Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum

Journal of Pharmacology and Experimental Therapeutics

Volumn 304, Issue 1, 2003, Pages 15-21

  Kimmel, Heather L ^a   Carroll, F Ivy ^b   Kuhar, Michael J ^a  

^a EMORY UNIVERSITY   (United States)

^b RTI INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (BENZHYDRYLOXY)ETHYL] 4 (3 PHENYLPROPYL)PIPERAZINE; COCAINE; DOPAMINE 1 RECEPTOR BLOCKING AGENT; DOPAMINE 1 RECEPTOR STIMULATING AGENT; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR STIMULATING AGENT; DOPAMINE TRANSPORTER; ISOTHIOCYANIC ACID DERIVATIVE; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; COCAINE DEPENDENCE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG WITHDRAWAL; HALF LIFE TIME; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; RAT; RAT STRAIN; REACTION TIME;

ANIMALS; BEHAVIOR, ANIMAL; COCAINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HALF-LIFE; INJECTIONS, INTRAVENTRICULAR; KINETICS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MEMBRANES; MOTOR ACTIVITY; NEOSTRIATUM; NERVE TISSUE PROTEINS; NUCLEUS ACCUMBENS; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANCE WITHDRAWAL SYNDROME; TROPANES;

EID: 0037215585     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.038018     Document Type: Article

References (40)

