CTLA4 and generalized vitiligo: Two genetic association studies and a meta-analysis of published data

Pigment Cell and Melanoma Research

Volumn 22, Issue 2, 2009, Pages 230-234

  Birlea, Stanca A ^a,b   Laberge, Greggory S ^a   Procopciuc, Lucia M ^c   Fain, Pamela R ^a,d,e   Spritz, Richard A ^a,e  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^d UNIVERSITY OF COLORADO DENVER   (United States)

^e Children's Hospital Colorado   (United States)

Author keywords

CTLA4; Genetic association; Meta analysis; SNP; Vitiligo

Indexed keywords

ALLELE; ARTICLE; AUTOIMMUNE DISEASE; CAUCASIAN; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 GENE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; VITILIGO;

ALLELES; ANTIGENS, CD; CASE-CONTROL STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MODELS, STATISTICAL; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; ROMANIA; VITILIGO;

EID: 62249219782     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1755-148X.2009.00543.x     Document Type: Article

References (24)

1. Alkhateeb, A., Fain, P.R., Thody, A., Bennett, D.C. Spritz, R.A. (2003). Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families. Pigment Cell Res. 16, 208 214.
2. Barrett, J.C., Fry, B., Maller, J. Daly, M.J. (2005). Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263 265.
3. Blomhoff, A., Kemp, E.H., Gawkrodger, D.J., Weetman, A.P., Husebye, E.S., Akselsen, H.E., Lie, B.A. Undlien, D.E. (2005). CTLA4 polymorphisms are associated with vitiligo, in patients with concomitant autoimmune diseases. Pigment Cell Res. 18, 55 58.
4. Brand, O., Gough, S. Heward, J. (2005). HLA, CTLA-4, and PTPN22: the shared genetic master-key to autoimmunity? Expert Rev Mol Med. 7, 1 15.
5. Dudbridge, F. (2003). Pedigree disequilibrium tests for multilocus haplotypes. Genet. Epidemiol. 25, 115 121.
6. Evangelou, E., Trikalinos, T.A., Salanti, G. Ioannidis, J.P. (2006). Family-based versus unrelated case-control designs for genetic associations. PLoS Genet 2, 1147 1155.
7. Freeman, G.H. Halton, J.H. (1951). Note on exact treatment of contingency goodness of fit and other problems of significance. Biometrika 38, 141 149.
8. Goring, H.H., Terwilliger, J.D. Blangero, J. (2001). Large upward bias in estimation of locus-specific effects from genome-wide scans. Am. J. Hum. Genet. 69, 1357 1369.
9. Gough, S.C., Walker, L.S. Sansom, D.M. (2005). CTLA4 gene polymorphism and autoimmunity. Immunol. Rev. 204, 102 115.
10. Hedges, L.V. Pigott, T.D. (2001). The power of statistical tests in meta-analysis. Psychol. Methods 6, 203 217.
11. Holopainen, P.M. Partanen, J.A. (2001). Technical Note: Linkage disequilibrium and disease-associated CTLA4 gene patterns. J. Immunol. 167, 2457 2458.
12. Itirli, G., Pehlivan, M., Alper, S., Yuksel, S.E., Onay, H., Ozkinay, F. Pehlivan, S. (2005). Exon-3 polymorphism of CTLA-4 gene in Turkish patients with vitiligo. J. Dermatol. Sci. 38, 225 227.
13. Jin, Y., Birlea, S.A., Fain, P.R. Spritz, R.A. (2007). Genetic variations in NALP1 are associated with generalized vitiligo in a Romanian population. J. Invest. Dermatol. 127, 2558 2562.
14. Kavvoura, F.K., Akamizu, T., Awata, T. et al. (2007). Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis. J. Clin. Endocrinol. Metab. 92, 3162 3170.
15. Kemp, E.H., Ajjan, R.A., Waterman, E.A., Gawkrodger, D.J., Cork, M.J., Watson, P.F. Weetman, A.P. (1999). Analysis of a microsatellite polymorphism of the cytotoxic T-lymphocyte antigen-4 gene in patients with vitiligo. Br. J. Dermatol. 140, 73 78.
16. Laberge, G., Mailloux, C.M., Gowan, K., Holland, P., Bennett, D.C., Fain, P.R. Spritz, R.A. (2005). Early disease onset and increased risk of other autoimmune diseases in familial generalized vitiligo. Pigment Cell Res. 18, 300 305.
17. Laberge, G.S., Bennett, D.C., Fain, P.R. Spritz, R.A. (2008). PTPN22 is genetically associated with risk of generalized vitiligo, but CTLA4 is not. J. Invest. Dermatol. 128, 1757 1762.
18. Lau, J., Ioannidis, J.P. Schmid, C.H. (1997). Quantitative synthesis in systematic reviews. Ann. Intern. Med. 127, 820 826.
19. Marchini, J., Howie, B., Myers, S., McVean, G. Donnelly, P. (2007). A new multipoint method for genome-wide association studies by imputation of genotypes. Nat. Genet. 39, 906 913.
20. Nordlund, J.J., Ortonne, J.-P. LePoole, I.C. (2006). Vitiligo vulgaris. In The Pigmentary System, J.J., Nordlund, R.E., Boissy, V.J., Hearing, R.A., King, W.S., Oetting J.-P., Ortonne, eds. 2nd edn Malden, MA : Blackwell Publishing pp. 551 598.
21. Spritz, R.A. (2007). The genetics of generalized vitiligo and associated autoimmune diseases. Pigment Cell Res. 20, 271 278.
22. Spritz, R.A. (2008). The genetics of generalized vitiligo. Curr. Dir. Autoimmun. 10, 244 257.
23. Vaidya, B., Imrie, H., Geatch, D.R. et al. (2000). Association analysis of the cytotoxic T lymphocyte antigen-4 (CTLA-4) and autoimmune regulator-1 (AIRE1) genes in sporadic autoimmune Addison's disease. J. Clin. Endocrinol. Metab. 85, 688 691.
24. Zintzaras, E. (2006). Methylenetetrahydrofolate reductase gene and susceptibility to breast cancer: a meta-analysis. Clin. Genet. 50, 327 333.