On the use of protein turnover and half-lives

Neuropsychopharmacology

Volumn 34, Issue 5, 2009, Pages 1172-1173

  Kuhar, Michael J ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE; DOPAMINE; DOPAMINE RECEPTOR; NEUROTRANSMITTER; PROTEIN; SODIUM CHLORIDE;

ADDICTION; BRAIN; BRAIN NERVE CELL; CELL LEVEL; HALF LIFE TIME; HUMAN; LETTER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN METABOLISM;

ANIMALS; BRAIN; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HALF-LIFE; HUMANS; PROTEINS; RECEPTORS, DOPAMINE; SPECIES SPECIFICITY;

EID: 62349088991     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2008.190     Document Type: Letter

References (7)

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2. Brodie BB, Costa E, Blabac A, Neff NH, Smookler HH (1966). Application of steady state kinetics to the estimation of synthesis rate and turnover time of tissue catecholamines. JPET 154: 493-498.
3. Iversen LL, Glowinski J (1966). Regional studies of catecholamines in the rat brain. II. Rate of turnover of catecholamines in various brain regions. J Neurochem 13: 671-682.
4. Kimmel HL, Carroll FI, Kuhar MJ (2003). Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum. JPET 304: 15-21.
5. Kimmel HL, Carroll FI, Kuhar MJ (2001). Dopamine D1 and D2 receptors influence dopamine transporter synthesis and degradation in the rat. JPET 298: 129-140.
6. Kuhar MJ, Joyce AR (2001). Slow onset of CNS drugs: can changes in protein concentration account for the delay? Trends Pharmacol Sci 22: 450-456.
7. Volkow ND, Fowler JS, Wang GJ, Hitzemann R, Logan J, Schlyer DJ et al (1993). Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. Synapse 14: 169-177.