells: review and perspectives. Carcinogenesis 1998; 19:1-27.
3. Cheng Z, Rios GR, King CD, Coffman BL, Green MD, Mojarrabi B, et al. Glucuronidation of catechol estrogens by expressed human UDP-glucuronosyltransferases (UGTs) 1A1, 1A3 and 2B7. Toxicol Sci 1998; 45:52-57.
4. Lepine J, Bernard O, Plante M, Tetu B, Pelletier G, Labrie F, et al. Specificity and regioselectivity of the conjugation of estradiol, estrone and their catecholestrogen and methoxyestrogen metabolites by human undine diphospho-glucuronosyltransferases expressed in endometrium. J Clin Endocrinol Metab 2004; 89:5222-5232.
5. Duguay Y, McGrath M, Lepine J, Gagne JF, Hankinson SE, Colditz GA, et al. The functional UGT1A1 promoter polymorphism decreases endometrial cancer risk. Cancer Res 2004; 64:1202-1207.
6. Bosma P, Chowdhury JR, Jansen PH. Genetic inheritance of Gilbert's syndrome. Lancet 1995; 346:314-315.
7. Guillemette C, Millikan RC, Newman B, Housman DE. Genetic polymorphisms in undine diphospho-glucuronosyltransferase 1A1 and association with breast cancer among African Americans. Cancer Res 2000; 60:950-956.
8. Innocenti F, Grimsley C, Das S, Ramirez J, Cheng C, Kuttab-Boulos H, et al. Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups. Pharmacogenetics 2002; 12:725-733.
9. Sugatani J, Yamakawa K, Yoshinari K, Machida T, Takagi H, Mori M, et al. Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia. Biochem Biophys Res Commun 2002; 292:492-497.
10. Jin C, Miners JO, Lillywhite KJ, Mackenzie PI. Complementary deoxyribonucleic acid cloning and expression of a human liver undine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs. J Pharmacol Exp Ther 1993; 264:475-479.
11. Duguay Y, Baar C, Skorpen F, Guillemette C. A novel functional polymorphism in the undine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity. Clin Pharmacol Ther 2004; 75:223-233.
12. Thibaudeau J, Lepine J, Tojcic J, Duguay Y, Pelletier G, Plante M, et al. Characterization of common UGT1A8, UGT1A9 and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone. Cancer Res 2006; 66:125-133.
13. Lampe JW, Bigler J, Bush AC, Potter JD. Prevalence of polymorphisms in the human UDP-glucuronosyltransferase 2B family: UGT2B4 (D458E), UGT2B7 (H268Y) and UGT2B15 (D85Y). Cancer Epidemiol Biomarkers Prev 2000; 9:329-333.
14. Rebbeck TR, Troxel AB, Wang Y, Walker AH, Panossian S, Gallagher S, et al. Estrogen sulfation genes, hormone replacement therapy and endometrial cancer risk. J Natl Cancer Inst 2006; 98:1311-1320.
15. Bosma PJ, Chowdhury JR, Bakker C, Gantla S, de Boer A, Oostra BA, et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med 1995; 333:1171-1175.
16. Deming SL, Zheng W, Xu WH, Cai Q, Ruan Z, Xiang YB, Shu XO. UGT1A1 genetic polymorphisms, endogenous estrogen exposure, soy food intake, and endometrial cancer risk. Cancer Epidemiol Biomarkers Prev 2008; 17:563-570.