1. Alexander GE and Crutcher MD (1990) Functional architecture of basal ganglia circuits: Neural substrates of parallel processing. Trends Neurosci 13:266-271.
2. Arroyo M, Baker WA, and Everitt BJ (2000) Cocaine self-administration in rats differentially alters mRNA levels of the monoamine transporters and striatal neuropeptides. Brain Res Mol Brain Res 83:107-120.
3. Baldo BA, Markou A, and Koob GF (1999) Increased sensitivity to the locomotor depressant effect of a dopamine receptor antagonist during cocaine withdrawal in the rat. Psychopharmacology (Berl) 141:135-144.
4. Bergman J, Madras BK, Johnson SE, and Spealman RD (1989) Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys. J Pharmacol Exp Ther 251:150-155.
5. Boulay D, Duterte-Boucher D, Leroux-Nicollet I, Naudon L, and Costenin J (1996) Locomotor sensitization and decrease in [3H]mazindol binding to the dopamine transporter in the nucleus accumbens are delayed after chronic treatments by GBR12782 or cocaine. J Pharmacol Exp Ther 278:330-337.
6. Burchett SA and Bannon MJ (1997) Serotonin, dopamine and norepinephrine transporter mRNAs: Heterogeneity of distribution and response to 'binge' cocaine administration. Brain Res Mol Brain Res 49:95-102.
7. Carroll FI, Gao Y, Abraham P, Lewin AH, Lew R, Patel A, Boja JW, and Kuhar MJ (1992) Probes for the cocaine receptor. Potentially irreversible ligands for the dopamine transporter. J Med Chem 35:1813-1817.
8. Cerruti C, Pilotte NS, Uhl G, and Kuhar MJ (1994) Reduction in dopamine transporter mRNA after cessation of repeated cocaine administration. Brain Res Mol Brain Res 22:132-138.
9. Clarke PB, Jakubovic A, and Fibiger HC (1988) Anatomical analysis of the involvement of mesolimbocortical dopamine in the locomotor stimulant actions of damphetamine and apomorphine. Psychopharmacology (Berl) 96:511-520.
10. Claye LH, Akunne HC, Davis MD, DeMattos S, and Soliman KFA (1995) Behavioral and neurochemical changes in the dopaminergic system after repeated cocaine administration. Mol Neurobiol 11:55-66.
11. Cote L and Crutcher MD (1991) The basal ganglia, in Principles of Neural Science (Kandel ER, Schwartz JH, and Jessel TM eds) pp 647-658, Elsevier, New York.
12. Davidson C, Ellinwood EH, and Lee TH (2000) Altered sensitivity of dopamine autoreceptors in rat accumbens 1 and 7 days after intermittent or continuous cocaine withdrawal. Brain Res Bull 51:89-93.
13. Delfs JM, Schreiber L, and Kelley AE (1990) Microinjection of cocaine into the nucleus accumbens elicits locomotor activation in the rat. J Neurosci 10:303-310.
14. Di Chiara G and Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85:5274-5278.
15. Everitt BJ and Wolf ME (2002) Psychomotor stimulant addiction: A neural systems perspective. J Neurosci 22:3312-3320.
16. Filip M and Siwanowicz J (2001) Implication of the nucleus accumbens shell, but not core, in the acute and sensitizing effects of cocaine in rats. Pol J Pharmacol 53:459-466.
17. Fleckenstein AE, Pogun S, Carroll FI, and Kuhar MJ (1996) Recovery of dopamine transporter binding and function after intrastriatal administration of the irreversible inhibitor RTI-76 [3β-(3p-chlorophenyl)tropan-2 β-carboxylic acid pisothiocyanatophenylethyl ester hydrochloride. J Pharmacol Exp Ther 279:200-206.
18. Jones SR, Lee TH, Wightman RM, and Ellinwood EH (1996) Effects of intermittent and continuous cocaine administration on dopamine release and uptake regulation in the striatum: In vitro voltammetric assessment. Psychopharmacology (Berl) 126:331-338.
19. Kalivas PW and Duffy P (1990) The effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens. Synapse 5:48-58.
20. Kelley AE and Berridge KC (2002) The neuroscience of natural rewards: Relevance to addictive drugs. J Neurosci 22:3306-3311.
21. Kelly PH and Iversen SD (1976) Selective 6OHDA-induced destruction of mesolimbic dopamine neurons: Abolition of psychostimulant-induced locomotor activity in rats. Eur J Pharmacol 40:45-56.
22. Kimmel HL, Carroll FI, and Kuhar MJ (2000) Dopamine transporter synthesis and degradation rate in rat striatum and nucleus accumbens using RTI-76. Neuropharmacology 39:578-585.
23. Kimmel HL, Joyce AR, Carroll FI, and Kuhar MJ (2001) Dopamine D1 and D2 receptors influence dopamine transporter synthesis and degradation in the rat. J Pharmacol Exp Ther 298:129-140.
24. Kuhar MJ and Pilotte NS (1996) Neurochemical changes in cocaine withdrawal. Trends Pharmacol Sci 17:260-264.
25. Kuhar MJ, Ritz MC, and Boja JW (1991) The dopamine hypothesis of the reinforcing properties of cocaine. Trends Neurosci 14:299-302.
26. Letchworth SR, Daunais JB, Hedgecock AA, and Porrino LJ (1997) Effects of chronic cocaine administration on dopamine transporter mRNA and protein in the rat. Brain Res 750:214-222.
27. Maggos CE, Spangler R, Zhou Y, Schlussman SD, Ho A, and Kreek MJ (1997) Quantitation of dopamine transporter mRNA in rat brain: Mapping, effects of "binge" cocaine administration and withdrawal. Synapse 26:55-61.
28. 1-adrenergic receptors in a nonfusing muscle cell line. J Biol Chem 257:875-879.
29. Mogenson GJ and Nielsen M (1984) Neuropharmacological evidence to suggest that the nucleus accumbens and subpallidal region contribute to exploratory locomotion. Behav Neural Biol 42:52-60.
30. Nestler EJ (1994) Molecular neurobiology of drug addiction. Neuropsychopharmacology 11:77-87.
31. Pierce RC and Kalivas PW (1995) Amphetamine produces sensitized increases in locomotion and extracellular dopamine preferentially in the nucleus accumbens shell of rats administered repeated cocaine. J Pharmacol Exp Ther 275:1019-1029.
32. Pilotte NS, Sharpe LG, and Kuhar MJ (1994) Withdrawal of repeated intravenous infusions of cocaine persistently reduces binding to dopamine transporters in the nucleus accumbens of Lewis rats. J Pharmacol Exp Ther 269:963-969.
33. Pilotte NS, Sharpe LG, Rountree SD, and Kuhar MJ (1996) Cocaine withdrawal reduces dopamine transporter binding in the shell of the nucleus accumbens. Synapse 22:87-92.
34. Ritz MC, Lamb RJ, Goldberg SR, and Kuhar MJ (1987) Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science (Wash DC) 237:1219-1223.
35. 1-adrenergic receptors in rat submaxillary glands. Mol Pharmacol 23:282-288.
36. Todtenkopf MS, Carreiras T, Melloni RH, and Stellar JR (2002) The dorsomedial shell of the nucleus accumbens facilitates cocaine-induced locomotor activity during the induction of behavioral sensitization. Behav Brain Res 131:9-16.
37. Wilcox KM, Paul IA, and Woolverton WL (1999) Comparison between dopamine transporter affinity and self-administration potency of local anesthetics in rhesus monkeys. Eur J Pharmacol 367:175-181.
38. Wilson JM, Nobrega JN, Carroll ME, Niznik HB, Shannak K, Lac ST, Pristupa ZB, Dixon LM, and Kish SJ (1994) Heterogeneous subregional binding patterns of 3H-WIN 35,428 and 3H-GBR 12,935 are differentially regulated by chronic cocaine self-administration. J Neurosci 14:2966-2979.
39. Wise RA, Newton P, Leeb K, Burnette B, Pocock D, and Justice JB Jr (1996) Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats. Psychopharmacology 120:10-20.
40. Xia Y, Goebel DJ, Kapatos G, and Bannon MJ (1992) Quantitation of rat dopamine transporter mRNA: Effects of cocaine treatment and withdrawal. J Neurochem 59:1179-1182.