Dietary Management of Obesity and Insulin Resistance: Countering Risk for Laminitis

Veterinary Clinics of North America - Equine Practice

Volumn 25, Issue 1, 2009, Pages 51-65

  Geor, Raymond J ^a   Harris, Patricia ^b  

^a Center for Comparative Medicine and Translational Research   (United States)

^b WALTHAM CENTRE FOR PET NUTRITION   (United Kingdom)

Author keywords

Equine metabolic syndrome; Exercise; Insulin sensitivity; Laminitis; Nonstructural carbohydrates

Indexed keywords

ANIMAL; ANIMAL DISEASE; FOOT DISEASE; HORSE; HORSE DISEASE; INSULIN RESISTANCE; OBESITY; PHYSIOLOGY; REVIEW;

ANIMALS; FOOT DISEASES; HORSE DISEASES; HORSES; INSULIN RESISTANCE; OBESITY;

ANIMALIA; EQUIDAE;

EID: 62249121066     PISSN: 07490739     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cveq.2009.02.001     Document Type: Review

References (55)

1. Geor R., and Frank N. Metabolic syndrome-from human organ disease to laminar failure in equids. Vet Immunol Immunopathol (2008) doi:10.1016/j.vetimm.2008.11.012
2. Treiber K.H., Kronfeld D.S., Hess T.M., et al. Evaluation of genetic and metabolic predispositions and nutritional risk factors for pasture-associated laminitis in ponies. J Am Vet Med Assoc 228 (2006) 1538-1545
3. Treiber K.H., Kronfeld D.S., and Geor R.J. Insulin resistance in equids-possible role in laminitis. J Nutr 136 (2006) 2094S-2098S
4. Frank N., Elliott S.B., Brandt L.E., et al. Physical characteristics, blood hormone concentrations, and plasma lipid concentrations in obese horses with insulin resistance. J Am Vet Med Assoc 228 (2006) 1383-1390
5. Bailey S.R., Menzies-Gow N.J., Harris P.A., et al. Effect of dietary fructans and dexamethasone administration on the insulin response of ponies predisposed to laminitis. J Am Vet Med Assoc 231 (2007) 1365-1373
6. Bailey S.R., Habsershon-Butcher J.L., Ransom K.J., et al. Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis. Am J Vet Res 69 (2008) 122-129
7. Carter R.A., Treiber K.H., Geor R.J., et al. Prediction of incipient pasture-associated laminitis from hyperinsulinemia, hyperleptinemia, and generalized and localized obesity in a cohort of ponies. Equine Vet J (2009) 41:171-8.
8. Johnson P.J. The equine metabolic syndrome: peripheral Cushing's syndrome. Vet Clin North Am Equine Pract 18 (2002) 271-293
9. Frank N. Endocrinopathic laminitis, obesity-associated laminitis, and pasture-associated laminitis. Proceedings of 54th Annual Convention of the American Association of Equine Practitioners. San Diego, CA, December 2008.
10. Harris PA, Stewart I. Weight control and management. Proceedings of the First British Equine Veterinary Association and WALTHAM Nutrition Symposia. Suffolk (UK): Equine Veterinary Journal Limited; 2005. p. 99-104.
11. Henneke D.R., Potter G.D., Kreider J.L., et al. Relationship between condition score, physical measurements and body fat percentage in mares. Equine Vet J 15 (1983) 371-372
12. Lee S., Bacha F., Gungor N., et al. Waist circumference is an independent predictor of insulin resistance in black and white youths. J Pediatr 148 (2006) 188-194
13. Alberti K.G., Zimmet P., and Shaw J. Metabolic syndrome-a new world-wide definition. A consensus statement from the International Diabetes Federation. Diabet Med 23 (2006) 469-480
14. United States Department of Agriculture. NAHMS Equine '98. Part III. Management and health of horses. Available at:. www.aphis.usda.gov/vs/ceah/cahm Accessed August 5, 2008
15. Wyse C.A., McNie K.A., Tannahil V.J., et al. Prevalence of obesity in riding horses in Scotland. Vet Rec 162 (2008) 590-591
