Dextromethorphan reduces oxidative stress and inhibits atherosclerosis and neointima formation in mice

Cardiovascular Research

Volumn 82, Issue 1, 2009, Pages 161-169

  Liu, Shu Lin ^a   Li, Yi Heng ^a,b   Shi, Guey Yueh ^a,b   Tang, Sei Hui ^a,b   Jiang, Shinn Jong ^a,b   Huang, Chia Wei ^a   Liu, Ping Yen ^a,b   Hong, Jau Shyong ^c   Wu, Hua Lin ^a,b  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Anti oxidants; Atherosclerosis; Macrophages

Indexed keywords

APOLIPOPROTEIN E; DEXTROMETHORPHAN; INTERLEUKIN 10; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PLACEBO; PROTEIN KINASE C; PROTEIN P47; PROTEIN P67; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; C57BL 6 MOUSE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTIMA; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

ANIMALS; ANTIOXIDANTS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CAROTID ARTERIES; CAROTID ARTERY INJURIES; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOKINES; DEXTROMETHORPHAN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; HYPERPLASIA; LIGATION; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; NADPH OXIDASE; OXIDATIVE STRESS; PHOSPHOPROTEINS; PROTEIN KINASE C; PROTEIN TRANSPORT; SUPEROXIDES; TUNICA INTIMA;

EID: 62349119913     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp043     Document Type: Article

References (25)

1. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999;340:115-126.
2. Iiyama K, Hajra L, Iiyama M, Li H, DiChiara M, Medoff BD et al. Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Circ Res 1999;85:199-207.
3. Cathcart MK, McNally AK, Morel DW, Chisolm GM III. Superoxide anion participation in human monocyte-mediated oxidation of low-density lipoprotein and conversion of low-density lipoprotein to a cytotoxin. J Immunol 1989;142:1963-1969.
4. Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 1993;91:2546-2551.
5. Sorescu D, Weiss D, Lassegue B, Clempus RE, Szocs K, Sorescu GP et al. Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation 2002;105:1429-1435.
6. Barry-Lane PA, Patterson C, van der Merwe M, Hu Z, Holland SM, Yeh ET et al. p47phox is required for atherosclerotic lesion progression in ApoE(-/-) mice. J Clin Invest 2001;108:1513-1522.
7. Cai H, Griendling KK, Harrison DG. The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases. Trends Pharmacol Sci 2003;24:471-478.
8. Liu Y, Qin L, Li G, Zhang W, An L, Liu B et al. Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. J Pharmacol Exp Ther 2003;305:212-218.
9. Zhang W, Wang T, Qin L, Gao HM, Wilson B, Ali SF et al. Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. FASEB J 2004;18:589-591.
10. Qin L, Block ML, Liu Y, Bienstock RJ, Pei Z, Zhang W et al. Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress. FASEB J 2005;19:550-557.
11. Li G, Liu Y, Tzeng NS, Cui G, Block ML, Wilson B et al. Protective effect of dextromethorphan against endotoxic shock in mice. Biochem Pharmacol 2005;69:233-240.
12. Li G, Cui G, Tzeng NS, Wei SJ, Wang T, Block ML et al. Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage. FASEB J 2005;19:489-496.
13. Liu SL, Li YH, Shi GY, Chen YH, Huang CW, Hong JS et al. A novel inhibitory effect of naloxone on macrophage activation and atherosclerosis formation in mice. J Am Coll Cardiol 2006;48:1871-1879.
14. Kitada M, Koya D, Sugimoto T, Isono M, Araki S, Kashiwagi A et al. Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy. Diabetes 2003;52:2603-2614.
15. d'Uscio LV, Baker TA, Mantilla CB, Smith L, Weiler D, Sieck GC et al. Mechanism of endothelial dysfunction in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2001;21:1017-1022.
16. d'Uscio LV, Smith LA, Katusic ZS. Hypercholesterolemia impairs endothelium-dependent relaxations in common carotid arteries of apolipoprotein e-deficient mice. Stroke 2001;32:2658-2664.
17. Skatchkov MP, Sperling D, Hink U, Mulsch A, Harrison DG, Sindermann I et al. Validation of lucigenin as a chemiluminescent probe to monitor vascular superoxide as well as basal vascular nitric oxide production. Biochem Biophys Res Comm 1999;254:319-324.
18. Kumar A, Lindner V. Remodeling with neointima formation in the mouse carotid artery after cessation of blood flow. Arterioscler Thromb Vasc Biol 1997;17:2238-2244.
19. Roque M, Fallon JT, Badimon JJ, Zhang WX, Taubman MB, Reis ED. Mouse model of femoral artery denudation injury associated with the rapid accumulation of adhesion molecules on the luminal surface and recruitment of neutrophils. Arterioscler Thromb Vasc Biol 2000;20:335-342.
20. Babior BM. NADPH oxidase: an update. Blood 1999;93:1464- 1476.
21. Lin FY, Chen YH, Tasi JS, Chen JW, Yang TL, Wang HJ et al. Endotoxin induces toll-like receptor 4 expression in vascular smooth muscle cells via NADPH oxidase activation and mitogen-activated protein kinase signaling pathways. Arterioscler Thromb Vasc Biol 2006;26:2630- 2637.
22. Dewald B, Payne TG, Baggiolini M. Activation of NADPH oxidase of human neutrophils. Potentiation of chemotactic peptide by a diacylglycerol. Biochem Biophys Res Commun 1984;125:367-373.
23. Cathcart MK. Regulation of superoxide anion production by NADPH oxidase in monocytes/macrophages: contributions to atherosclerosis. Arterioscler Thromb Vasc Biol 2004;24:23-28.
24. Qin L, Liu Y, Wang T, Wei SJ, Block ML, Wilson B et al. NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J Biol Chem 2004;279:1415- 1421.
25. Chen Z, Keaney JF Jr, Schulz E, Levison B, Shan L, Sakuma M et al. Decreased neointimal formation in Nox2-deficient mice reveals a direct role for NADPH oxidase in the response to arterial injury. Proc Natl Acad Sci USA 2004;101:13014-13019.