Prevention of selenite-induced cataractogenesis by N-acetylcysteine in rats

Current Eye Research

Volumn 34, Issue 3, 2009, Pages 196-201

  Aydin, Bahri ^a,c   Yagci, Ramazan ^a   Yilmaz, Fatma M ^b   Erdurmus, Mesut ^a   Karadaǧ, Remzi ^a   Keskin, Ugurcan ^a   Durmus, Mustafa ^a   Yigitoglu, Ramazan ^a  

^a FATIH UNIVERSITY MEDICAL SCHOOL   (Turkey)

^b Ankara Oncology Research and Training Hospital   (Turkey)

^c NONE   (Turkey)

Author keywords

Acetylcysteine; Cataract; Oxidative stress; Rat; Selenite

Indexed keywords

ACETYLCYSTEINE; CARBONYL DERIVATIVE; GLUTATHIONE; MALONALDEHYDE; SELENITE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CATARACTOGENESIS; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFICACY; MICROSCOPY; NONHUMAN; OXIDATIVE STRESS; PERINATAL PERIOD; PRIORITY JOURNAL; PUERPERIUM; RAT; SPRAGUE DAWLEY RAT;

ACETYLCYSTEINE; ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; CATARACT; DISEASE MODELS, ANIMAL; FREE RADICAL SCAVENGERS; GLUTATHIONE; LENS, CRYSTALLINE; MALONDIALDEHYDE; PROTEIN CARBONYLATION; RATS; RATS, SPRAGUE-DAWLEY; SODIUM SELENITE;

EID: 62249113486     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.1080/02713680802676885     Document Type: Article

References (27)

1. West S. Epidemiology of cataract: Accomplishments over 25 years and future directions. Ophthalmic Epidemiol. 2007;14:173-178.
2. Nirmalan PK, Krishnadas R, Ramakrishnan R, Thulasiraj RD, Katz J, Tielsch JM, Robin AL. Lens opacities in a rural population of southern India: The Aravind Comprehensive Eye Study. Invest Ophthalmol Vis Sci. 2003;44:4639-4643.
3. Ughade SN, Zodpey SP, Khanolkar VA. Risk factors for cataract: A case control study. Indian J Ophthalmol. 1998;46:221-227.
4. Shearer TR, Ma H, Fukiage C, Azuma M. Selenite nuclear cataract: Review of the model. Mol Vis. 1997;3:8.
5. Mathew JP, Joseph P, Thomas VC, Thomas I. Glutathione and associated enzymes in toxic cataractogenesis-selenite model. J Environ Biol. 2006;27:733-738.
6. David LL, Shearer TR. State of sulphydryl in selenite cataract. Toxicol Appl Pharmacol. 1984;74:109-115.
7. Vries ND, De Flora S. N-acetyl-l-cysteine. J Cell Biochem. (Suppl) 1993;17:270-277.
8. Holdiness MR. Clinical pharmacokinetics of N-acetylcysteine. Clin Pharmacokinet. 1991;20:123-134.
9. Aruoma OH, Halliwell B, Hoey BM. The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Rad Biol Med. 1989;6:593-597.
10. Cuzzocrea S, Mazzon E, Costantino G, Serraino I, De Sarro A, Caputi AP. Effects of N-acetylcysteine in a rat model of ischemia and reperfusion injury. Cardiovasc Res. 2000;47:537-548.
11. Cohn VH, Lyle J. A fluorometric assay for glutathione. Anal Biochem. 1966;14:434-440.
12. Wasowicz W, Neve J, Peretz A. Optimized steps in fluorometric determination of thiobarbituric acid-reactive substances in serum: Importance of extraction pH and influence of sample preservation and storage. Clin Chem. 1993;39:2522-2526.
13. Reznick AZ, Packer L.Oxidative damage to proteins: Spectrophotometric method for carbonyl assay. Methods Enzymol. 1994;233:357-363.
14. Sies H. Strategies of antioxidant defense. Eur J Biochem. 1993;215:213-219.
15. Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev. 1979;59:527-605.
16. Deneke SM, Fanburg BL. Regulation of cellular glutathione. Lung Cell Mol Physiol. 1989;1:LI63-LI73.
17. Hagen TM, Wierzbicka GT, Sillau AH, Bowman BB, Jones DP. Bioavailability of dietary glutathione: Effect on plasma concentration. Am J Physiol. 1990;259:524-529.
18. Shearer TR, Throneburg DB, Shih M. In vitro precipitation of rat lens crystallins by calpain I - A calpain requiring low amounts of calcium for activation. Ophthalmic Res. 1996;28(Suppl 2):109-114.
19. Shearer TR, Ma H, Shih M, Fukiage C, Azuma M. Calpains in the lens and cataractogenesis. Methods Mol Biol. 2000;144:277-285.
20. Nagasaki H, Nakano H, Boudjema K, Jaeck D, Alexandre E, Baek Y, Kitamura N, Yamaguchi M, Kumada K. Efficacy of preconditioning with N-acetylcysteine against reperfusion injury after prolonged cold ischemia in rats liver in which glutathione had been reduced by buthionine sulphoximine. Eur J Surg. 1998;164:139-146.
21. Shattuck KE, Rassin DK, Grinnell CD. N-acetylcysteine protects from glutathione depletion in rats exposed to hyperoxia. J Parenter Enteral Nutr. 1998;22:228-233.
22. Moschou M, Kosmidis EK, Kaloyianni M, Geronikaki A, Dabarakis N, Theophilidis G. In vitro assessment of the neurotoxic and neuroprotective effects of N-acetyl-L-cysteine (NAC) on the rat sciatic nerve fibers. Toxicol In Vitro. 2008;22:267-274.
23. Knight KR, MacPhadyen K, Lepore DA, Kuwata N, Eadie PA, O'Brien BM. Enhancement of ischemic rabbit skin flap survival with the antioxidant and free radical scavenger N-acetylcysteine. Clin Sci. 1991;81:31-36.
24. Elanchezhian R, Ramesh E, Sakthivel M, Isai M, Geraldine P, Rajamohan M, Jesudasan CN, Thomas PA. Acetyl-L-carnitine prevents selenite-induced cataractogenesis in an experimental animal model. Curr Eye Res. 2007;32:961-971.
25. Biju PG, Rooban BN, Lija Y, Devi VG, Sahasranamam V, Abraham A. Drevogenin D prevents selenite-induced oxidative stress and calpain activation in cultured rat lens. Mol Vis. 2007;13:1121-1129.
26. Yaǧci R, Aydin B, Erdurmu̧ M, Karadaǧ R, Gürel A, Durmuş M, Yiǧitoǧlu R. Use of melatonin to prevent selenite-induced cataract formation in rat eyes. Curr Eye Res. 2006;31:845-850.
27. Varma SD, Hegde KR. Effect of alpha-ketoglutarate against selenite cataract formation. Exp Eye Res. 2004;79:913-918.