16. Saltiel A.R., and Kahn C.R. Insulin signaling and the regulation of glucose and lipid metabolism. Nature 414 (2001) 799-806
17. Kahn C.R. Insulin resistance, insulin sensitivity, and insulin unresponsiveness: a necessary distinction. Metabolism 27 (1978) 1893-1902
18. Muniyappa R., Lee S., Chen H., et al. Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations and appropriate usage. Am J Physiol Endocrinol Metab 294 (2008) E15-E26
19. Yudkin J.S. Insulin resistance and the metabolic syndrome-or the pitfalls of epidemiology. Diabetologia 50 (2007) 1576-1586
20. Muoio D.M., and Newgard C.B. Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol 9 (2008) 193-205
21. Carter R.A., McCutcheon L.J., Burns T.A., et al. Increased adiposity in horses is associated with decreased insulin sensitivity but unchanged inflammatory cytokine expression in subcutaneous adipose tissue. J Vet Intern Med 22 (2008) 735 [abstract]
22. Vick M.M., Adams A.A., Murphy B.A., et al. Relationships among inflammatory cytokines, obesity, and insulin sensitivity in the horse. J Anim Sci 85 (2007) 1144-1155
23. Schott II H.C. Pituitary pars intermedia dysfunction: challenges of diagnosis and treatment. Proc Am Assoc Equine Pract 52 (2006) 60-73
24. Donaldson M.T., Jorgensen A.J., and Beech J. Evaluation of suspected pars pituitary intermedia dysfunction in horses with laminitis. J Am Vet Med Assoc 224 (2004) 1123-1127
25. McGowan C.M., Frost R., and Pfeiffer D.U. Serum insulin concentrations in horses with equine Cushing's syndrome: response to a cortisol inhibitor and prognostic value. Equine Vet J 36 (2004) 295-298
26. Hoffman R.M., Boston R.C., Stefanovski D., et al. Obesity and diet affect glucose dynamics and insulin sensitivity in Thoroughbred geldings. J Anim Sci 81 (2003) 2333-2342
27. Kahn R., Buse J., Ferrannini E., et al., for the American Diabetes Association and European Association for the Study of Diabetes. The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and European Association for the Study of Diabetes. Diabetes Care 28 (2005) 2289-2304
28. Dugdale AHA, Curtis GC, Knottenbelt DC, et al. Changes in body condition and fat deposition in ponies offered an ad libitum chaff-based diet. In: Proceedings of the 12th Congress of the European Society for Veterinary Clinical Nutrition; 2008. p. 39 [abstract].
29. Coffman J.R., and Colles C.M. Insulin tolerance in laminitic ponies. Can J Comp Med 47 (1983) 347-351
30. Field J.R., and Jeffcott L.B. Equine laminitis-another hypothesis for pathogenesis. Med Hypotheses 30 (1989) 203-210
31. Treiber K.H., Hess T.M., Kronfeld D.S., et al. Insulin resistance and compensation in laminitis-predisposed ponies characterized by the minimal model. Pferdeheilkunde 21 (2007) 91-92
32. Asplin K.E., Sillence M.N., Pollitt C.C., et al. Induction of laminitis by prolonged hyperinsulinaemia in clinically normal ponies. Vet J 174 (2007) 530-535
33. Tiley H.A., Geor R.J., and McCutcheon L.J. Effects of dexamethasone on glucose dynamics and insulin sensitivity in healthy horses. Am J Vet Res 68 (2007) 753-759
34. Tóth F., Frank N., Elliott S.B., et al. Effects of intravenous endotoxin on glucose and insulin dynamics in horses. Am J Vet Res 69 (2008) 82-88
35. Treiber K.H., Carter R.A., Harris P.A., et al. Seasonal changes in energy metabolism of ponies coincides with changes in pasture carbohydrates: implications for laminitis. J Vet Intern Med 22 (2008) 735-736 [abstract]
36. van Eps A.W., and Pollitt C.C. Equine laminitis induced with oligofructose. Equine Vet J 38 (2006) 203-208
37. Milinovich G.J., Trott D.J., Burrell P.C., et al. Changes in equine hindgut bacterial populations during oligofructose-induced laminitis. Environ Microbiol 8 (2006) 885-898
38. Bailey S.R., Marr C.M., and Elliott J. Current research and theories on the pathogenesis of acute laminitis in the horse. Vet J 167 (2004) 129-142
39. Belknap J.K., Giguere S., Pettigrew A., et al. Lamellar pro-inflammatory cytokine expression patterns in laminitis at the developmental stage and at the onset of lameness: innate vs. adaptive immune response. Equine Vet J 39 (2007) 42-47
40. Firshman A.M., and Valberg S.J. Factors affecting clinical assessment of insulin sensitivity in horses. Equine Vet J 39 (2007) 567-575
41. Eiler H., Frank N., Andrews F.M., et al. Physiologic assessment of blood glucose homeostasis via combined glucose and insulin testing in horses. Am J Vet Res 66 (2005) 1598-1604
42. Harris P.A., Bailey S.R., Elliott J., et al. Countermeasures to pasture-associated laminitis in horses. J Nutr 136 (2006) 2114S-2121S
43. Powell D.M., Reedy S.E., Sessions D.R., et al. Effect of short-term exercise training on insulin sensitivity in obese and lean mares. Equine Vet J Suppl 34 (2002) 81-84
44. Buff P.R., Johnson P.J., Wiedmeyer C.E., et al. Modulation of leptin, insulin and growth hormone in obese pony mares under chronic nutritional restriction and supplementation with ractopamine hydrochloride. Vet Ther 7 (2007) 64-72
45. Ince JC, Longland AC, Moore-Colyer M, et al. A pilot study to estimate the intake of grass by ponies with restricted access to pasture. Proceedings of the British Society of Animal Science. York, England, April 2005.
46. Longland AC, Harker I, Harris PA. The loss of water-soluble carbohydrate and soluble protein from nine different hays submerged in water for up to 16 hours. In: Proceedings of the Equine Science Society, in press 2009.
47. Pagan JD, Lawrence TJ, Lawrence LA. Feeding protected sodium bicarbonate attenuates hindgut acidosis in horses fed a high-grain ration. Proceedings of 54th Annual Convention of the American Association of Equine Practitioners. Orlando, FL, December 2007.
48. Anderson R.A. Chromium in the prevention and control of diabetes. Diabetes Metab (Paris) 26 (2000) 22-27
49. Lau F.C., Bagchi M., Sen C.K., et al. Nutrigenomic basis of beneficial effects of chromium(III) on obesity and diabetes. Mol Cell Biochem 317 (2008) 1-10
50. Verveurt I, Obwald B, Coenen M. Effects of chromium supplementation on metabolic profile in insulin resistant ponies. In: Proceedings of the 12th Congress of the European Society for Veterinary Clinical Nutrition; 2008. p. 40 [abstract].
51. Anon. National Research Council nutrient requirements of horses. 6th revised edition (2007), National Academies Press, Washington, DC
52. Barbagallo M., Dominguez A., Galioto A., et al. Role of magnesium in insulin action, diabetes and cardiovascular syndrome X. Mol Aspects Med 24 (2003) 39-52
53. Song Y., He Y., Levitan E.B., et al. Effects of oral magnesium supplementation on glycaemic control in Type 2 diabetes: a meta-analysis of randomized double blind controlled trials. Diabet Med 23 (2006) 1050-1056
54. Durham A.E., Rendle D.I., and Newton J.E. The effect of metformin on measurements of insulin sensitivity and beta cell response in 18 horses and ponies with insulin resistance. Equine Vet J 40 (2008) 493-500
55. Frank N., Elliott S.B., and Boston R.C. Effects of long-term oral administration of levothyroxine sodium on glucose dynamics in healthy adult horses. Am J Vet Res 69 (2008) 76-81